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• W2092509986 abstract "Small heat shock proteins form large cytosolic assemblies from an α-crystallin domain (ACD) flanked by sequence extensions. Mutation of a conserved arginine in the ACD of several human small heat shock protein family members causes many common inherited diseases of the lens and neuromuscular system. The mutation R120G in αB-crystallin causes myopathy, cardiomyopathy and cataract. We have solved the X-ray structure of the excised ACD dimer of human αB R120G close to physiological pH and compared it with several recently determined wild-type vertebrate ACD dimer structures. Wild-type excised ACD dimers have a deep groove at the interface floored by a flat extended bottom sheet. Solid-state NMR studies of large assemblies of full-length αB-crystallin have shown that the groove is blocked in the ACD dimer by curvature of the bottom sheet. The crystal structure of R120G ACD dimer also reveals a closed groove, but here the bottom sheet is flat. Loss of Arg120 results in rearrangement of an extensive array of charged interactions across this interface. His83 and Asp80 on movable arches on either side of the interface close the groove by forming two new salt bridges. The residues involved in this extended set of ionic interactions are conserved in Hsp27, Hsp20, αA- and αB-crystallin sequences. They are not conserved in Hsp22, where mutation of the equivalent of Arg120 causes neuropathy. We speculate that the αB R120G mutation disturbs oligomer dynamics, causing the growth of large soluble oligomers that are toxic to cells by blocking essential processes." @default.
• W2092509986 created "2016-06-24" @default.
• W2092509986 creator A5017425103 @default.
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• W2092509986 creator A5077355168 @default.
• W2092509986 creator A5083098838 @default.
• W2092509986 date "2011-04-01" @default.
• W2092509986 modified "2023-09-29" @default.
• W2092509986 title "Crystal Structure of R120G Disease Mutant of Human αB-Crystallin Domain Dimer Shows Closure of a Groove" @default.
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• W2092509986 cites W1790977108 @default.
• W2092509986 cites W1797775581 @default.
• W2092509986 cites W1815807971 @default.
• W2092509986 cites W1964298460 @default.
• W2092509986 cites W1977496718 @default.
• W2092509986 cites W1979775299 @default.
• W2092509986 cites W1983790438 @default.
• W2092509986 cites W1988146888 @default.
• W2092509986 cites W1989252221 @default.
• W2092509986 cites W2001111895 @default.
• W2092509986 cites W2001641653 @default.
• W2092509986 cites W2001970265 @default.
• W2092509986 cites W2002602401 @default.
• W2092509986 cites W2004688346 @default.
• W2092509986 cites W2007780468 @default.
• W2092509986 cites W2010188733 @default.
• W2092509986 cites W2010855976 @default.
• W2092509986 cites W2012490977 @default.
• W2092509986 cites W2013288236 @default.
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• W2092509986 cites W2018084854 @default.
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• W2092509986 cites W2025493128 @default.
• W2092509986 cites W2025994242 @default.
• W2092509986 cites W2035503835 @default.
• W2092509986 cites W2038840577 @default.
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• W2092509986 cites W2076159058 @default.
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• W2092509986 doi "https://doi.org/10.1016/j.jmb.2011.02.020" @default.
• W2092509986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3158665" @default.
• W2092509986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21329698" @default.
• W2092509986 hasPublicationYear "2011" @default.
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