FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092533097> ?p ?o ?g. }

• W2092533097 endingPage "232" @default.
• W2092533097 startingPage "223" @default.
• W2092533097 abstract "Abstract Glucagon‐like peptide‐1 (7‐36) amide (GLP‐1) is a gut hormone, released postprandially, which stimulates insulin secretion and insulin gene expression as well as pancreatic B‐cell growth. Together with glucose‐dependent insulinotropic polypeptide (GIP), it is responsible for the incretin effect which is the augmentation of insulin secretion following oral administration of glucose. Patients with Type 2 diabetes have greatly impaired or absent incretin‐mediated insulin secretion which is mainly as a result of decreased secretion of GLP‐1. However, the insulinotropic action of GLP‐1 is preserved in patients with Type 2 diabetes, and this has encouraged attempts to treat Type 2 diabetic patients with GLP‐1. GLP‐1 also possesses a number of potential advantages over existing agents for the treatment of Type 2 diabetes. In addition to stimulating insulin secretion and promoting pancreatic B‐cell mass, GLP‐1 suppresses glucagon secretion, delays gastric emptying and inhibits food intake. Continuous intravenous and subcutaneous administration significantly improves glycaemic control and causes reductions in both HbA 1c and body weight. However, GLP‐1 is metabolized extremely rapidly in the circulation by the enzyme dipeptidyl peptidase IV (DPP‐IV). This is the probable explanation for the short‐lived effect of single doses of native GLP‐1, making it an unlikely glucose‐lowering agent. The DPP‐IV resistant analogue, exenatide, has Food and Drug Administration (FDA) approval for the treatment of Type 2 diabetes and selective DPP‐IV inhibitors are under development. Both approaches have demonstrated remarkable efficacy in animal models and human clinical studies. Both are well tolerated and appear to have advantages over current therapies for Type 2 diabetes, particularly in terms of the effects on pancreatic B‐cell restoration and potential weight loss." @default.
• W2092533097 created "2016-06-24" @default.
• W2092533097 creator A5011196462 @default.
• W2092533097 creator A5071555741 @default.
• W2092533097 date "2007-02-14" @default.
• W2092533097 modified "2023-10-10" @default.
• W2092533097 title "Incretins and other peptides in the treatment of diabetes" @default.
• W2092533097 cites W1909705449 @default.
• W2092533097 cites W1910418518 @default.
• W2092533097 cites W1969628999 @default.
• W2092533097 cites W1969932276 @default.
• W2092533097 cites W1977119153 @default.
• W2092533097 cites W1977274289 @default.
• W2092533097 cites W1977881896 @default.
• W2092533097 cites W1978953702 @default.
• W2092533097 cites W1979916078 @default.
• W2092533097 cites W1982785685 @default.
• W2092533097 cites W1984740259 @default.
• W2092533097 cites W1986085856 @default.
• W2092533097 cites W1991477535 @default.
• W2092533097 cites W1991565451 @default.
• W2092533097 cites W1996430497 @default.
• W2092533097 cites W2000465889 @default.
• W2092533097 cites W2004803648 @default.
• W2092533097 cites W2010208232 @default.
• W2092533097 cites W2010658627 @default.
• W2092533097 cites W2013082477 @default.
• W2092533097 cites W2013851956 @default.
• W2092533097 cites W2014243511 @default.
• W2092533097 cites W2016732441 @default.
• W2092533097 cites W2017201029 @default.
• W2092533097 cites W2019099090 @default.
• W2092533097 cites W2019252344 @default.
• W2092533097 cites W2023068384 @default.
• W2092533097 cites W2023462541 @default.
• W2092533097 cites W2024058025 @default.
• W2092533097 cites W2024409703 @default.
• W2092533097 cites W2025237740 @default.
• W2092533097 cites W2025257352 @default.
• W2092533097 cites W2028272916 @default.
• W2092533097 cites W2028515800 @default.
• W2092533097 cites W2030347165 @default.
• W2092533097 cites W2031468509 @default.
• W2092533097 cites W2036167841 @default.
• W2092533097 cites W2037435528 @default.
• W2092533097 cites W2042529296 @default.
• W2092533097 cites W2054564814 @default.
• W2092533097 cites W2056319298 @default.
• W2092533097 cites W2056934377 @default.
• W2092533097 cites W2060949491 @default.
• W2092533097 cites W2061202826 @default.
• W2092533097 cites W2068488844 @default.
• W2092533097 cites W2073996229 @default.
• W2092533097 cites W2074511950 @default.
• W2092533097 cites W2076880341 @default.
• W2092533097 cites W2077149049 @default.
• W2092533097 cites W2080128749 @default.
• W2092533097 cites W2081666098 @default.
• W2092533097 cites W2087063469 @default.
• W2092533097 cites W2089304685 @default.
• W2092533097 cites W2093303670 @default.
• W2092533097 cites W2096444181 @default.
• W2092533097 cites W2101613382 @default.
• W2092533097 cites W2101718966 @default.
• W2092533097 cites W2102400698 @default.
• W2092533097 cites W2104239190 @default.
• W2092533097 cites W2104763836 @default.
• W2092533097 cites W2106824929 @default.
• W2092533097 cites W2109069837 @default.
• W2092533097 cites W2111865924 @default.
• W2092533097 cites W2113544353 @default.
• W2092533097 cites W2119987208 @default.
• W2092533097 cites W2122946361 @default.
• W2092533097 cites W2125036135 @default.
• W2092533097 cites W2126520659 @default.
• W2092533097 cites W2127409471 @default.
• W2092533097 cites W2128979121 @default.
• W2092533097 cites W2133314206 @default.
• W2092533097 cites W2138299702 @default.
• W2092533097 cites W2140137473 @default.
• W2092533097 cites W2140978079 @default.
• W2092533097 cites W2141338760 @default.
• W2092533097 cites W2143014102 @default.
• W2092533097 cites W2143752451 @default.
• W2092533097 cites W2143847100 @default.
• W2092533097 cites W2145266416 @default.
• W2092533097 cites W2145329719 @default.
• W2092533097 cites W2146232529 @default.
• W2092533097 cites W2146333376 @default.
• W2092533097 cites W2146400000 @default.
• W2092533097 cites W2146581079 @default.
• W2092533097 cites W2150137315 @default.
• W2092533097 cites W2155633307 @default.
• W2092533097 cites W2162934281 @default.
• W2092533097 cites W2172204314 @default.
• W2092533097 cites W2262517533 @default.
• W2092533097 cites W4232352885 @default.
• W2092533097 cites W4232859665 @default.

• next