Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092562017> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2092562017 endingPage "202" @default.
- W2092562017 startingPage "199" @default.
- W2092562017 abstract "In frog brain membranes, equilibrium saturation binding of the opiate agonist : 3H-etorphine and of the opiate antagonist : 3H-diprenorphine is biphasic. In the presence of sodium ions (120 mM), “kinetic conversions” (unchanged Bmax) are observed : high affinity binding of the 3H-agonist is decreased while high affinity binding of the antagonist is increased. Frog brain membranes were labelled either with 3H-etorphine or with 3H-diprenorphine and solubilized with digitonin. The soluble extracts were centrifuged in sucrose gradients: two distinct components were labelled which sedimented respectively faster (∼ 12 S) and slower (∼ 10 S) than did catalase, used as marker. Pre-incubation of membrane and of 3H-ligand in the presence of 120 mM NaCl resulted in 1) considerably reduced recovery of the 12 S component in labelled form and 2) substantially enhanced labelling of the 10 S component with the 3H-antagonist. Gpp(NH)p (guanyl-5′-yl imidodiphosphate) exerted similar effects as did sodium ions. Taken together, these data suggest that the two components in question represent physically distinct agonist and antagonist forms of frog brain opiate receptors." @default.
- W2092562017 created "2016-06-24" @default.
- W2092562017 creator A5003590632 @default.
- W2092562017 creator A5010184048 @default.
- W2092562017 creator A5014254074 @default.
- W2092562017 date "1983-01-01" @default.
- W2092562017 modified "2023-09-25" @default.
- W2092562017 title "Distinct molecular forms of opiate binding in the frog brain" @default.
- W2092562017 cites W1238935559 @default.
- W2092562017 cites W1979569718 @default.
- W2092562017 cites W1996997570 @default.
- W2092562017 cites W2023620032 @default.
- W2092562017 cites W2037437115 @default.
- W2092562017 cites W2058433555 @default.
- W2092562017 cites W2075811628 @default.
- W2092562017 doi "https://doi.org/10.1016/0024-3205(83)90477-0" @default.
- W2092562017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6319860" @default.
- W2092562017 hasPublicationYear "1983" @default.
- W2092562017 type Work @default.
- W2092562017 sameAs 2092562017 @default.
- W2092562017 citedByCount "15" @default.
- W2092562017 crossrefType "journal-article" @default.
- W2092562017 hasAuthorship W2092562017A5003590632 @default.
- W2092562017 hasAuthorship W2092562017A5010184048 @default.
- W2092562017 hasAuthorship W2092562017A5014254074 @default.
- W2092562017 hasConcept C12554922 @default.
- W2092562017 hasConcept C170493617 @default.
- W2092562017 hasConcept C178790620 @default.
- W2092562017 hasConcept C185592680 @default.
- W2092562017 hasConcept C2776885963 @default.
- W2092562017 hasConcept C2778140631 @default.
- W2092562017 hasConcept C2778750930 @default.
- W2092562017 hasConcept C2778920010 @default.
- W2092562017 hasConcept C2778938600 @default.
- W2092562017 hasConcept C2779012664 @default.
- W2092562017 hasConcept C2779166228 @default.
- W2092562017 hasConcept C41625074 @default.
- W2092562017 hasConcept C537181965 @default.
- W2092562017 hasConcept C55493867 @default.
- W2092562017 hasConcept C71240020 @default.
- W2092562017 hasConcept C86803240 @default.
- W2092562017 hasConceptScore W2092562017C12554922 @default.
- W2092562017 hasConceptScore W2092562017C170493617 @default.
- W2092562017 hasConceptScore W2092562017C178790620 @default.
- W2092562017 hasConceptScore W2092562017C185592680 @default.
- W2092562017 hasConceptScore W2092562017C2776885963 @default.
- W2092562017 hasConceptScore W2092562017C2778140631 @default.
- W2092562017 hasConceptScore W2092562017C2778750930 @default.
- W2092562017 hasConceptScore W2092562017C2778920010 @default.
- W2092562017 hasConceptScore W2092562017C2778938600 @default.
- W2092562017 hasConceptScore W2092562017C2779012664 @default.
- W2092562017 hasConceptScore W2092562017C2779166228 @default.
- W2092562017 hasConceptScore W2092562017C41625074 @default.
- W2092562017 hasConceptScore W2092562017C537181965 @default.
- W2092562017 hasConceptScore W2092562017C55493867 @default.
- W2092562017 hasConceptScore W2092562017C71240020 @default.
- W2092562017 hasConceptScore W2092562017C86803240 @default.
- W2092562017 hasLocation W20925620171 @default.
- W2092562017 hasLocation W20925620172 @default.
- W2092562017 hasOpenAccess W2092562017 @default.
- W2092562017 hasPrimaryLocation W20925620171 @default.
- W2092562017 hasRelatedWork W1764777080 @default.
- W2092562017 hasRelatedWork W1977249450 @default.
- W2092562017 hasRelatedWork W2004189259 @default.
- W2092562017 hasRelatedWork W2062071714 @default.
- W2092562017 hasRelatedWork W2084455757 @default.
- W2092562017 hasRelatedWork W2086145765 @default.
- W2092562017 hasRelatedWork W2092562017 @default.
- W2092562017 hasRelatedWork W2093515812 @default.
- W2092562017 hasRelatedWork W2434007227 @default.
- W2092562017 hasRelatedWork W5459083 @default.
- W2092562017 hasVolume "33" @default.
- W2092562017 isParatext "false" @default.
- W2092562017 isRetracted "false" @default.
- W2092562017 magId "2092562017" @default.
- W2092562017 workType "article" @default.