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- W2092595224 abstract "The in vivo and in vitro bindings of radiolabeled rotenoids to mitochondrial complex I of rat striatum were examined after unilateral intrastriatal injections of quinolinic acid or 1-methyl-4-phenylpyridinium salt (MPP + ). Quinolinic acid produced significant, similar losses of in vivo binding of [ 11 C]dihydrorotenol ([ 11 C]DHROL: 40%) and in vitro binding of [ 3 H]dihydrorotenone ([ 3 H]DHR: 53%) in the injected striata at 13 days after the injection of neurotoxin. MPP + reduced in vivo binding of [ 11 C]DHROL (up to −55%) as measured 1.5 to 6 h after its administration. Reductions of in vivo [ 11 C]DHROL binding after either quinolinic acid or MPP + injections did not correlate with changes in striatal blood flow as measured with [ 14 C]iodoantipyrine. These results are consistent with losses of complex I binding sites for radiolabeled rotenoids, produced using cell death (quinolinic acid) or direct competition for the binding site (MPP + ). Appropriately radiolabeled rotenoids may be useful for in vivo imaging studies of changes of complex I in neurodegenerative diseases." @default.
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- W2092595224 date "1997-03-01" @default.
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- W2092595224 title "Intrastriatal Neurotoxin Injections Reduce in Vitro and in Vivo Binding of Radiolabeled Rotenoids to Mitochondrial Complex I" @default.
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- W2092595224 doi "https://doi.org/10.1097/00004647-199703000-00003" @default.
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