FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092597744> ?p ?o ?g. }

• W2092597744 endingPage "1977" @default.
• W2092597744 startingPage "1971" @default.
• W2092597744 abstract "To further define the conditions for forming spectrin-hemoglobin cross-linking in human erythrocyte membranes and to examine its possible effects on membrane function, we incubated normal human erythrocytes for up to 3 h in concentrations of H2O2, varying from 45 to 180 microM, in an azide phosphate buffer, pH 7.4. The chemical changes observed indicated that methemoglobin formation occurred early and at a low concentration (45 microM). Morphologic changes characterized by increased echinocyte formation occurred in a dose-dependent fashion. In addition, decreased cell deformability commensurate with increased membrane rigidity was found. Finally, an increase in cell recognition as determined by monocyte phagocytosis and adherence in vitro, as well as decreased phosphatidylcholine accessibility to bee venom phospholipase A2, was found in H2O2-treated erythrocytes compared with controls. Both of these latter changes were closely correlated with the extent of spectrin-hemoglobin cross-linking. In addition to these protein-mediated interactions, lipid peroxidation also occurred after H2O2 exposure, as shown by generation of fluorescent amino propene derivatives. The addition of the antioxidant, butylated hydroxytoluene, decreased the fluorescent derivatives, but did not prevent the effects on membrane function. This suggests that lipid peroxidation, though present, was not necessary for the membrane changes found. In contrast, spectrin-hemoglobin aggregation and the alterations in membrane function were completely prevented by prior exposure of the erythrocytes to carbon monoxide." @default.
• W2092597744 created "2016-06-24" @default.
• W2092597744 creator A5013609861 @default.
• W2092597744 creator A5034746599 @default.
• W2092597744 creator A5035797201 @default.
• W2092597744 creator A5037269928 @default.
• W2092597744 creator A5046553788 @default.
• W2092597744 creator A5066499404 @default.
• W2092597744 creator A5067233184 @default.
• W2092597744 creator A5074910052 @default.
• W2092597744 creator A5076373401 @default.
• W2092597744 date "1985-11-01" @default.
• W2092597744 modified "2023-10-15" @default.
• W2092597744 title "Effect of hydrogen peroxide exposure on normal human erythrocyte deformability, morphology, surface characteristics, and spectrin-hemoglobin cross-linking." @default.
• W2092597744 cites W141631069 @default.
• W2092597744 cites W1545685256 @default.
• W2092597744 cites W1591926754 @default.
• W2092597744 cites W1604900522 @default.
• W2092597744 cites W1970714466 @default.
• W2092597744 cites W1980707629 @default.
• W2092597744 cites W1986645079 @default.
• W2092597744 cites W1987410604 @default.
• W2092597744 cites W2005859080 @default.
• W2092597744 cites W2010867586 @default.
• W2092597744 cites W2015707217 @default.
• W2092597744 cites W2037383733 @default.
• W2092597744 cites W2039712539 @default.
• W2092597744 cites W2048859044 @default.
• W2092597744 cites W2060741711 @default.
• W2092597744 cites W2068653380 @default.
• W2092597744 cites W2084011431 @default.
• W2092597744 cites W2091647374 @default.
• W2092597744 cites W2104094996 @default.
• W2092597744 cites W2138893502 @default.
• W2092597744 cites W2145504663 @default.
• W2092597744 cites W2186595494 @default.
• W2092597744 cites W2412117772 @default.
• W2092597744 cites W2412174089 @default.
• W2092597744 cites W2423439034 @default.
• W2092597744 cites W2466454510 @default.
• W2092597744 doi "https://doi.org/10.1172/jci112196" @default.
• W2092597744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/424255" @default.
• W2092597744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4056060" @default.
• W2092597744 hasPublicationYear "1985" @default.
• W2092597744 type Work @default.
• W2092597744 sameAs 2092597744 @default.
• W2092597744 citedByCount "256" @default.
• W2092597744 countsByYear W20925977442012 @default.
• W2092597744 countsByYear W20925977442013 @default.
• W2092597744 countsByYear W20925977442014 @default.
• W2092597744 countsByYear W20925977442015 @default.
• W2092597744 countsByYear W20925977442016 @default.
• W2092597744 countsByYear W20925977442017 @default.
• W2092597744 countsByYear W20925977442018 @default.
• W2092597744 countsByYear W20925977442019 @default.
• W2092597744 countsByYear W20925977442020 @default.
• W2092597744 countsByYear W20925977442021 @default.
• W2092597744 countsByYear W20925977442022 @default.
• W2092597744 countsByYear W20925977442023 @default.
• W2092597744 crossrefType "journal-article" @default.
• W2092597744 hasAuthorship W2092597744A5013609861 @default.
• W2092597744 hasAuthorship W2092597744A5034746599 @default.
• W2092597744 hasAuthorship W2092597744A5035797201 @default.
• W2092597744 hasAuthorship W2092597744A5037269928 @default.
• W2092597744 hasAuthorship W2092597744A5046553788 @default.
• W2092597744 hasAuthorship W2092597744A5066499404 @default.
• W2092597744 hasAuthorship W2092597744A5067233184 @default.
• W2092597744 hasAuthorship W2092597744A5074910052 @default.
• W2092597744 hasAuthorship W2092597744A5076373401 @default.
• W2092597744 hasBestOaLocation W20925977441 @default.
• W2092597744 hasConcept C107565407 @default.
• W2092597744 hasConcept C12554922 @default.
• W2092597744 hasConcept C142669718 @default.
• W2092597744 hasConcept C1448646 @default.
• W2092597744 hasConcept C1491633281 @default.
• W2092597744 hasConcept C151666851 @default.
• W2092597744 hasConcept C185592680 @default.
• W2092597744 hasConcept C26865036 @default.
• W2092597744 hasConcept C2776185378 @default.
• W2092597744 hasConcept C2776557347 @default.
• W2092597744 hasConcept C2778004101 @default.
• W2092597744 hasConcept C2778917026 @default.
• W2092597744 hasConcept C2780829032 @default.
• W2092597744 hasConcept C41625074 @default.
• W2092597744 hasConcept C50244902 @default.
• W2092597744 hasConcept C55493867 @default.
• W2092597744 hasConcept C86803240 @default.
• W2092597744 hasConceptScore W2092597744C107565407 @default.
• W2092597744 hasConceptScore W2092597744C12554922 @default.
• W2092597744 hasConceptScore W2092597744C142669718 @default.
• W2092597744 hasConceptScore W2092597744C1448646 @default.
• W2092597744 hasConceptScore W2092597744C1491633281 @default.
• W2092597744 hasConceptScore W2092597744C151666851 @default.
• W2092597744 hasConceptScore W2092597744C185592680 @default.
• W2092597744 hasConceptScore W2092597744C26865036 @default.
• W2092597744 hasConceptScore W2092597744C2776185378 @default.
• W2092597744 hasConceptScore W2092597744C2776557347 @default.
• W2092597744 hasConceptScore W2092597744C2778004101 @default.

• next