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- W2092603988 abstract "The frequencies at which four VH gene families pair with the λ1 light (L) chain were determined by sequential hybridization of VH- and λ1-specific DNA probes to mitogen-induced colonies of B cells. Analysis of pair frequencies indicates that the repertoire of λ L chain antibodies is generated by the stochastic pairing of smaller 3′-to-mid-locusVH gene families (X-24, S107, Q52). However, the large 5′ VH J558 family appeared to associate with the λ1L chain non-stochastically; the frequency of VhJ558/λ1+ colonies among all λ1+ colonies was significantly lower than the frequency of J558 expression among all (Cμ+) B cell colonies. This difference suggests that selection, either intrinsic at the level of rearrangement or heavy and L chain pairing, or extrinsic following surface immunoglobulin expression, may operate to shape the λ antibody repertoire prior to the introduction of exogenous antigen." @default.
- W2092603988 created "2016-06-24" @default.
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- W2092603988 date "1993-08-01" @default.
- W2092603988 modified "2023-09-23" @default.
- W2092603988 title "Pairing of VH gene families with the λ light chain: Evidence for a non-stochastic association" @default.
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- W2092603988 doi "https://doi.org/10.1002/eji.1830230837" @default.
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