FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092604966> ?p ?o ?g. }

• W2092604966 endingPage "e13251" @default.
• W2092604966 startingPage "e13251" @default.
• W2092604966 abstract "Chronic obstructive pulmonary disease is a progressive lung disease that is punctuated by periods of exacerbations (worsening of symptoms) that are attributable to viral infections. While rhinoviruses are most commonly isolated viruses during episodes of exacerbation, influenza viruses have the potential to become even more problematic with the increased likelihood of an epidemic.This study examined the impact of current and potential pharmacological targets namely the systemic corticosteroid dexamethasone and the peroxisome proliferator-activated receptor-gamma agonist pioglitazone on the outcome of infection in smoke-exposed mice. C57BL/6 mice were exposed to room air or cigarette smoke for 4 days and subsequently inoculated with an H1N1 influenza A virus. Interventions were delivered daily during the course of infection. We show that smoke-exposed mice have an exacerbated inflammatory response following infection. While smoke exposure did not compromise viral clearance, precision cut lung slices from smoke-exposed mice showed greater expression of CC (MCP-1, -3), and CXC (KC, MIP-2, GCP-2) chemokines compared to controls when stimulated with a viral mimic or influenza A virus. While dexamethasone treatment partially attenuated the inflammatory response in the broncho-alveolar lavage of smoke-exposed, virally-infected animals, viral-induced neutrophilia was steroid insensitive. In contrast to controls, dexamethasone-treated smoke-exposed influenza-infected mice had a worsened health status. Pioglitazone treatment of virally-infected smoke-exposed mice proved more efficacious than the steroid intervention. Further mechanistic evaluation revealed that a deficiency in CCR2 did not improve the inflammatory outcome in smoke-exposed, virally-infected animals.This animal model of cigarette smoke and H1N1 influenza infection demonstrates that smoke-exposed animals are differentially primed to respond to viral insult. While providing a platform to test pharmacological interventions, this model demonstrates that treating viral exacerbations with alternative anti-inflammatory drugs, such as PPAR-gamma agonists should be further explored since they showed greater efficacy than systemic corticosteroids." @default.
• W2092604966 created "2016-06-24" @default.
• W2092604966 creator A5028737873 @default.
• W2092604966 creator A5033376487 @default.
• W2092604966 creator A5040791918 @default.
• W2092604966 creator A5045234215 @default.
• W2092604966 creator A5066081846 @default.
• W2092604966 creator A5071381385 @default.
• W2092604966 creator A5078849862 @default.
• W2092604966 creator A5090915376 @default.
• W2092604966 date "2010-10-12" @default.
• W2092604966 modified "2023-09-23" @default.
• W2092604966 title "Treating Viral Exacerbations of Chronic Obstructive Pulmonary Disease: Insights from a Mouse Model of Cigarette Smoke and H1N1 Influenza Infection" @default.
• W2092604966 cites W1603103547 @default.
• W2092604966 cites W1889521160 @default.
• W2092604966 cites W1974278677 @default.
• W2092604966 cites W1977142289 @default.
• W2092604966 cites W1977768637 @default.
• W2092604966 cites W2010967671 @default.
• W2092604966 cites W2017505271 @default.
• W2092604966 cites W2023012924 @default.
• W2092604966 cites W2029129294 @default.
• W2092604966 cites W2048351247 @default.
• W2092604966 cites W2050192510 @default.
• W2092604966 cites W2053798956 @default.
• W2092604966 cites W2058975819 @default.
• W2092604966 cites W2060075310 @default.
• W2092604966 cites W2079885775 @default.
• W2092604966 cites W2098626488 @default.
• W2092604966 cites W2106601190 @default.
• W2092604966 cites W2107560422 @default.
• W2092604966 cites W2108600759 @default.
• W2092604966 cites W2110947112 @default.
• W2092604966 cites W2111190622 @default.
• W2092604966 cites W2118269576 @default.
• W2092604966 cites W2122728955 @default.
• W2092604966 cites W2137564770 @default.
• W2092604966 cites W2141702779 @default.
• W2092604966 cites W2144048943 @default.
• W2092604966 cites W2145710202 @default.
• W2092604966 cites W2150573491 @default.
• W2092604966 cites W2159470225 @default.
• W2092604966 cites W2162938574 @default.
• W2092604966 cites W2163267243 @default.
• W2092604966 cites W2164423440 @default.
• W2092604966 cites W2164473561 @default.
• W2092604966 cites W2166432084 @default.
• W2092604966 cites W2168078376 @default.
• W2092604966 doi "https://doi.org/10.1371/journal.pone.0013251" @default.
• W2092604966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2953496" @default.
• W2092604966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20967263" @default.
• W2092604966 hasPublicationYear "2010" @default.
• W2092604966 type Work @default.
• W2092604966 sameAs 2092604966 @default.
• W2092604966 citedByCount "86" @default.
• W2092604966 countsByYear W20926049662012 @default.
• W2092604966 countsByYear W20926049662013 @default.
• W2092604966 countsByYear W20926049662014 @default.
• W2092604966 countsByYear W20926049662015 @default.
• W2092604966 countsByYear W20926049662016 @default.
• W2092604966 countsByYear W20926049662017 @default.
• W2092604966 countsByYear W20926049662018 @default.
• W2092604966 countsByYear W20926049662019 @default.
• W2092604966 countsByYear W20926049662020 @default.
• W2092604966 countsByYear W20926049662021 @default.
• W2092604966 countsByYear W20926049662022 @default.
• W2092604966 countsByYear W20926049662023 @default.
• W2092604966 crossrefType "journal-article" @default.
• W2092604966 hasAuthorship W2092604966A5028737873 @default.
• W2092604966 hasAuthorship W2092604966A5033376487 @default.
• W2092604966 hasAuthorship W2092604966A5040791918 @default.
• W2092604966 hasAuthorship W2092604966A5045234215 @default.
• W2092604966 hasAuthorship W2092604966A5066081846 @default.
• W2092604966 hasAuthorship W2092604966A5071381385 @default.
• W2092604966 hasAuthorship W2092604966A5078849862 @default.
• W2092604966 hasAuthorship W2092604966A5090915376 @default.
• W2092604966 hasBestOaLocation W20926049661 @default.
• W2092604966 hasConcept C126322002 @default.
• W2092604966 hasConcept C203014093 @default.
• W2092604966 hasConcept C2522874641 @default.
• W2092604966 hasConcept C2777546802 @default.
• W2092604966 hasConcept C2777714996 @default.
• W2092604966 hasConcept C2777802486 @default.
• W2092604966 hasConcept C2780401358 @default.
• W2092604966 hasConcept C71924100 @default.
• W2092604966 hasConceptScore W2092604966C126322002 @default.
• W2092604966 hasConceptScore W2092604966C203014093 @default.
• W2092604966 hasConceptScore W2092604966C2522874641 @default.
• W2092604966 hasConceptScore W2092604966C2777546802 @default.
• W2092604966 hasConceptScore W2092604966C2777714996 @default.
• W2092604966 hasConceptScore W2092604966C2777802486 @default.
• W2092604966 hasConceptScore W2092604966C2780401358 @default.
• W2092604966 hasConceptScore W2092604966C71924100 @default.
• W2092604966 hasIssue "10" @default.
• W2092604966 hasLocation W20926049661 @default.
• W2092604966 hasLocation W20926049662 @default.
• W2092604966 hasLocation W20926049663 @default.
• W2092604966 hasLocation W20926049664 @default.

• next