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- W2092607595 endingPage "5266" @default.
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- W2092607595 abstract "Synthetically useful N-Fmoc amino-alkyl isothiocyanates have been described, starting from protected amino acids. These compounds have been synthesized in excellent yields by thiocarbonylation of the monoprotected 1,2-diamines with CS2/TEA/p-TsCl, isolated as stable solids, and completely characterized. The procedure has been extended to the synthesis of amino alkyl isothiocyanates from Boc- and Z-protected amino acids as well. The utility of these isothiocyanates for peptidomimetics synthesis has been demonstrated by employing them in the preparation of a series of dithioureidopeptide esters. Boc-Gly-OH and Boc-Phe-OH derived isothiocyanates 9a and 9c have been obtained as single crystals and their structures solved through X-ray diffraction. They belong to the orthorhombic crystal system, and have a single molecule in the asymmetric unit (Z' = 1). 9a crystallizes in the centrosymmetric space group Pbca, while 9c crystallizes in the noncentrosymmetric space group P2(1)2(1)2(1)." @default.
- W2092607595 created "2016-06-24" @default.
- W2092607595 creator A5000277470 @default.
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- W2092607595 creator A5047667045 @default.
- W2092607595 creator A5082335200 @default.
- W2092607595 creator A5082537967 @default.
- W2092607595 date "2009-06-18" @default.
- W2092607595 modified "2023-09-24" @default.
- W2092607595 title "N-Urethane-Protected Amino Alkyl Isothiocyanates: Synthesis, Isolation, Characterization, and Application to the Synthesis of Thioureidopeptides" @default.
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