FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092608998> ?p ?o ?g. }

• W2092608998 endingPage "390" @default.
• W2092608998 startingPage "379" @default.
• W2092608998 abstract "Lipid accumulation in hepatocytes can lead to non-alcoholic fatty liver disease (NAFLD), which can progress to non-alcoholic steatohepatitis (NASH) and Type 2 diabetes (T2D). Hormone-initiated release of Ca2+ from the endoplasmic reticulum (ER) stores and subsequent replenishment of these stores by Ca2+ entry through SOCs (store-operated Ca2+ channels; SOCE) plays a critical role in the regulation of liver metabolism. ER Ca2+ homoeostasis is known to be altered in steatotic hepatocytes. Whether store-operated Ca2+ entry is altered in steatotic hepatocytes and the mechanisms involved were investigated. Lipid accumulation in vitro was induced in cultured liver cells by amiodarone or palmitate and in vivo in hepatocytes isolated from obese Zucker rats. Rates of Ca2+ entry and release were substantially reduced in lipid-loaded cells. Inhibition of Ca2+ entry was associated with reduced hormone-initiated intracellular Ca2+ signalling and enhanced lipid accumulation. Impaired Ca2+ entry was not associated with altered expression of stromal interaction molecule 1 (STIM1) or Orai1. Inhibition of protein kinase C (PKC) reversed the impairment of Ca2+ entry in lipid-loaded cells. It is concluded that steatosis leads to a substantial inhibition of SOCE through a PKC-dependent mechanism. This enhances lipid accumulation by positive feedback and may contribute to the development of NASH and insulin resistance." @default.
• W2092608998 created "2016-06-24" @default.
• W2092608998 creator A5009737472 @default.
• W2092608998 creator A5024794283 @default.
• W2092608998 creator A5037220260 @default.
• W2092608998 creator A5043923263 @default.
• W2092608998 creator A5055432522 @default.
• W2092608998 creator A5061342475 @default.
• W2092608998 creator A5085818807 @default.
• W2092608998 creator A5087544909 @default.
• W2092608998 date "2015-02-20" @default.
• W2092608998 modified "2023-10-18" @default.
• W2092608998 title "Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C-dependent mechanism" @default.
• W2092608998 cites W1594572310 @default.
• W2092608998 cites W1755902553 @default.
• W2092608998 cites W1963786607 @default.
• W2092608998 cites W1964624702 @default.
• W2092608998 cites W1966792793 @default.
• W2092608998 cites W1967442749 @default.
• W2092608998 cites W1967867298 @default.
• W2092608998 cites W1973217384 @default.
• W2092608998 cites W1974507976 @default.
• W2092608998 cites W1984760727 @default.
• W2092608998 cites W2000738240 @default.
• W2092608998 cites W2005070242 @default.
• W2092608998 cites W2005413789 @default.
• W2092608998 cites W2007900684 @default.
• W2092608998 cites W2011127005 @default.
• W2092608998 cites W2013281318 @default.
• W2092608998 cites W2013570209 @default.
• W2092608998 cites W2019913278 @default.
• W2092608998 cites W2022982729 @default.
• W2092608998 cites W2023586132 @default.
• W2092608998 cites W2029952161 @default.
• W2092608998 cites W2046584040 @default.
• W2092608998 cites W2052661726 @default.
• W2092608998 cites W2057989750 @default.
• W2092608998 cites W2059613020 @default.
• W2092608998 cites W2062724886 @default.
• W2092608998 cites W2065685783 @default.
• W2092608998 cites W2067082060 @default.
• W2092608998 cites W2068112205 @default.
• W2092608998 cites W2075473225 @default.
• W2092608998 cites W2082454928 @default.
• W2092608998 cites W2087410169 @default.
• W2092608998 cites W2089493372 @default.
• W2092608998 cites W2089663037 @default.
• W2092608998 cites W2090160768 @default.
• W2092608998 cites W2094884053 @default.
• W2092608998 cites W2097439505 @default.
• W2092608998 cites W2107830208 @default.
• W2092608998 cites W2112368754 @default.
• W2092608998 cites W2120132994 @default.
• W2092608998 cites W2120600932 @default.
• W2092608998 cites W2122373218 @default.
• W2092608998 cites W2134579258 @default.
• W2092608998 cites W2137335872 @default.
• W2092608998 cites W2144258854 @default.
• W2092608998 cites W2146366544 @default.
• W2092608998 cites W2153974854 @default.
• W2092608998 cites W2155603822 @default.
• W2092608998 cites W2166708318 @default.
• W2092608998 cites W2170369801 @default.
• W2092608998 doi "https://doi.org/10.1042/bj20140881" @default.
• W2092608998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25422863" @default.
• W2092608998 hasPublicationYear "2015" @default.
• W2092608998 type Work @default.
• W2092608998 sameAs 2092608998 @default.
• W2092608998 citedByCount "74" @default.
• W2092608998 countsByYear W20926089982016 @default.
• W2092608998 countsByYear W20926089982017 @default.
• W2092608998 countsByYear W20926089982018 @default.
• W2092608998 countsByYear W20926089982019 @default.
• W2092608998 countsByYear W20926089982020 @default.
• W2092608998 countsByYear W20926089982021 @default.
• W2092608998 countsByYear W20926089982022 @default.
• W2092608998 countsByYear W20926089982023 @default.
• W2092608998 crossrefType "journal-article" @default.
• W2092608998 hasAuthorship W2092608998A5009737472 @default.
• W2092608998 hasAuthorship W2092608998A5024794283 @default.
• W2092608998 hasAuthorship W2092608998A5037220260 @default.
• W2092608998 hasAuthorship W2092608998A5043923263 @default.
• W2092608998 hasAuthorship W2092608998A5055432522 @default.
• W2092608998 hasAuthorship W2092608998A5061342475 @default.
• W2092608998 hasAuthorship W2092608998A5085818807 @default.
• W2092608998 hasAuthorship W2092608998A5087544909 @default.
• W2092608998 hasConcept C126322002 @default.
• W2092608998 hasConcept C134018914 @default.
• W2092608998 hasConcept C158617107 @default.
• W2092608998 hasConcept C162740809 @default.
• W2092608998 hasConcept C185592680 @default.
• W2092608998 hasConcept C202751555 @default.
• W2092608998 hasConcept C25095133 @default.
• W2092608998 hasConcept C2776175330 @default.
• W2092608998 hasConcept C2776200302 @default.
• W2092608998 hasConcept C2776610495 @default.
• W2092608998 hasConcept C2778772119 @default.
• W2092608998 hasConcept C2779134260 @default.

• next