FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092609093> ?p ?o ?g. }

• W2092609093 endingPage "8388" @default.
• W2092609093 startingPage "8382" @default.
• W2092609093 abstract "Abstract Transcriptional factor nuclear factor-κB (NF-κB) family has been shown to play an important role in tumor pathogenesis and serve as a potential target in cancer therapy. However, it is necessary to clarify the specific functions of NF-κB members, which would provide the basis for the selective blockade and reduction of therapeutic side effects resulting from unspecific inhibition of NF-κB members. In this study, we explored the role of NF-κB p105/p50 in melanoma pathogenesis in vitro and in vivo. We found that the expression of NF-κB p105/p50 significantly increased in dysplastic nevi, primary melanoma, and metastatic melanoma compared with normal nevi (P = 0.0004, χ2 test). Furthermore, NF-κB p105/p50 nuclear staining increased with melanoma progression and strong NF-κB p105/p50 nuclear staining was inversely correlated with disease-specific 5-year survival of patients with tumor thickness &gt;2.0 mm (P = 0.014, log-rank test). Multivariate Cox regression analysis revealed that nuclear expression of NF-κB p105/p50 is an independent prognostic factor in this subgroup. Moreover, we found that up-regulation of NF-κB p50 enhanced melanoma cell migration, whereas small interfering RNA knockdown inhibited cell migration. In addition, overexpression of NF-κB p50 induced RhoA activity and Rock-mediated formation of stress fiber in melanoma cells. Taken together, our data indicate that NF-κB p105/p50 may be an important marker for human melanoma progression and prognosis as well as a potentially selective therapeutic target. (Cancer Res 2006; 66(17): 8382-8)" @default.
• W2092609093 created "2016-06-24" @default.
• W2092609093 creator A5011353086 @default.
• W2092609093 creator A5011834043 @default.
• W2092609093 creator A5053400912 @default.
• W2092609093 creator A5074942308 @default.
• W2092609093 date "2006-09-01" @default.
• W2092609093 modified "2023-09-27" @default.
• W2092609093 title "Prognostic Significance of Nuclear Factor-κB p105/p50 in Human Melanoma and Its Role in Cell Migration" @default.
• W2092609093 cites W1486621660 @default.
• W2092609093 cites W1506569093 @default.
• W2092609093 cites W1528955439 @default.
• W2092609093 cites W1949238489 @default.
• W2092609093 cites W1970258245 @default.
• W2092609093 cites W1982062664 @default.
• W2092609093 cites W1986301169 @default.
• W2092609093 cites W1986637935 @default.
• W2092609093 cites W1991739120 @default.
• W2092609093 cites W1995757732 @default.
• W2092609093 cites W2003246798 @default.
• W2092609093 cites W2010397777 @default.
• W2092609093 cites W2012549345 @default.
• W2092609093 cites W2019405807 @default.
• W2092609093 cites W2031206331 @default.
• W2092609093 cites W2044573147 @default.
• W2092609093 cites W2051337269 @default.
• W2092609093 cites W2055080743 @default.
• W2092609093 cites W2063110724 @default.
• W2092609093 cites W2063220206 @default.
• W2092609093 cites W2067465277 @default.
• W2092609093 cites W2077080652 @default.
• W2092609093 cites W2092386908 @default.
• W2092609093 cites W2094586624 @default.
• W2092609093 cites W2096791952 @default.
• W2092609093 cites W2102312968 @default.
• W2092609093 cites W2102355180 @default.
• W2092609093 cites W2103230017 @default.
• W2092609093 cites W2117756942 @default.
• W2092609093 cites W2121001769 @default.
• W2092609093 cites W2129318139 @default.
• W2092609093 cites W2129696007 @default.
• W2092609093 cites W2130172628 @default.
• W2092609093 cites W2131365547 @default.
• W2092609093 cites W2152315800 @default.
• W2092609093 cites W2154655439 @default.
• W2092609093 cites W2160988670 @default.
• W2092609093 cites W2166766006 @default.
• W2092609093 cites W2168091755 @default.
• W2092609093 cites W2470223656 @default.
• W2092609093 cites W4235268961 @default.
• W2092609093 cites W4247325112 @default.
• W2092609093 cites W4256443839 @default.
• W2092609093 cites W4294990293 @default.
• W2092609093 cites W81987094 @default.
• W2092609093 cites W83885400 @default.
• W2092609093 doi "https://doi.org/10.1158/0008-5472.can-05-4402" @default.
• W2092609093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16951147" @default.
• W2092609093 hasPublicationYear "2006" @default.
• W2092609093 type Work @default.
• W2092609093 sameAs 2092609093 @default.
• W2092609093 citedByCount "38" @default.
• W2092609093 countsByYear W20926090932012 @default.
• W2092609093 countsByYear W20926090932013 @default.
• W2092609093 countsByYear W20926090932014 @default.
• W2092609093 countsByYear W20926090932015 @default.
• W2092609093 countsByYear W20926090932017 @default.
• W2092609093 countsByYear W20926090932019 @default.
• W2092609093 countsByYear W20926090932020 @default.
• W2092609093 countsByYear W20926090932021 @default.
• W2092609093 countsByYear W20926090932023 @default.
• W2092609093 crossrefType "journal-article" @default.
• W2092609093 hasAuthorship W2092609093A5011353086 @default.
• W2092609093 hasAuthorship W2092609093A5011834043 @default.
• W2092609093 hasAuthorship W2092609093A5053400912 @default.
• W2092609093 hasAuthorship W2092609093A5074942308 @default.
• W2092609093 hasBestOaLocation W20926090932 @default.
• W2092609093 hasConcept C104317684 @default.
• W2092609093 hasConcept C121608353 @default.
• W2092609093 hasConcept C123298856 @default.
• W2092609093 hasConcept C126322002 @default.
• W2092609093 hasConcept C142724271 @default.
• W2092609093 hasConcept C1491633281 @default.
• W2092609093 hasConcept C173396325 @default.
• W2092609093 hasConcept C203014093 @default.
• W2092609093 hasConcept C2776914184 @default.
• W2092609093 hasConcept C2777658100 @default.
• W2092609093 hasConcept C2777730290 @default.
• W2092609093 hasConcept C2780942790 @default.
• W2092609093 hasConcept C502942594 @default.
• W2092609093 hasConcept C54355233 @default.
• W2092609093 hasConcept C71924100 @default.
• W2092609093 hasConcept C81885089 @default.
• W2092609093 hasConcept C86339819 @default.
• W2092609093 hasConcept C86803240 @default.
• W2092609093 hasConcept C98270193 @default.
• W2092609093 hasConceptScore W2092609093C104317684 @default.
• W2092609093 hasConceptScore W2092609093C121608353 @default.
• W2092609093 hasConceptScore W2092609093C123298856 @default.

• next