Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092635169> ?p ?o ?g. }
- W2092635169 endingPage "1776" @default.
- W2092635169 startingPage "1768" @default.
- W2092635169 abstract "Mumps virus (MuV) causes an acute infection in humans characterized by a wide array of symptoms ranging from relatively mild manifestations, such as parotitis, to more-severe complications, such as meningitis and encephalitis. Widespread mumps vaccination has reduced mumps incidence dramatically; however, outbreaks still occur in vaccinated populations. The V protein of MuV, when expressed in cell culture, blocks interferon (IFN) expression and signaling and interleukin-6 (IL-6) signaling. In this work, we generated a recombinant MuV incapable of expressing the V protein (rMuVΔV). The rescued MuV was derived from a clinical wild-type isolate from a recent outbreak in the United States (MuV(Iowa/US/06), G genotype). Analysis of the virus confirmed the roles of V protein in blocking IFN expression and signaling and IL-6 signaling. We also found that the rMuV(Iowa/US/06)ΔV virus induced high levels of IL-6 expression in vitro, suggesting that V plays a role in reducing IL-6 expression. In vivo, the rMuV(Iowa/US/06)ΔV virus was highly attenuated, indicating that the V protein plays an essential role in viral virulence." @default.
- W2092635169 created "2016-06-24" @default.
- W2092635169 creator A5001526364 @default.
- W2092635169 creator A5015495850 @default.
- W2092635169 creator A5017058988 @default.
- W2092635169 creator A5042932744 @default.
- W2092635169 creator A5043329824 @default.
- W2092635169 creator A5044249476 @default.
- W2092635169 creator A5069719518 @default.
- W2092635169 creator A5080931087 @default.
- W2092635169 creator A5081411724 @default.
- W2092635169 date "2012-02-01" @default.
- W2092635169 modified "2023-09-27" @default.
- W2092635169 title "The V Protein of Mumps Virus Plays a Critical Role in Pathogenesis" @default.
- W2092635169 cites W10619481 @default.
- W2092635169 cites W1530867604 @default.
- W2092635169 cites W1810300540 @default.
- W2092635169 cites W1969689219 @default.
- W2092635169 cites W1983374949 @default.
- W2092635169 cites W1993618642 @default.
- W2092635169 cites W1997432096 @default.
- W2092635169 cites W1997858324 @default.
- W2092635169 cites W2012746154 @default.
- W2092635169 cites W2018826287 @default.
- W2092635169 cites W2023923107 @default.
- W2092635169 cites W2024054563 @default.
- W2092635169 cites W2034134903 @default.
- W2092635169 cites W2036264424 @default.
- W2092635169 cites W2040545193 @default.
- W2092635169 cites W2043152280 @default.
- W2092635169 cites W2046900681 @default.
- W2092635169 cites W2053808195 @default.
- W2092635169 cites W2061786577 @default.
- W2092635169 cites W2069223086 @default.
- W2092635169 cites W2077102904 @default.
- W2092635169 cites W2085638097 @default.
- W2092635169 cites W2085773790 @default.
- W2092635169 cites W2094911949 @default.
- W2092635169 cites W2098918789 @default.
- W2092635169 cites W2101525702 @default.
- W2092635169 cites W2104066808 @default.
- W2092635169 cites W2104221111 @default.
- W2092635169 cites W2124913228 @default.
- W2092635169 cites W2125869616 @default.
- W2092635169 cites W2126403192 @default.
- W2092635169 cites W2127228010 @default.
- W2092635169 cites W2127918959 @default.
- W2092635169 cites W2152433346 @default.
- W2092635169 cites W2159232188 @default.
- W2092635169 cites W2165849880 @default.
- W2092635169 cites W2170063337 @default.
- W2092635169 cites W2172110172 @default.
- W2092635169 cites W92485366 @default.
- W2092635169 doi "https://doi.org/10.1128/jvi.06019-11" @default.
- W2092635169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3264346" @default.
- W2092635169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22090137" @default.
- W2092635169 hasPublicationYear "2012" @default.
- W2092635169 type Work @default.
- W2092635169 sameAs 2092635169 @default.
- W2092635169 citedByCount "34" @default.
- W2092635169 countsByYear W20926351692013 @default.
- W2092635169 countsByYear W20926351692014 @default.
- W2092635169 countsByYear W20926351692015 @default.
- W2092635169 countsByYear W20926351692016 @default.
- W2092635169 countsByYear W20926351692017 @default.
- W2092635169 countsByYear W20926351692018 @default.
- W2092635169 countsByYear W20926351692019 @default.
- W2092635169 countsByYear W20926351692020 @default.
- W2092635169 countsByYear W20926351692022 @default.
- W2092635169 countsByYear W20926351692023 @default.
- W2092635169 crossrefType "journal-article" @default.
- W2092635169 hasAuthorship W2092635169A5001526364 @default.
- W2092635169 hasAuthorship W2092635169A5015495850 @default.
- W2092635169 hasAuthorship W2092635169A5017058988 @default.
- W2092635169 hasAuthorship W2092635169A5042932744 @default.
- W2092635169 hasAuthorship W2092635169A5043329824 @default.
- W2092635169 hasAuthorship W2092635169A5044249476 @default.
- W2092635169 hasAuthorship W2092635169A5069719518 @default.
- W2092635169 hasAuthorship W2092635169A5080931087 @default.
- W2092635169 hasAuthorship W2092635169A5081411724 @default.
- W2092635169 hasBestOaLocation W20926351691 @default.
- W2092635169 hasConcept C116675565 @default.
- W2092635169 hasConcept C159047783 @default.
- W2092635169 hasConcept C203014093 @default.
- W2092635169 hasConcept C22070199 @default.
- W2092635169 hasConcept C2522874641 @default.
- W2092635169 hasConcept C2776178377 @default.
- W2092635169 hasConcept C2776438120 @default.
- W2092635169 hasConcept C2776672420 @default.
- W2092635169 hasConcept C2778538096 @default.
- W2092635169 hasConcept C2780657872 @default.
- W2092635169 hasConcept C2780942790 @default.
- W2092635169 hasConcept C83455156 @default.
- W2092635169 hasConcept C86803240 @default.
- W2092635169 hasConceptScore W2092635169C116675565 @default.
- W2092635169 hasConceptScore W2092635169C159047783 @default.
- W2092635169 hasConceptScore W2092635169C203014093 @default.
- W2092635169 hasConceptScore W2092635169C22070199 @default.