Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092642626> ?p ?o ?g. }
- W2092642626 endingPage "2735" @default.
- W2092642626 startingPage "2729" @default.
- W2092642626 abstract "Our group has recently demonstrated the overexpression of the UbcH10 gene in undifferentiated thyroid carcinomas. Subsequently, a clear correlation between UbcH10 overexpression and a reduced survival in ovarian carcinoma patients has been described indicating UbcH10 as a valid prognostic marker in this neoplastic disease. Here we have extended the analysis of the UbcH10 expression to neoplastic breast diseases. We demonstrated, by tissue micro-arrays immunohistochemical studies, a significant difference (p=0.0001) in the mean percentage of UbcH10 stained cells between benign (0.22%) and malignant (11.01%) neoplastic lesions. High UbcH10 expression was associated with intense Ki-67 staining (p=0.015) and ErbB2 positivity (p=0.092). The suppression of the ErbB2 expression in breast carcinoma cell lines induces a reduction of UbcH10 level. Consistently, the inhibition of breast carcinoma cell growth was achieved following the block of UbcH10 protein synthesis by RNA interference. Therefore, these results suggest the perspective of a therapy of aggressive breast carcinomas based on the suppression of the UbcH10 function." @default.
- W2092642626 created "2016-06-24" @default.
- W2092642626 creator A5007157411 @default.
- W2092642626 creator A5012721453 @default.
- W2092642626 creator A5032330087 @default.
- W2092642626 creator A5039934649 @default.
- W2092642626 creator A5047395289 @default.
- W2092642626 creator A5058355059 @default.
- W2092642626 creator A5065632326 @default.
- W2092642626 creator A5075032969 @default.
- W2092642626 creator A5080238293 @default.
- W2092642626 creator A5081257602 @default.
- W2092642626 creator A5085357602 @default.
- W2092642626 date "2007-12-01" @default.
- W2092642626 modified "2023-10-15" @default.
- W2092642626 title "UbcH10 is overexpressed in malignant breast carcinomas" @default.
- W2092642626 cites W1970355929 @default.
- W2092642626 cites W1996153208 @default.
- W2092642626 cites W1999550353 @default.
- W2092642626 cites W2003626177 @default.
- W2092642626 cites W2022376508 @default.
- W2092642626 cites W2037067862 @default.
- W2092642626 cites W2054289297 @default.
- W2092642626 cites W2097384171 @default.
- W2092642626 cites W2106484028 @default.
- W2092642626 cites W2124371549 @default.
- W2092642626 cites W2131530904 @default.
- W2092642626 cites W2138591711 @default.
- W2092642626 cites W2152759249 @default.
- W2092642626 cites W2166987747 @default.
- W2092642626 doi "https://doi.org/10.1016/j.ejca.2007.09.003" @default.
- W2092642626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17933517" @default.
- W2092642626 hasPublicationYear "2007" @default.
- W2092642626 type Work @default.
- W2092642626 sameAs 2092642626 @default.
- W2092642626 citedByCount "61" @default.
- W2092642626 countsByYear W20926426262012 @default.
- W2092642626 countsByYear W20926426262013 @default.
- W2092642626 countsByYear W20926426262014 @default.
- W2092642626 countsByYear W20926426262015 @default.
- W2092642626 countsByYear W20926426262016 @default.
- W2092642626 countsByYear W20926426262017 @default.
- W2092642626 countsByYear W20926426262018 @default.
- W2092642626 countsByYear W20926426262019 @default.
- W2092642626 countsByYear W20926426262020 @default.
- W2092642626 countsByYear W20926426262021 @default.
- W2092642626 countsByYear W20926426262022 @default.
- W2092642626 crossrefType "journal-article" @default.
- W2092642626 hasAuthorship W2092642626A5007157411 @default.
- W2092642626 hasAuthorship W2092642626A5012721453 @default.
- W2092642626 hasAuthorship W2092642626A5032330087 @default.
- W2092642626 hasAuthorship W2092642626A5039934649 @default.
- W2092642626 hasAuthorship W2092642626A5047395289 @default.
- W2092642626 hasAuthorship W2092642626A5058355059 @default.
- W2092642626 hasAuthorship W2092642626A5065632326 @default.
- W2092642626 hasAuthorship W2092642626A5075032969 @default.
- W2092642626 hasAuthorship W2092642626A5080238293 @default.
- W2092642626 hasAuthorship W2092642626A5081257602 @default.
- W2092642626 hasAuthorship W2092642626A5085357602 @default.
- W2092642626 hasConcept C121608353 @default.
- W2092642626 hasConcept C126322002 @default.
- W2092642626 hasConcept C142724271 @default.
- W2092642626 hasConcept C204232928 @default.
- W2092642626 hasConcept C2777546739 @default.
- W2092642626 hasConcept C3018521938 @default.
- W2092642626 hasConcept C502942594 @default.
- W2092642626 hasConcept C530470458 @default.
- W2092642626 hasConcept C71924100 @default.
- W2092642626 hasConcept C86803240 @default.
- W2092642626 hasConceptScore W2092642626C121608353 @default.
- W2092642626 hasConceptScore W2092642626C126322002 @default.
- W2092642626 hasConceptScore W2092642626C142724271 @default.
- W2092642626 hasConceptScore W2092642626C204232928 @default.
- W2092642626 hasConceptScore W2092642626C2777546739 @default.
- W2092642626 hasConceptScore W2092642626C3018521938 @default.
- W2092642626 hasConceptScore W2092642626C502942594 @default.
- W2092642626 hasConceptScore W2092642626C530470458 @default.
- W2092642626 hasConceptScore W2092642626C71924100 @default.
- W2092642626 hasConceptScore W2092642626C86803240 @default.
- W2092642626 hasIssue "18" @default.
- W2092642626 hasLocation W20926426261 @default.
- W2092642626 hasLocation W20926426262 @default.
- W2092642626 hasOpenAccess W2092642626 @default.
- W2092642626 hasPrimaryLocation W20926426261 @default.
- W2092642626 hasRelatedWork W2001030974 @default.
- W2092642626 hasRelatedWork W2113335236 @default.
- W2092642626 hasRelatedWork W2328395017 @default.
- W2092642626 hasRelatedWork W2355920994 @default.
- W2092642626 hasRelatedWork W2373084812 @default.
- W2092642626 hasRelatedWork W2376996112 @default.
- W2092642626 hasRelatedWork W2399421402 @default.
- W2092642626 hasRelatedWork W2410574247 @default.
- W2092642626 hasRelatedWork W2616467897 @default.
- W2092642626 hasRelatedWork W2999877485 @default.
- W2092642626 hasVolume "43" @default.
- W2092642626 isParatext "false" @default.
- W2092642626 isRetracted "false" @default.
- W2092642626 magId "2092642626" @default.