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• W2092643485 abstract "Female SWR mice were treated with 1,2-dimethylhydrazine (DMH: 6.8 mg/kg i.p. injection) once weekly for up to 10 weeks, a dosing regime that produced tumours principally within the distal colon (Jackson et al., 1999. Carcinogenesis 20, 509–513). O6-Methylguanine (O6-MeG) levels, measured using a simple [3H]-based O6-alkylguanine-DNA alkyltransferase (ATase) inactivation assay, ranged from 0.6 to 16.7 fmol/μg DNA with: (i) highest levels in the distal colon; and (ii) higher levels after 68 mg/kg total DMH than 6.8 mg/kg DMH. Basal ATase activity varied between 0.97 and 1.22 fmol/μg DNA within the colon but was not associated with adduct levels or tumour induction. After 6.8 mg/kg DMH, the half life of O6-MeG in colonic tissue was 36–42 h whereas after 68 mg/kg DMH, t1/2 was approximately 25, 57 and 96 h in the proximal, mid and distal colon, respectively. Tumour induction was thus associated with the levels and persistence of O6-MeG in the distal colon." @default.
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• W2092643485 date "2000-06-01" @default.
• W2092643485 modified "2023-10-01" @default.
• W2092643485 title "Formation and persistence of O6-methylguanine in the mouse colon following treatment with 1,2-dimethylhydrazine as measured by an O6-alkylguanine-DNA alkyltransferase inactivation assay" @default.
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• W2092643485 doi "https://doi.org/10.1016/s0378-4274(00)00193-4" @default.
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