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- W2092644120 abstract "Abstract The centromeric region of the X chromosome in humans experiences low rates of recombination over a considerable physical distance. In such a region, the effects of selection may extend to linked sites that are far away. To investigate the effects of this recombinational environment on patterns of nucleotide variability, we sequenced 4581 bp at Msn and 4697 bp at Alas2, two genes situated on either side of the X chromosome centromere, in a worldwide sample of 41 men, as well as in one common chimpanzee and one orangutan. To investigate patterns of linkage disequilibrium (LD) across the centromere, we also genotyped several informative sites from each gene in 120 men from sub-Saharan Africa. By studying X-linked loci in males, we were able to recover haplotypes and study long-range patterns of LD directly. Overall patterns of variability were remarkably similar at these two loci. Both loci exhibited (i) very low levels of nucleotide diversity (among the lowest seen in the human genome); (ii) a strong skew in the distribution of allele frequencies, with an excess of both very-low and very-high-frequency derived alleles in non-African populations; (iii) much less variation in the non-African than in the African samples; (iv) very high levels of population differentiation; and (v) complete LD among all sites within loci. We also observed significant LD between Msn and Alas2 in Africa, despite the fact that they are separated by ∼10 Mb. These observations are difficult to reconcile with a simple demographic model but may be consistent with positive and/or purifying selection acting on loci within this large region of low recombination." @default.
- W2092644120 created "2016-06-24" @default.
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- W2092644120 date "2004-05-01" @default.
- W2092644120 modified "2023-10-17" @default.
- W2092644120 title "Nucleotide Variation at Msn and Alas2, Two Genes Flanking the Centromere of the X Chromosome in Humans" @default.
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- W2092644120 cites W1523562895 @default.
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- W2092644120 cites W1824635757 @default.
- W2092644120 cites W1840856309 @default.
- W2092644120 cites W1892029173 @default.
- W2092644120 cites W1911384112 @default.
- W2092644120 cites W1919772617 @default.
- W2092644120 cites W1920574182 @default.
- W2092644120 cites W1932538605 @default.
- W2092644120 cites W1947714123 @default.
- W2092644120 cites W1971604012 @default.
- W2092644120 cites W1974466989 @default.
- W2092644120 cites W1974523504 @default.
- W2092644120 cites W1981783986 @default.
- W2092644120 cites W1982663312 @default.
- W2092644120 cites W1984390786 @default.
- W2092644120 cites W1984921840 @default.
- W2092644120 cites W1985270495 @default.
- W2092644120 cites W1985629031 @default.
- W2092644120 cites W1998197559 @default.
- W2092644120 cites W2005935256 @default.
- W2092644120 cites W2008321551 @default.
- W2092644120 cites W2022005040 @default.
- W2092644120 cites W2025306791 @default.
- W2092644120 cites W2026351754 @default.
- W2092644120 cites W2034078054 @default.
- W2092644120 cites W2042529907 @default.
- W2092644120 cites W2047222949 @default.
- W2092644120 cites W2051583712 @default.
- W2092644120 cites W2055543630 @default.
- W2092644120 cites W2062963521 @default.
- W2092644120 cites W2072889251 @default.
- W2092644120 cites W2073968357 @default.
- W2092644120 cites W2079600652 @default.
- W2092644120 cites W2082967637 @default.
- W2092644120 cites W2085152875 @default.
- W2092644120 cites W2085221932 @default.
- W2092644120 cites W2087244792 @default.
- W2092644120 cites W2090906017 @default.
- W2092644120 cites W2102668767 @default.
- W2092644120 cites W2104743461 @default.
- W2092644120 cites W2107934935 @default.
- W2092644120 cites W2113157530 @default.
- W2092644120 cites W2117553956 @default.
- W2092644120 cites W2122004833 @default.
- W2092644120 cites W2123797367 @default.
- W2092644120 cites W2125685565 @default.
- W2092644120 cites W2126204254 @default.
- W2092644120 cites W2127230663 @default.
- W2092644120 cites W2129403396 @default.
- W2092644120 cites W2129505973 @default.
- W2092644120 cites W2129606654 @default.
- W2092644120 cites W2132393729 @default.
- W2092644120 cites W2133312667 @default.
- W2092644120 cites W2135588481 @default.
- W2092644120 cites W2135732313 @default.
- W2092644120 cites W2140784970 @default.
- W2092644120 cites W2148896102 @default.
- W2092644120 cites W2149318232 @default.
- W2092644120 cites W2149943693 @default.
- W2092644120 cites W2151464048 @default.
- W2092644120 cites W2152775760 @default.
- W2092644120 cites W2155670634 @default.
- W2092644120 cites W2155967582 @default.
- W2092644120 cites W2157149092 @default.
- W2092644120 cites W2157793907 @default.
- W2092644120 cites W2161425930 @default.
- W2092644120 cites W2162790718 @default.
- W2092644120 cites W2163600007 @default.
- W2092644120 cites W2165453594 @default.
- W2092644120 cites W2168909179 @default.
- W2092644120 cites W2170937702 @default.
- W2092644120 cites W2185775644 @default.
- W2092644120 cites W2266924175 @default.
- W2092644120 cites W4251304755 @default.
- W2092644120 doi "https://doi.org/10.1534/genetics.167.1.423" @default.
- W2092644120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1470878" @default.
- W2092644120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15166166" @default.
- W2092644120 hasPublicationYear "2004" @default.
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