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• W2092656894 abstract "The common cytokine receptor gamma chain (gammac), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic domain of gammac consists of 85 aa, in which the carboxyl-terminal 48 aa are essential for its interaction with and activation of the Janus kinase, Jak3. Evidence has been provided that Jak3-independent signals might be transmitted via the residual membrane-proximal region; however, its role in vivo remains totally unknown. In the present study, we expressed mutant forms of gammac, which lack either most of the cytoplasmic domain or only the membrane-distal Jak3-binding region, on a gammac null background. We demonstrate that, unlike gammac or Jak3 null mice, expression of the latter, but not the former mutant, restores T lymphopoiesis in vivo, accompanied by strong expression of Bcl-2. On the other hand, the in vitro functions of the restored T cells still remained impaired. These results not only reveal the hitherto unknown role of the gammac membrane-proximal region, but also suggest the differential requirement of the cytoplasmic subregions of gammac in T cell development and function." @default.
• W2092656894 created "2016-06-24" @default.
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• W2092656894 date "2000-08-29" @default.
• W2092656894 modified "2023-10-18" @default.
• W2092656894 title "Differential requirement of the cytoplasmic subregions of γc chain in T cell development and function" @default.
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• W2092656894 doi "https://doi.org/10.1073/pnas.180063297" @default.
• W2092656894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/27056" @default.
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