Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092673229> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2092673229 endingPage "979" @default.
- W2092673229 startingPage "971" @default.
- W2092673229 abstract "Triazolam pharmacokinetics and effects on sedation, short-term amnesia, and psychomotor performance were evaluated in 25 normal volunteers as part of a safety and tolerance study of intravenous dosing of triazolam. Triazolam kinetics were linear after intravenous administration of doses up to 1.0 mg with no differences among doses in elimination half-life, volume of distribution, or clearance. The hepatic extraction ratio ranged from 0.14 to 0.37, suggesting that triazolam should undergo moderate first-pass metabolism after oral administration. The duration and extent of sedation, decrement in psychomotor performance test scores, and amnesia were dose related, but all subjects returned to baseline alertness and function within eight hours of dosing. The time-course of effects on memory and psychomotor performance were related to triazolam plasma concentration profile using an Emax model for effect and a two-compartment pharmacokinetic model. The probability of a subject being asleep was related to triazolam plasma concentrations using logistic regression. These models indicate that intravenous doses of 0.25 to 0.5 mg triazolam would be effective for use preoperatively for short surgical procedures." @default.
- W2092673229 created "2016-06-24" @default.
- W2092673229 creator A5030876540 @default.
- W2092673229 creator A5066531946 @default.
- W2092673229 creator A5068273065 @default.
- W2092673229 date "1987-12-01" @default.
- W2092673229 modified "2023-09-27" @default.
- W2092673229 title "Pharmacodynamics of Triazolam After Intravenous Administration" @default.
- W2092673229 cites W1979856161 @default.
- W2092673229 cites W1979886938 @default.
- W2092673229 cites W2013023901 @default.
- W2092673229 cites W2027864018 @default.
- W2092673229 cites W2030368536 @default.
- W2092673229 cites W2068298897 @default.
- W2092673229 cites W2071418888 @default.
- W2092673229 cites W2079055954 @default.
- W2092673229 cites W2156111856 @default.
- W2092673229 cites W4252990426 @default.
- W2092673229 doi "https://doi.org/10.1002/j.1552-4604.1987.tb05599.x" @default.
- W2092673229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3437069" @default.
- W2092673229 hasPublicationYear "1987" @default.
- W2092673229 type Work @default.
- W2092673229 sameAs 2092673229 @default.
- W2092673229 citedByCount "36" @default.
- W2092673229 countsByYear W20926732292023 @default.
- W2092673229 crossrefType "journal-article" @default.
- W2092673229 hasAuthorship W2092673229A5030876540 @default.
- W2092673229 hasAuthorship W2092673229A5066531946 @default.
- W2092673229 hasAuthorship W2092673229A5068273065 @default.
- W2092673229 hasConcept C111113717 @default.
- W2092673229 hasConcept C112705442 @default.
- W2092673229 hasConcept C118552586 @default.
- W2092673229 hasConcept C126322002 @default.
- W2092673229 hasConcept C139254425 @default.
- W2092673229 hasConcept C164953862 @default.
- W2092673229 hasConcept C169900460 @default.
- W2092673229 hasConcept C170493617 @default.
- W2092673229 hasConcept C2776814716 @default.
- W2092673229 hasConcept C2777288759 @default.
- W2092673229 hasConcept C2777602617 @default.
- W2092673229 hasConcept C2778173252 @default.
- W2092673229 hasConcept C2778615406 @default.
- W2092673229 hasConcept C2779738154 @default.
- W2092673229 hasConcept C2780930544 @default.
- W2092673229 hasConcept C42219234 @default.
- W2092673229 hasConcept C71924100 @default.
- W2092673229 hasConcept C98274493 @default.
- W2092673229 hasConceptScore W2092673229C111113717 @default.
- W2092673229 hasConceptScore W2092673229C112705442 @default.
- W2092673229 hasConceptScore W2092673229C118552586 @default.
- W2092673229 hasConceptScore W2092673229C126322002 @default.
- W2092673229 hasConceptScore W2092673229C139254425 @default.
- W2092673229 hasConceptScore W2092673229C164953862 @default.
- W2092673229 hasConceptScore W2092673229C169900460 @default.
- W2092673229 hasConceptScore W2092673229C170493617 @default.
- W2092673229 hasConceptScore W2092673229C2776814716 @default.
- W2092673229 hasConceptScore W2092673229C2777288759 @default.
- W2092673229 hasConceptScore W2092673229C2777602617 @default.
- W2092673229 hasConceptScore W2092673229C2778173252 @default.
- W2092673229 hasConceptScore W2092673229C2778615406 @default.
- W2092673229 hasConceptScore W2092673229C2779738154 @default.
- W2092673229 hasConceptScore W2092673229C2780930544 @default.
- W2092673229 hasConceptScore W2092673229C42219234 @default.
- W2092673229 hasConceptScore W2092673229C71924100 @default.
- W2092673229 hasConceptScore W2092673229C98274493 @default.
- W2092673229 hasIssue "12" @default.
- W2092673229 hasLocation W20926732291 @default.
- W2092673229 hasLocation W20926732292 @default.
- W2092673229 hasOpenAccess W2092673229 @default.
- W2092673229 hasPrimaryLocation W20926732291 @default.
- W2092673229 hasRelatedWork W2018219218 @default.
- W2092673229 hasRelatedWork W2029227957 @default.
- W2092673229 hasRelatedWork W2060138724 @default.
- W2092673229 hasRelatedWork W2072892832 @default.
- W2092673229 hasRelatedWork W2077579315 @default.
- W2092673229 hasRelatedWork W2130538431 @default.
- W2092673229 hasRelatedWork W2380205709 @default.
- W2092673229 hasRelatedWork W2411528523 @default.
- W2092673229 hasRelatedWork W2597312724 @default.
- W2092673229 hasRelatedWork W3146388768 @default.
- W2092673229 hasVolume "27" @default.
- W2092673229 isParatext "false" @default.
- W2092673229 isRetracted "false" @default.
- W2092673229 magId "2092673229" @default.
- W2092673229 workType "article" @default.