FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092676389> ?p ?o ?g. }

• W2092676389 endingPage "2735" @default.
• W2092676389 startingPage "2727" @default.
• W2092676389 abstract "Allograft rejection is mainly driven by the production of IL-2, which expands T cells by linking the IL-2 receptor (IL-2R) composed of three subunits: CD25, CD122 and CD132. Daclizumab, widely used in immunosuppression, is a humanized anti-CD25 antibody that disrupts IL-2 signaling by binding to CD25 and preventing the assembly of the high-affinity IL-2R. Here we show that Daclizumab, while blocking the T-cell response to IL-2, increases CD4(+) and CD8(+) T-cell proliferative response to the homeostatic cytokine IL-7. The IL-7R shares CD132 with the IL-2R and blocking of CD25 by Daclizumab results in the enhanced formation of the IL-7R that in turn allows IL-7 to bind more efficiently on the cell surface. The consequently increased IL-7R signaling boosts intracellular phosphorylated STAT5 and T-cell proliferation. In addition, treatment with Daclizumab delays the internalization of CD127 upon IL-7 treatment, retaining T-cell sensitivity to IL-7 for a prolonged time. This effect of Daclizumab highlights the redundancy of the cytokine system, which may influence T-cell proliferation in transplanted patients, and provides information to improve future immunosuppressive strategies." @default.
• W2092676389 created "2016-06-24" @default.
• W2092676389 creator A5026837875 @default.
• W2092676389 creator A5032653514 @default.
• W2092676389 creator A5038867918 @default.
• W2092676389 creator A5080075740 @default.
• W2092676389 creator A5088240585 @default.
• W2092676389 date "2009-12-01" @default.
• W2092676389 modified "2023-09-29" @default.
• W2092676389 title "Disengaging the IL-2 Receptor with Daclizumab Enhances IL-7–Mediated Proliferation of CD4+ and CD8+ T Cells" @default.
• W2092676389 cites W1515251449 @default.
• W2092676389 cites W1964951622 @default.
• W2092676389 cites W1976947891 @default.
• W2092676389 cites W1985570047 @default.
• W2092676389 cites W2001709426 @default.
• W2092676389 cites W2004151989 @default.
• W2092676389 cites W2006561389 @default.
• W2092676389 cites W2015955149 @default.
• W2092676389 cites W2039527859 @default.
• W2092676389 cites W2052150715 @default.
• W2092676389 cites W2059412913 @default.
• W2092676389 cites W2091824579 @default.
• W2092676389 cites W2119080021 @default.
• W2092676389 cites W2120941256 @default.
• W2092676389 cites W2148473794 @default.
• W2092676389 cites W2156964052 @default.
• W2092676389 cites W2159584193 @default.
• W2092676389 cites W2168628806 @default.
• W2092676389 cites W2170515238 @default.
• W2092676389 cites W68282923 @default.
• W2092676389 doi "https://doi.org/10.1111/j.1600-6143.2009.02825.x" @default.
• W2092676389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19788505" @default.
• W2092676389 hasPublicationYear "2009" @default.
• W2092676389 type Work @default.
• W2092676389 sameAs 2092676389 @default.
• W2092676389 citedByCount "21" @default.
• W2092676389 countsByYear W20926763892012 @default.
• W2092676389 countsByYear W20926763892013 @default.
• W2092676389 countsByYear W20926763892014 @default.
• W2092676389 countsByYear W20926763892015 @default.
• W2092676389 countsByYear W20926763892016 @default.
• W2092676389 countsByYear W20926763892017 @default.
• W2092676389 countsByYear W20926763892018 @default.
• W2092676389 countsByYear W20926763892019 @default.
• W2092676389 countsByYear W20926763892020 @default.
• W2092676389 countsByYear W20926763892022 @default.
• W2092676389 countsByYear W20926763892023 @default.
• W2092676389 crossrefType "journal-article" @default.
• W2092676389 hasAuthorship W2092676389A5026837875 @default.
• W2092676389 hasAuthorship W2092676389A5032653514 @default.
• W2092676389 hasAuthorship W2092676389A5038867918 @default.
• W2092676389 hasAuthorship W2092676389A5080075740 @default.
• W2092676389 hasAuthorship W2092676389A5088240585 @default.
• W2092676389 hasConcept C123982805 @default.
• W2092676389 hasConcept C154317977 @default.
• W2092676389 hasConcept C159654299 @default.
• W2092676389 hasConcept C167672396 @default.
• W2092676389 hasConcept C202751555 @default.
• W2092676389 hasConcept C203014093 @default.
• W2092676389 hasConcept C2776090121 @default.
• W2092676389 hasConcept C2777371288 @default.
• W2092676389 hasConcept C2778690821 @default.
• W2092676389 hasConcept C2779719350 @default.
• W2092676389 hasConcept C502942594 @default.
• W2092676389 hasConcept C542903549 @default.
• W2092676389 hasConcept C55493867 @default.
• W2092676389 hasConcept C71924100 @default.
• W2092676389 hasConcept C79484868 @default.
• W2092676389 hasConcept C86803240 @default.
• W2092676389 hasConcept C8891405 @default.
• W2092676389 hasConcept C95444343 @default.
• W2092676389 hasConceptScore W2092676389C123982805 @default.
• W2092676389 hasConceptScore W2092676389C154317977 @default.
• W2092676389 hasConceptScore W2092676389C159654299 @default.
• W2092676389 hasConceptScore W2092676389C167672396 @default.
• W2092676389 hasConceptScore W2092676389C202751555 @default.
• W2092676389 hasConceptScore W2092676389C203014093 @default.
• W2092676389 hasConceptScore W2092676389C2776090121 @default.
• W2092676389 hasConceptScore W2092676389C2777371288 @default.
• W2092676389 hasConceptScore W2092676389C2778690821 @default.
• W2092676389 hasConceptScore W2092676389C2779719350 @default.
• W2092676389 hasConceptScore W2092676389C502942594 @default.
• W2092676389 hasConceptScore W2092676389C542903549 @default.
• W2092676389 hasConceptScore W2092676389C55493867 @default.
• W2092676389 hasConceptScore W2092676389C71924100 @default.
• W2092676389 hasConceptScore W2092676389C79484868 @default.
• W2092676389 hasConceptScore W2092676389C86803240 @default.
• W2092676389 hasConceptScore W2092676389C8891405 @default.
• W2092676389 hasConceptScore W2092676389C95444343 @default.
• W2092676389 hasIssue "12" @default.
• W2092676389 hasLocation W20926763891 @default.
• W2092676389 hasLocation W20926763892 @default.
• W2092676389 hasOpenAccess W2092676389 @default.
• W2092676389 hasPrimaryLocation W20926763891 @default.
• W2092676389 hasRelatedWork W1568830440 @default.
• W2092676389 hasRelatedWork W1571952624 @default.
• W2092676389 hasRelatedWork W1915412223 @default.
• W2092676389 hasRelatedWork W2063492259 @default.

• next