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- W2092678081 abstract "Differentiation and activation of fibroblasts into myofibroblasts which express α-smooth muscle actin (α-SMA) are essential for wound healing and tissue repair. Change in fibroblast properties is initiated by transforming growth factor β (TGF-β). Here, we sought to investigate whether connexin43 (Cx43), a gap-junctional protein, contributes to differentiation of cardiac fibroblasts to myofibroblasts. In cultured neonatal rat cardiac fibroblasts, we found that expression of α-SMA increases in parallel with Cx43 by using immunocytochemistry, and that knockdown of the endogenous Cx43 activity with antisense oligodeoxynucleotides (AS) inhibits α-SMA expression significantly, while overexpression of Cx43 increases α-SMA expression remarkably. These findings demonstrate that Cx43 contributes to TGF-β signaling to regulate α-SMA expression. Thus, we propose a novel physiologic function of Cx43, which plays a critical role in the pathological activation of cardiac fibroblasts in the myocardial fibrosis associated with heart failure." @default.
- W2092678081 created "2016-06-24" @default.
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- W2092678081 date "2009-04-01" @default.
- W2092678081 modified "2023-10-16" @default.
- W2092678081 title "Cx43 contributes to TGF-β signaling to regulate differentiation of cardiac fibroblasts into myofibroblasts" @default.
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- W2092678081 doi "https://doi.org/10.1016/j.yexcr.2008.12.021" @default.
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