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- W2092683282 abstract "Abstract In this study, we investigated how regularities in time and in sequence affect on mismatched negativity (MMN) in persons with intellectual disabilities. Subjects were 10 normal adults (age: 22–26 years) and eight adults with intellectual disabilities (age: 28–46 years, IQ: 38–55). While the subjects engaged to watch a silent video program, stimulus tone was delivered through the speaker. Pip tone in 1000 Hz was used as a frequent stimulus with a probability of 0.8 and in 1050 Hz as a deviant stimulus with a probability of 0.2. Every combination of stimulus sequence (Regular vs. oddball) and Inter-Stimulus Intervals (ISI, fixed vs. random) were used as stimulus series. N1 component was observed in ERP in normal adult subjects. Then, P2 component followed in ERP by standard stimulus, but with reduced amplitude in ERP by deviant stimulus. These potential differences between ERP by standard and by deviant stimuli were observed in the map series with anterior dominant MMN. Compared to MMN in regular series, a larger amplitude of MMN in oddball series was remarkable. The N1 component was also observed in the ERP in persons with intellectual disabilities. However, map series of subtracted ERP in persons with intellectual disabilities indicate poorer MMN in oddball series with fixed ISI and no MMN in the remaining three conditions. Therefore, longer sequence of standard stimuli with fixed timing will be needed to establish a memory trace in automatic auditory information processing in persons with intellectual disabilities." @default.
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- W2092683282 date "2002-04-01" @default.
- W2092683282 modified "2023-09-27" @default.
- W2092683282 title "How regularities in stimulus series and in ISI affect on MMN in persons with intellectual disabilities" @default.
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- W2092683282 doi "https://doi.org/10.1016/s0531-5131(01)00820-2" @default.
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