FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092686475> ?p ?o ?g. }

• W2092686475 endingPage "2097" @default.
• W2092686475 startingPage "2086" @default.
• W2092686475 abstract "The aim of this work was to optimize biodegradable polyester poly(glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL, microparticles as sustained release (SR) carriers for pulmonary drug delivery. Microparticles were produced by spray drying directly from double emulsion with and without dispersibility enhancers (L-arginine and L-leucine) (0.5–1.5%w/w) using sodium fluorescein (SF) as a model hydrophilic drug. Spray-dried microparticles without dispersibility enhancers exhibited aggregated powders leading to low fine particle fraction (%FPF) (28.79 ± 3.24), fine particle dose (FPD) (14.42 ± 1.57 μg), with a mass median aerodynamic diameter (MMAD) 2.86 ± 0.24 μm. However, L-leucine was significantly superior in enhancing the aerosolization performance (L-arginine:%FPF 27.61 ± 4.49–26.57 ± 1.85; FPD 12.40 ± 0.99–19.54 ± 0.16 μg and MMAD 2.18 ± 0.35–2.98 ± 0.25 μm, L-leucine:%FPF 36.90 ± 3.6–43.38 ± 5.6; FPD 18.66 ± 2.90–21.58 ± 2.46 μg and MMAD 2.55 ± 0.03–3.68 ± 0.12 μm). Incorporating L-leucine (1.5%w/w) reduced the burst release (24.04 ± 3.87%) of SF compared to unmodified formulations (41.87 ± 2.46%), with both undergoing a square root of time (Higuchi’s pattern) dependent release. Comparing the toxicity profiles of PGA-co-PDL with L-leucine (1.5%w/w) (5 mg/ml) and poly(lactide-co-glycolide), (5 mg/ml) spray-dried microparticles in human bronchial epithelial 16HBE14o- cell lines, resulted in cell viability of 85.57 ± 5.44 and 60.66 ± 6.75%, respectively, after 72 h treatment. The above data suggest that PGA-co-PDL may be a useful polymer for preparing SR microparticle carriers, together with dispersibility enhancers, for pulmonary delivery." @default.
• W2092686475 created "2016-06-24" @default.
• W2092686475 creator A5022107797 @default.
• W2092686475 creator A5022741655 @default.
• W2092686475 creator A5031252332 @default.
• W2092686475 creator A5031406536 @default.
• W2092686475 creator A5052107460 @default.
• W2092686475 creator A5058060165 @default.
• W2092686475 creator A5063188130 @default.
• W2092686475 creator A5065633820 @default.
• W2092686475 creator A5076152673 @default.
• W2092686475 date "2011-05-02" @default.
• W2092686475 modified "2023-10-17" @default.
• W2092686475 title "Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery" @default.
• W2092686475 cites W1547433582 @default.
• W2092686475 cites W1558228970 @default.
• W2092686475 cites W1977030791 @default.
• W2092686475 cites W1978500599 @default.
• W2092686475 cites W1980803266 @default.
• W2092686475 cites W1981881574 @default.
• W2092686475 cites W1985484350 @default.
• W2092686475 cites W1990620515 @default.
• W2092686475 cites W1993019338 @default.
• W2092686475 cites W2003132032 @default.
• W2092686475 cites W2005206177 @default.
• W2092686475 cites W2005639247 @default.
• W2092686475 cites W2014580315 @default.
• W2092686475 cites W2016093208 @default.
• W2092686475 cites W2017961570 @default.
• W2092686475 cites W2020818869 @default.
• W2092686475 cites W2021054017 @default.
• W2092686475 cites W2026576953 @default.
• W2092686475 cites W2032072745 @default.
• W2092686475 cites W2037480503 @default.
• W2092686475 cites W2037842504 @default.
• W2092686475 cites W2041919596 @default.
• W2092686475 cites W2046272055 @default.
• W2092686475 cites W2047824475 @default.
• W2092686475 cites W2053429494 @default.
• W2092686475 cites W2054334269 @default.
• W2092686475 cites W2063493825 @default.
• W2092686475 cites W2063797958 @default.
• W2092686475 cites W2069715353 @default.
• W2092686475 cites W2079082548 @default.
• W2092686475 cites W2082580562 @default.
• W2092686475 cites W2084935838 @default.
• W2092686475 cites W2089129742 @default.
• W2092686475 cites W2091202618 @default.
• W2092686475 cites W2093099615 @default.
• W2092686475 cites W2093976373 @default.
• W2092686475 cites W2095064415 @default.
• W2092686475 cites W2110791850 @default.
• W2092686475 cites W2112099760 @default.
• W2092686475 cites W2119446934 @default.
• W2092686475 cites W3199261357 @default.
• W2092686475 cites W4248984260 @default.
• W2092686475 cites W46997909 @default.
• W2092686475 doi "https://doi.org/10.1007/s11095-011-0433-6" @default.
• W2092686475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21533998" @default.
• W2092686475 hasPublicationYear "2011" @default.
• W2092686475 type Work @default.
• W2092686475 sameAs 2092686475 @default.
• W2092686475 citedByCount "40" @default.
• W2092686475 countsByYear W20926864752013 @default.
• W2092686475 countsByYear W20926864752014 @default.
• W2092686475 countsByYear W20926864752015 @default.
• W2092686475 countsByYear W20926864752016 @default.
• W2092686475 countsByYear W20926864752017 @default.
• W2092686475 countsByYear W20926864752018 @default.
• W2092686475 countsByYear W20926864752019 @default.
• W2092686475 countsByYear W20926864752020 @default.
• W2092686475 countsByYear W20926864752021 @default.
• W2092686475 countsByYear W20926864752022 @default.
• W2092686475 countsByYear W20926864752023 @default.
• W2092686475 crossrefType "journal-article" @default.
• W2092686475 hasAuthorship W2092686475A5022107797 @default.
• W2092686475 hasAuthorship W2092686475A5022741655 @default.
• W2092686475 hasAuthorship W2092686475A5031252332 @default.
• W2092686475 hasAuthorship W2092686475A5031406536 @default.
• W2092686475 hasAuthorship W2092686475A5052107460 @default.
• W2092686475 hasAuthorship W2092686475A5058060165 @default.
• W2092686475 hasAuthorship W2092686475A5063188130 @default.
• W2092686475 hasAuthorship W2092686475A5065633820 @default.
• W2092686475 hasAuthorship W2092686475A5076152673 @default.
• W2092686475 hasBestOaLocation W20926864752 @default.
• W2092686475 hasConcept C105702510 @default.
• W2092686475 hasConcept C127413603 @default.
• W2092686475 hasConcept C13245373 @default.
• W2092686475 hasConcept C13965031 @default.
• W2092686475 hasConcept C147789679 @default.
• W2092686475 hasConcept C178790620 @default.
• W2092686475 hasConcept C185592680 @default.
• W2092686475 hasConcept C187530423 @default.
• W2092686475 hasConcept C188027245 @default.
• W2092686475 hasConcept C202751555 @default.
• W2092686475 hasConcept C2776954882 @default.
• W2092686475 hasConcept C2777075361 @default.
• W2092686475 hasConcept C2777521759 @default.

• next