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• W2092698497 abstract "The spectrum of human thyroid cancer includes both indolent differentiated neoplasms and highly virulent, rapidly fatal anaplastic carcinoma. The majority of thyroid carcinomas (about 85%) fall into the differentiated end of this spectrum, are derived from follicular epithelium, are relatively easily treated, and are often cured. Anaplastic carcinomas are rapidly growing, widely infiltrative neoplasms, which, histologically, show marked pleomorphism. Despite aggressive therapy, fewer than 5% of affected patients survive 1 year. This spectrum is, in fact, a continuum, since tumours of intermediate clinical behaviour have been recognized. These lesions include aggressive variants of papillary carcinoma, and insular carcinoma. Tumours in these categories are associated with significant mortality (25%-90%) but multiyear survival rates can be achieved by therapies aimed at control of local recurrence and/or radioisotopic treatment of metastases. (This paper discusses only follicular derived lesions, not those related to C cells, i.e. medullary carcinoma and variants.) Does this continuum of malignancy foreshadow a grading system for neoplasms of follicular epithelial origin? Since the histological spectrum involves recognition of patterns rather than assessment of how closely the tumour simulates normal thyroid, this is not a grading system in the commonly used sense. However, as Sakamoto et al. [1] have postulated, division of these tumours into well differentiated, poorly differentiated, and undifferentiated lesions may be clinically relevant. These authors have suggested that the well differentiated group should include the usual papillary thyroid carcinoma (PTC) and true follicular carcinoma, and that insular, tall cell and columnar cell papillary carcinomas should be classified as poorly differentiated. Although not universally accepted, it is at least an approach similar to grading systems for malignancies of other organs, which may eventually become practical. However, until that time, it is suggested that the schema currently in use of descriptive diagnoses in thyroid tumours should be maintained with the understand-" @default.
• W2092698497 created "2016-06-24" @default.
• W2092698497 creator A5018580882 @default.
• W2092698497 date "1996-01-01" @default.
• W2092698497 modified "2023-09-25" @default.
• W2092698497 title "Well differentiated thyroid carcinoma" @default.
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• W2092698497 doi "https://doi.org/10.1016/s0936-6555(05)80712-5" @default.
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