FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092701497> ?p ?o ?g. }

• W2092701497 endingPage "1893" @default.
• W2092701497 startingPage "1887" @default.
• W2092701497 abstract "1 Effects of arachidonic acid (AA) on voltage-dependent Ca channel currents were investigated by whole-cell-clamp methods in single smooth muscle cells freshly isolated from vas deferens of the guinea-pig 2 Ca channel current was decreased by application of 1–30 μm AA in a concentration-dependent manner. When Ca2+ or Ba2+ was the charge carrier, Ca channel current (ICa or IBa) was reduced by AA to a similar extent (IC50= 10 and 6 μm, respectively). Addition of 15 mM BAPTA to the pipette solution did not affect the reduction of IBa by 10 μm AA 3 The effect of AA on IBa was not prevented by internal application of 1 mM nordihydroguaiaretic acid (NDGA) and 1 mM indomethacin (Indo). When the pipette solution contained 0.1 mM guanosine-5′-triphosphate (GTP), IBa was decreased slightly but significantly by application of 30 (M prostaglandin (PGF2α) but not by PGE2. This effect of PGF2α was irreversible or not observed when the pipette solution contained 0.3 mM guanosine-5′-(3-thiotriphosphate) (GTPγS) or both GTP or guanosine-5′-0-(2-thiodiphosphate) (GDPβS), respectively 4 External application of 100 units ml−1 superoxide dismutase slightly but significantly attenuated the inhibition of IBa by 1–30 μm AA. Intracellular application of 1 mM GDPβS or 0.3 mM GTPγS did not significantly change the effect of AA. Intracellular application of 0.1 mM 1-(5-isoquinolinesulphonyl)-2-methylepiperazine (H-7) also did not change the effect of AA 5 These results indicate that the decrease in Ca channel currents in vas deferens smooth muscle cells is mainly due to AA itself, as opposed to its metabolites. The effect of AA may be due to AA itself, as opposed to its metabolites. The effect of AA may be due to its direct action on Ca channels or membrane phospholipids, but may not be mediated by activation of GTP binding proteins or protein kinase C. The inhibition of Ca channel current by AA may be partly induced by superoxide radicals derived from AA oxidation. PGF2α also reduces Ca channel currents but probably by a separate mechanism via activation of a GTP binding protein." @default.
• W2092701497 created "2016-06-24" @default.
• W2092701497 creator A5002383599 @default.
• W2092701497 creator A5024030001 @default.
• W2092701497 date "1995-09-01" @default.
• W2092701497 modified "2023-10-04" @default.
• W2092701497 title "Modulation of calcium channel currents by arachidonic acid in single smooth muscle cells from vas deferens of the guinea-pig" @default.
• W2092701497 cites W1480719130 @default.
• W2092701497 cites W1517844096 @default.
• W2092701497 cites W1647996023 @default.
• W2092701497 cites W1899877571 @default.
• W2092701497 cites W1900262093 @default.
• W2092701497 cites W1923597418 @default.
• W2092701497 cites W1965721579 @default.
• W2092701497 cites W1972936763 @default.
• W2092701497 cites W1973454785 @default.
• W2092701497 cites W1991264393 @default.
• W2092701497 cites W1991825108 @default.
• W2092701497 cites W2005887351 @default.
• W2092701497 cites W2006202751 @default.
• W2092701497 cites W2006837023 @default.
• W2092701497 cites W2009667219 @default.
• W2092701497 cites W2011950546 @default.
• W2092701497 cites W2020857462 @default.
• W2092701497 cites W2026887642 @default.
• W2092701497 cites W2034368055 @default.
• W2092701497 cites W2036302562 @default.
• W2092701497 cites W2043528456 @default.
• W2092701497 cites W2053939695 @default.
• W2092701497 cites W2067598626 @default.
• W2092701497 cites W2074410830 @default.
• W2092701497 cites W2080875376 @default.
• W2092701497 cites W2083531507 @default.
• W2092701497 cites W2089992191 @default.
• W2092701497 cites W2121352744 @default.
• W2092701497 cites W2125753558 @default.
• W2092701497 cites W2134806942 @default.
• W2092701497 cites W2162152935 @default.
• W2092701497 cites W2165191737 @default.
• W2092701497 cites W2169209842 @default.
• W2092701497 cites W2396361843 @default.
• W2092701497 cites W2413032684 @default.
• W2092701497 cites W2414104084 @default.
• W2092701497 cites W2418364653 @default.
• W2092701497 cites W2470394169 @default.
• W2092701497 cites W47146608 @default.
• W2092701497 doi "https://doi.org/10.1111/j.1476-5381.1995.tb16678.x" @default.
• W2092701497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1909104" @default.
• W2092701497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8528575" @default.
• W2092701497 hasPublicationYear "1995" @default.
• W2092701497 type Work @default.
• W2092701497 sameAs 2092701497 @default.
• W2092701497 citedByCount "21" @default.
• W2092701497 countsByYear W20927014972012 @default.
• W2092701497 countsByYear W20927014972014 @default.
• W2092701497 countsByYear W20927014972017 @default.
• W2092701497 crossrefType "journal-article" @default.
• W2092701497 hasAuthorship W2092701497A5002383599 @default.
• W2092701497 hasAuthorship W2092701497A5024030001 @default.
• W2092701497 hasBestOaLocation W20927014971 @default.
• W2092701497 hasConcept C118716 @default.
• W2092701497 hasConcept C12554922 @default.
• W2092701497 hasConcept C126322002 @default.
• W2092701497 hasConcept C134018914 @default.
• W2092701497 hasConcept C147789679 @default.
• W2092701497 hasConcept C147944092 @default.
• W2092701497 hasConcept C151552171 @default.
• W2092701497 hasConcept C170493617 @default.
• W2092701497 hasConcept C181199279 @default.
• W2092701497 hasConcept C185592680 @default.
• W2092701497 hasConcept C2777995097 @default.
• W2092701497 hasConcept C2778078955 @default.
• W2092701497 hasConcept C2778210472 @default.
• W2092701497 hasConcept C2780019300 @default.
• W2092701497 hasConcept C55493867 @default.
• W2092701497 hasConcept C71924100 @default.
• W2092701497 hasConcept C79879829 @default.
• W2092701497 hasConcept C86803240 @default.
• W2092701497 hasConceptScore W2092701497C118716 @default.
• W2092701497 hasConceptScore W2092701497C12554922 @default.
• W2092701497 hasConceptScore W2092701497C126322002 @default.
• W2092701497 hasConceptScore W2092701497C134018914 @default.
• W2092701497 hasConceptScore W2092701497C147789679 @default.
• W2092701497 hasConceptScore W2092701497C147944092 @default.
• W2092701497 hasConceptScore W2092701497C151552171 @default.
• W2092701497 hasConceptScore W2092701497C170493617 @default.
• W2092701497 hasConceptScore W2092701497C181199279 @default.
• W2092701497 hasConceptScore W2092701497C185592680 @default.
• W2092701497 hasConceptScore W2092701497C2777995097 @default.
• W2092701497 hasConceptScore W2092701497C2778078955 @default.
• W2092701497 hasConceptScore W2092701497C2778210472 @default.
• W2092701497 hasConceptScore W2092701497C2780019300 @default.
• W2092701497 hasConceptScore W2092701497C55493867 @default.
• W2092701497 hasConceptScore W2092701497C71924100 @default.
• W2092701497 hasConceptScore W2092701497C79879829 @default.
• W2092701497 hasConceptScore W2092701497C86803240 @default.
• W2092701497 hasIssue "2" @default.
• W2092701497 hasLocation W20927014971 @default.

• next