Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092706820> ?p ?o ?g. }
- W2092706820 endingPage "1074" @default.
- W2092706820 startingPage "1067" @default.
- W2092706820 abstract "The development of donor-specific anti-human leukocyte antigen antibodies (DSAs) following renal transplantation significantly reduces long-term renal graft function and survival. The traditional therapies for antibody-mediated rejection (AMR) have provided inconsistent results and transient effects that may be due to a failure to deplete mature antibody-producing plasma cells. Proteasome inhibition (PI) is a novel AMR therapy that deletes plasma cells. Initial reports of PI-based AMR treatment in refractory rejection demonstrated the ability of bortezomib to deplete plasma cells producing DSA, reduce DSA levels, provide histological improvement or resolution, and improve renal allograft function. These results have subsequently been confirmed in a multicenter collaborative study. PI has also been shown to provide effective primary AMR therapy in case reports. Recent studies have demonstrated that PI therapy results in differential responses in early and late post-transplant AMR. Additional randomized studies are evaluating the role of PI in transplant induction, acute AMR, and chronic rejection in renal transplantation. An important theoretical advantage of PI-based regimens is derived from several potential strategies for achievement of synergy." @default.
- W2092706820 created "2016-06-24" @default.
- W2092706820 creator A5006876478 @default.
- W2092706820 creator A5021985846 @default.
- W2092706820 creator A5027751857 @default.
- W2092706820 creator A5058858595 @default.
- W2092706820 date "2012-06-01" @default.
- W2092706820 modified "2023-10-16" @default.
- W2092706820 title "Proteasome inhibitor-based therapy for antibody-mediated rejection" @default.
- W2092706820 cites W1506252195 @default.
- W2092706820 cites W1526931462 @default.
- W2092706820 cites W1966348678 @default.
- W2092706820 cites W1972168830 @default.
- W2092706820 cites W1972879732 @default.
- W2092706820 cites W1977270201 @default.
- W2092706820 cites W1978188507 @default.
- W2092706820 cites W1979090219 @default.
- W2092706820 cites W1983537514 @default.
- W2092706820 cites W1986678613 @default.
- W2092706820 cites W1989518522 @default.
- W2092706820 cites W1989569525 @default.
- W2092706820 cites W1994085514 @default.
- W2092706820 cites W1995805772 @default.
- W2092706820 cites W1996635899 @default.
- W2092706820 cites W2010019720 @default.
- W2092706820 cites W2016066312 @default.
- W2092706820 cites W2024855035 @default.
- W2092706820 cites W2026043555 @default.
- W2092706820 cites W2026642838 @default.
- W2092706820 cites W2029758461 @default.
- W2092706820 cites W2029956572 @default.
- W2092706820 cites W2031809342 @default.
- W2092706820 cites W2047650149 @default.
- W2092706820 cites W2049435289 @default.
- W2092706820 cites W2057628172 @default.
- W2092706820 cites W2059446551 @default.
- W2092706820 cites W2060631974 @default.
- W2092706820 cites W2071708791 @default.
- W2092706820 cites W2074051660 @default.
- W2092706820 cites W2091378741 @default.
- W2092706820 cites W2091403769 @default.
- W2092706820 cites W2093967500 @default.
- W2092706820 cites W2103185055 @default.
- W2092706820 cites W2104599023 @default.
- W2092706820 cites W2164710551 @default.
- W2092706820 cites W2330597417 @default.
- W2092706820 cites W2356498392 @default.
- W2092706820 doi "https://doi.org/10.1038/ki.2011.502" @default.
- W2092706820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22336990" @default.
- W2092706820 hasPublicationYear "2012" @default.
- W2092706820 type Work @default.
- W2092706820 sameAs 2092706820 @default.
- W2092706820 citedByCount "89" @default.
- W2092706820 countsByYear W20927068202012 @default.
- W2092706820 countsByYear W20927068202013 @default.
- W2092706820 countsByYear W20927068202014 @default.
- W2092706820 countsByYear W20927068202015 @default.
- W2092706820 countsByYear W20927068202016 @default.
- W2092706820 countsByYear W20927068202017 @default.
- W2092706820 countsByYear W20927068202018 @default.
- W2092706820 countsByYear W20927068202019 @default.
- W2092706820 countsByYear W20927068202020 @default.
- W2092706820 countsByYear W20927068202021 @default.
- W2092706820 countsByYear W20927068202022 @default.
- W2092706820 countsByYear W20927068202023 @default.
- W2092706820 crossrefType "journal-article" @default.
- W2092706820 hasAuthorship W2092706820A5006876478 @default.
- W2092706820 hasAuthorship W2092706820A5021985846 @default.
- W2092706820 hasAuthorship W2092706820A5027751857 @default.
- W2092706820 hasAuthorship W2092706820A5058858595 @default.
- W2092706820 hasBestOaLocation W20927068201 @default.
- W2092706820 hasConcept C126322002 @default.
- W2092706820 hasConcept C159641895 @default.
- W2092706820 hasConcept C159654299 @default.
- W2092706820 hasConcept C203014093 @default.
- W2092706820 hasConcept C2776364478 @default.
- W2092706820 hasConcept C2776396001 @default.
- W2092706820 hasConcept C2777478702 @default.
- W2092706820 hasConcept C2778367456 @default.
- W2092706820 hasConcept C2780303639 @default.
- W2092706820 hasConcept C2911091166 @default.
- W2092706820 hasConcept C542903549 @default.
- W2092706820 hasConcept C71924100 @default.
- W2092706820 hasConceptScore W2092706820C126322002 @default.
- W2092706820 hasConceptScore W2092706820C159641895 @default.
- W2092706820 hasConceptScore W2092706820C159654299 @default.
- W2092706820 hasConceptScore W2092706820C203014093 @default.
- W2092706820 hasConceptScore W2092706820C2776364478 @default.
- W2092706820 hasConceptScore W2092706820C2776396001 @default.
- W2092706820 hasConceptScore W2092706820C2777478702 @default.
- W2092706820 hasConceptScore W2092706820C2778367456 @default.
- W2092706820 hasConceptScore W2092706820C2780303639 @default.
- W2092706820 hasConceptScore W2092706820C2911091166 @default.
- W2092706820 hasConceptScore W2092706820C542903549 @default.
- W2092706820 hasConceptScore W2092706820C71924100 @default.
- W2092706820 hasIssue "11" @default.
- W2092706820 hasLocation W20927068201 @default.
- W2092706820 hasLocation W20927068202 @default.