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• W2092712137 abstract "This study examined the development of the gonadotropin releasing-hormone (GnRH) system in a spontaneous mouse mutation, Small-Eye (Sey). This phenotype is due to a point mutation in the developmental control gene Pax-6 and results in failed development of the eye and olfactory placodes in homozygous (Sey/Sey) embryos and a variety of eye abnormalities in heterozygotes (Sey/+). Therefore, Sey/Sey embryos provided a naturally occurring olfactory placode ablation to ask whether all of the GnRH neurons found in the adult mouse forebrain arise from the olfactory epithelium. In Sey/Sey embryos, GnRH-immunoreactive neurons were not present in either the presumptive nasal regions or in any area of the brain at any embryonic age. In contrast, in Sey/+ embryos, there was no apparent effect on either GnRH cell proliferation or migration. These data support and extend the hypothesis that GnRH neurons in mice originate in the olfactory placodes and also demonstrate that two normal alleles of Pax-6 are not required for GnRH system development." @default.
• W2092712137 created "2016-06-24" @default.
• W2092712137 creator A5033985814 @default.
• W2092712137 creator A5034101983 @default.
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• W2092712137 date "1998-05-01" @default.
• W2092712137 modified "2023-09-23" @default.
• W2092712137 title "The gonadotropin-releasing hormone system does not develop in small-eye (Sey) mouse phenotype" @default.
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• W2092712137 doi "https://doi.org/10.1016/s0165-3806(98)00007-8" @default.
• W2092712137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9593910" @default.
• W2092712137 hasPublicationYear "1998" @default.
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