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- W2092721169 abstract "To evaluate the benefits and risks of pitolisant (a wake-enhancing drug that increases the histamine release in the brain by blocking presynaptic H3 histamine reuptake) in patients with idiopathic (IH) and symptomatic (SH) hypersomnia plus sleepiness refractory to available stimulants (modafinil, methylphenidate, mazindol, sodium oxybate, and d-amphetamine). Through retrospective analyses of patient files, the benefit (the score from the Epworth Sleepiness Scale [ESS], authorization renewal) and tolerance (side-effects) of pitolisant were assessed. A total of 78 patients with IH (n = 65%, 78% women) and SH (n = 13%, 54% women) received pitolisant 5–50 mg once per day over the course of five days to 37 months. The median (interquartile range) ESS scores of patients with IH decreased from 17 (15.5–18.5) to 14 (12–17). There were 36% responders (ESS fall of ⩾3). The improvement in ESS score (−1.9 ± 2.6) was different from 0 in IH without long sleep time (P < 0.002) and in IH with a long sleep time (P < 0.0001), but not in SH. Forty-four (63%) patients with IH and 12 (77%) patients with SH stopped pitolisant, mostly due to a lack of efficacy. Side-effects included gastrointestinal pain (15.4%), increased appetite and weight gain (14.1%), headache (12.8%), insomnia (11.5%), and anxiety (9%), as well as exceptional reports of depression and persistent genital arousal. Pitolisant had a long-term favorable benefit/risk ratio in 23–38% of drug-resistant patients with IH and SH, suggesting that histamine neurons can be stimulated in severe idiopathic and symptomatic hypersomnia." @default.
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- W2092721169 date "2014-06-01" @default.
- W2092721169 modified "2023-10-16" @default.
- W2092721169 title "Effects of pitolisant, a histamine H3 inverse agonist, in drug-resistant idiopathic and symptomatic hypersomnia: a chart review" @default.
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- W2092721169 doi "https://doi.org/10.1016/j.sleep.2014.01.021" @default.
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