FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092724693> ?p ?o ?g. }

• W2092724693 endingPage "1188" @default.
• W2092724693 startingPage "1179" @default.
• W2092724693 abstract "Hexachlorobenzene-induced porphyria is iron dependent and characterized by the decreased activity of uroporphyrinogen decarboxylase and the accumulation of porphyrins in the liver. To examine the relationship between iron and porphyrins in liver tissue, we performed a biochemical and morphological (histological, ultrastructural and morphometrical) study in the livers of C57BL/10 mice. Mice were treated with hexachlorobenzene, iron dextran or the combination of hexachlorobenzene and iron dextran. An accumulation of porphyrins and an increased total iron content were found not only in the livers of mice treated with hexachlorobenzene and iron dextran but also in mice treated with iron dextran alone. In contrast, the amount of porphyrins was only slightly increased in the livers of mice treated with hexachlorobenzene alone. Needle-like structures, representing uroporphyrin crystals, were observed, histologically and ultrastructurally, in hepatocytes of mice treated with hexachlorobenzene and iron dextran and with iron dextran alone. Uroporphyrin crystals and ferritin iron were found in the same hepatocyte. A single uroporphyrin crystal, surrounded by ferritin iron, was observed in a hepatocyte of a mouse treated with hexachlorobenzene alone. Both in the livers of mice treated with hexachlorobenzene and iron dextran and in the livers of mice treated with iron dextran alone, morphometrical analysis showed that an increased area fraction of uroporphyrin crystals was associated with an increased area fraction of ferritin iron in hepatocytes.In C57BL/10 mice, experimental porphyria can be induced by iron overload alone; uroporphyrin crystals and ferritin iron are located in the same hepatocyte; and the morphological co-occurrence of uroporphyrin crystals and ferritin iron in hepatocytes suggests a role for iron (as ferritin) in the pathogenesis of porphyria." @default.
• W2092724693 created "2016-06-24" @default.
• W2092724693 creator A5009049345 @default.
• W2092724693 creator A5026525883 @default.
• W2092724693 creator A5033897264 @default.
• W2092724693 creator A5038869918 @default.
• W2092724693 creator A5074268246 @default.
• W2092724693 creator A5084059327 @default.
• W2092724693 creator A5086249090 @default.
• W2092724693 date "1991-12-01" @default.
• W2092724693 modified "2023-09-27" @default.
• W2092724693 title "Iron and uroporphyrin in hepatocytes of inbred mice in experimental porphyria: A biochemical and morphological study" @default.
• W2092724693 cites W1269501328 @default.
• W2092724693 cites W1488199919 @default.
• W2092724693 cites W1499955189 @default.
• W2092724693 cites W150316883 @default.
• W2092724693 cites W157133164 @default.
• W2092724693 cites W1775749144 @default.
• W2092724693 cites W1792712697 @default.
• W2092724693 cites W1858015527 @default.
• W2092724693 cites W193854866 @default.
• W2092724693 cites W1943047487 @default.
• W2092724693 cites W1964192331 @default.
• W2092724693 cites W1964566320 @default.
• W2092724693 cites W1965042318 @default.
• W2092724693 cites W1965323201 @default.
• W2092724693 cites W1976097382 @default.
• W2092724693 cites W1977538957 @default.
• W2092724693 cites W1977770183 @default.
• W2092724693 cites W1984046403 @default.
• W2092724693 cites W1996334556 @default.
• W2092724693 cites W2003349488 @default.
• W2092724693 cites W2004637274 @default.
• W2092724693 cites W2008502630 @default.
• W2092724693 cites W2015740390 @default.
• W2092724693 cites W2022332390 @default.
• W2092724693 cites W2037729805 @default.
• W2092724693 cites W2049669196 @default.
• W2092724693 cites W2055577421 @default.
• W2092724693 cites W2063373861 @default.
• W2092724693 cites W2067539215 @default.
• W2092724693 cites W2067887201 @default.
• W2092724693 cites W2069471046 @default.
• W2092724693 cites W2072775166 @default.
• W2092724693 cites W2075363291 @default.
• W2092724693 cites W2081912110 @default.
• W2092724693 cites W2083880470 @default.
• W2092724693 cites W2084257956 @default.
• W2092724693 cites W2089288530 @default.
• W2092724693 cites W2095450966 @default.
• W2092724693 cites W2103634702 @default.
• W2092724693 cites W2106909413 @default.
• W2092724693 cites W2144528537 @default.
• W2092724693 cites W2161198676 @default.
• W2092724693 cites W2212694267 @default.
• W2092724693 cites W2218041908 @default.
• W2092724693 cites W2224715033 @default.
• W2092724693 cites W2316042352 @default.
• W2092724693 cites W2403191036 @default.
• W2092724693 cites W2469799128 @default.
• W2092724693 cites W2894646342 @default.
• W2092724693 cites W94896511 @default.
• W2092724693 doi "https://doi.org/10.1002/hep.1840140637" @default.
• W2092724693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1959868" @default.
• W2092724693 hasPublicationYear "1991" @default.
• W2092724693 type Work @default.
• W2092724693 sameAs 2092724693 @default.
• W2092724693 citedByCount "17" @default.
• W2092724693 countsByYear W20927246932012 @default.
• W2092724693 countsByYear W20927246932018 @default.
• W2092724693 countsByYear W20927246932020 @default.
• W2092724693 crossrefType "journal-article" @default.
• W2092724693 hasAuthorship W2092724693A5009049345 @default.
• W2092724693 hasAuthorship W2092724693A5026525883 @default.
• W2092724693 hasAuthorship W2092724693A5033897264 @default.
• W2092724693 hasAuthorship W2092724693A5038869918 @default.
• W2092724693 hasAuthorship W2092724693A5074268246 @default.
• W2092724693 hasAuthorship W2092724693A5084059327 @default.
• W2092724693 hasAuthorship W2092724693A5086249090 @default.
• W2092724693 hasConcept C126322002 @default.
• W2092724693 hasConcept C134018914 @default.
• W2092724693 hasConcept C153911025 @default.
• W2092724693 hasConcept C172110603 @default.
• W2092724693 hasConcept C178790620 @default.
• W2092724693 hasConcept C181199279 @default.
• W2092724693 hasConcept C185592680 @default.
• W2092724693 hasConcept C202751555 @default.
• W2092724693 hasConcept C2776200302 @default.
• W2092724693 hasConcept C2776217839 @default.
• W2092724693 hasConcept C2777339698 @default.
• W2092724693 hasConcept C2777940757 @default.
• W2092724693 hasConcept C2778319317 @default.
• W2092724693 hasConcept C2779423988 @default.
• W2092724693 hasConcept C55493867 @default.
• W2092724693 hasConcept C71924100 @default.
• W2092724693 hasConcept C82685317 @default.
• W2092724693 hasConcept C86803240 @default.
• W2092724693 hasConceptScore W2092724693C126322002 @default.

• next