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• W2092746483 abstract "We used a primate model of male-pattern baldness to test the efficacy of a topically applied 5 alpha-reductase inhibitor and antiandrogen (4-MA) in the prevention of baldness. Six periadolescent stumptail macaques were given daily topical applications of either 4-MA in dimethylsulfoxide or dimethylsulfoxide alone for 27 months. The three control monkeys developed varying degrees of baldness, while the three 4-MA-treated monkeys retained their juvenile pattern of hair growth. The percentage of actively growing hair follicles in the frontal scalp did not change in the 4-MA-treated group [46 +/- 6 (+/- SE) vs. 48 +/- 4], while a significant decrease occurred in the control group (63 +/- 6 vs. 25 +/- 12; P less than 0.025). Skin 5 alpha-reductase activity was reduced in the scalp of the 4-MA-treated monkeys. We conclude that topical 4-MA can prevent the development of baldness in the stumptail macaque, a primate model of androgen-dependent baldness." @default.
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• W2092746483 date "1987-07-01" @default.
• W2092746483 modified "2023-10-18" @default.
• W2092746483 title "The Effects of<i>N,N</i>-Diethyl-4-Methyl-3-Oxo-4-Aza-5<i>α</i>-Androstane-17<i>yβ</i>-Carboxamide, a 5<i>α</i>-Reductase Inhibitor and Antiandrogen, on the Development of Baldness in the Stumptail Macaque*" @default.
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• W2092746483 doi "https://doi.org/10.1210/jcem-65-1-188" @default.
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