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- W2092762976 abstract "There is no doubt that ultraviolet radiation (UVR) contributes to the generation of acquired lentigines in human skin, as indicated by the term solar lentigo. A growing number of recent epidemiological and mechanistic studies, however, strongly suggest that in addition to UVR, other environmental factors contribute to lentigines' formation as well. We therefore here introduce the term 'environment-induced lentigo' (EIL) to refer to acquired pigment spots of human skin. In this view point, we (i) summarize the existing evidence to support a role of environmental toxicants other than UVR in the pathogenesis of EILs, (ii) we argue that activation of aryl hydrocarbon receptor (AHR) signalling by UVR and environmental toxicants is critically involved in triggering and sustaining a crosstalk between melanocytes, keratinocytes and fibroblasts, which then causes the development and persistence of EILs in human skin, and (iii) we discuss clinical implications for the prevention and treatment of EILs resulting from this concept." @default.
- W2092762976 created "2016-06-24" @default.
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- W2092762976 date "2015-04-16" @default.
- W2092762976 modified "2023-10-18" @default.
- W2092762976 title "Environment‐induced lentigines: formation of solar lentigines beyond ultraviolet radiation" @default.
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- W2092762976 doi "https://doi.org/10.1111/exd.12690" @default.
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