FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092764550> ?p ?o ?g. }

• W2092764550 endingPage "79" @default.
• W2092764550 startingPage "71" @default.
• W2092764550 abstract "Background Experimental data accumulated over more than a decade indicate that cross‐strain protection against influenza may be achieved by immunization with conserved influenza proteins. At the same time, the efficacy of immunization schemes designed along these lines and involving internal influenza proteins, mostly NP and M1, has not been sufficient. Objective To test the immunogenicity and protective efficacy of DNA vaccination with a combination of NP, M1 and NS1 genes of influenza virus. Methods The immunogenicity and protective efficacy of DNA vaccination with NP, M1 and NS1 was tested in mice and chickens. Mice were challenged with mouse‐adapted viral strains H3N2 and H5N2 and chicken challenged with avian H5N3 virus. Results In these settings, wild‐type NS1 did not impede the cellular and humoral response to NP/M1 immunization in vivo . Moreover, addition of NS1‐encoding plasmid to the NP/M1 immunization protocol resulted in a significantly increased protective efficacy in vivo . Conclusions The addition of NS1 to an influenza immunization regimen based on conserved proteins bears promise. It is feasible that upon further genetic modification of these and additional conserved influenza proteins, providing for their higher safety, expression and immunogenicity, a recombinant vaccine based on several structural and non‐structural proteins or their epitopes will offer broad anti‐influenza protection in a wide range of species." @default.
• W2092764550 created "2016-06-24" @default.
• W2092764550 creator A5003806307 @default.
• W2092764550 creator A5013751157 @default.
• W2092764550 creator A5032252999 @default.
• W2092764550 creator A5035887406 @default.
• W2092764550 creator A5038630984 @default.
• W2092764550 creator A5048159214 @default.
• W2092764550 creator A5049616788 @default.
• W2092764550 creator A5050342101 @default.
• W2092764550 creator A5060131875 @default.
• W2092764550 creator A5075511489 @default.
• W2092764550 date "2007-03-01" @default.
• W2092764550 modified "2023-10-12" @default.
• W2092764550 title "Protection against mouse and avian influenza A strains via vaccination with a combination of conserved proteins NP, M1 and NS1" @default.
• W2092764550 cites W1721077015 @default.
• W2092764550 cites W1904826643 @default.
• W2092764550 cites W1972273444 @default.
• W2092764550 cites W1993666065 @default.
• W2092764550 cites W1993752607 @default.
• W2092764550 cites W1997173625 @default.
• W2092764550 cites W2001953488 @default.
• W2092764550 cites W2002429449 @default.
• W2092764550 cites W2011203815 @default.
• W2092764550 cites W2012362209 @default.
• W2092764550 cites W2016087169 @default.
• W2092764550 cites W2017309788 @default.
• W2092764550 cites W2017484306 @default.
• W2092764550 cites W2028920978 @default.
• W2092764550 cites W2029566681 @default.
• W2092764550 cites W2037164614 @default.
• W2092764550 cites W2039848934 @default.
• W2092764550 cites W2048162805 @default.
• W2092764550 cites W2077332396 @default.
• W2092764550 cites W2082893165 @default.
• W2092764550 cites W2086163123 @default.
• W2092764550 cites W2101954404 @default.
• W2092764550 cites W2101970047 @default.
• W2092764550 cites W2102750406 @default.
• W2092764550 cites W2126281540 @default.
• W2092764550 cites W2131381089 @default.
• W2092764550 cites W2136916525 @default.
• W2092764550 cites W2137953161 @default.
• W2092764550 cites W2164759261 @default.
• W2092764550 cites W2169905292 @default.
• W2092764550 cites W2170408138 @default.
• W2092764550 cites W2183872598 @default.
• W2092764550 cites W4233693336 @default.
• W2092764550 doi "https://doi.org/10.1111/j.1750-2659.2007.00010.x" @default.
• W2092764550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2040185" @default.
• W2092764550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18784792" @default.
• W2092764550 hasPublicationYear "2007" @default.
• W2092764550 type Work @default.
• W2092764550 sameAs 2092764550 @default.
• W2092764550 citedByCount "28" @default.
• W2092764550 countsByYear W20927645502012 @default.
• W2092764550 countsByYear W20927645502013 @default.
• W2092764550 countsByYear W20927645502014 @default.
• W2092764550 countsByYear W20927645502015 @default.
• W2092764550 countsByYear W20927645502016 @default.
• W2092764550 countsByYear W20927645502017 @default.
• W2092764550 crossrefType "journal-article" @default.
• W2092764550 hasAuthorship W2092764550A5003806307 @default.
• W2092764550 hasAuthorship W2092764550A5013751157 @default.
• W2092764550 hasAuthorship W2092764550A5032252999 @default.
• W2092764550 hasAuthorship W2092764550A5035887406 @default.
• W2092764550 hasAuthorship W2092764550A5038630984 @default.
• W2092764550 hasAuthorship W2092764550A5048159214 @default.
• W2092764550 hasAuthorship W2092764550A5049616788 @default.
• W2092764550 hasAuthorship W2092764550A5050342101 @default.
• W2092764550 hasAuthorship W2092764550A5060131875 @default.
• W2092764550 hasAuthorship W2092764550A5075511489 @default.
• W2092764550 hasBestOaLocation W20927645502 @default.
• W2092764550 hasConcept C104317684 @default.
• W2092764550 hasConcept C159047783 @default.
• W2092764550 hasConcept C159654299 @default.
• W2092764550 hasConcept C167508917 @default.
• W2092764550 hasConcept C195616568 @default.
• W2092764550 hasConcept C203014093 @default.
• W2092764550 hasConcept C22070199 @default.
• W2092764550 hasConcept C2522874641 @default.
• W2092764550 hasConcept C2777546802 @default.
• W2092764550 hasConcept C2780689484 @default.
• W2092764550 hasConcept C2780801004 @default.
• W2092764550 hasConcept C2780868878 @default.
• W2092764550 hasConcept C40767141 @default.
• W2092764550 hasConcept C519248777 @default.
• W2092764550 hasConcept C54355233 @default.
• W2092764550 hasConcept C7842527 @default.
• W2092764550 hasConcept C86803240 @default.
• W2092764550 hasConcept C8891405 @default.
• W2092764550 hasConcept C89423630 @default.
• W2092764550 hasConceptScore W2092764550C104317684 @default.
• W2092764550 hasConceptScore W2092764550C159047783 @default.
• W2092764550 hasConceptScore W2092764550C159654299 @default.
• W2092764550 hasConceptScore W2092764550C167508917 @default.
• W2092764550 hasConceptScore W2092764550C195616568 @default.
• W2092764550 hasConceptScore W2092764550C203014093 @default.

• next