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- W2092788851 endingPage "121" @default.
- W2092788851 startingPage "121" @default.
- W2092788851 abstract "The consequences of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) co-infection on progression of severe liver diseases is a serious public health issue, worldwide. In the co-infection cases, about 90% of HIV-infected population is seropositive for HBV where approximately 5%-40% individuals are chronically infected. In HIV co-infected individuals, liver-related mortality is estimated over 17 times higher than those with HBV mono-infection. The spectrum of HIV-induced liver diseases includes hepatitis, steatohepatitis, endothelialitis, necrosis, granulomatosis, cirrhosis and carcinoma. Moreover, HIV co-infection significantly alters the natural history of hepatitis B, and therefore complicates the disease management. Though several studies have demonstrated impact of HIV proteins on hepatocyte biology, only a few data is available on interactions between HBV and HIV proteins. Thus, the clinical spectrum as well as the complexity of the co-infection offers challenging fronts to study the underlying molecular mechanisms, and to design effective therapeutic strategies." @default.
- W2092788851 created "2016-06-24" @default.
- W2092788851 creator A5030443288 @default.
- W2092788851 date "2015-01-01" @default.
- W2092788851 modified "2023-09-27" @default.
- W2092788851 title "HBV and HIV co-infection: Impact on liver pathobiology and therapeutic approaches" @default.
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- W2092788851 doi "https://doi.org/10.4254/wjh.v7.i1.121" @default.
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