FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092789969> ?p ?o ?g. }

• W2092789969 endingPage "982" @default.
• W2092789969 startingPage "970" @default.
• W2092789969 abstract "7,12-Dimethylbenz(a)anthracene (DMBA) causes massive ACTH-dependent necrosis of the rat adrenal cortex. This may be related to an ACTH-inducible adrenal microsomal cytochrome P450 that metabolizes polycyclic aromatic hydrocarbons (PAH). The proportions of major monooxygenated products of rat adrenal microsomal DMBA metabolism (DMBA-8,9-diol, November DMBA-3,4-diol, and DMBA-phenols) differ significantly from that of P450IA1, the most active PAH-metabolizing P450 in rat liver microsomes. After hypophysectomy, both DMBA metabolic activity and a 57K protein which is distinct from P450XXI disappear from rat adrenal microsomes. ACTH restores both 57K protein and DMBA metabolic activity in hypophysectomized rats almost to the levels in intact untreated rats, but not to levels in ACTH-induced intact rats. The 57K protein has been partially purified from solubilized microsomes in a single step, using detergent elution from a new HPLC matrix consisting of monolayers of phosphatidylcholine covalently bound to a silica support. The resulting P450 preparation contains a single major (57K) band, constituting approximately 70% of the total protein (specific content, 2 nmol P450/ mg protein; turnover number, 1.5 nmol DMBA min−1). A rabbit polyclonal antibody raised against this preparation also recognizes a single ACTH-inducible 57K rat adrenal microsomal protein on immunoblots and dose-dependently inhibits DMBA metabolism in solubilized reconstituted rat adrenal microsomes. This 57K P450 is immunochemically distinct from rat P450s of the I, II, III, XVII, and XXI families, but it is immunochemically closely related to a 55K benz(a)anthracene-inducible P450 in the 10T1/2 mouse embryo fibroblast cell line." @default.
• W2092789969 created "2016-06-24" @default.
• W2092789969 creator A5002562057 @default.
• W2092789969 creator A5003497148 @default.
• W2092789969 creator A5009417920 @default.
• W2092789969 creator A5015071746 @default.
• W2092789969 date "1991-08-01" @default.
• W2092789969 modified "2023-09-24" @default.
• W2092789969 title "A Novel Adrenocorticotropin-Inducible Cytochrome P450 from Rat Adrenal Microsomes Catalyzes Polycylic Aromatic Hydrocarbon Metabolism*" @default.
• W2092789969 cites W1044270360 @default.
• W2092789969 cites W1529933235 @default.
• W2092789969 cites W1532212858 @default.
• W2092789969 cites W1563004338 @default.
• W2092789969 cites W1608262032 @default.
• W2092789969 cites W1841053541 @default.
• W2092789969 cites W1951469402 @default.
• W2092789969 cites W1967682161 @default.
• W2092789969 cites W1968954705 @default.
• W2092789969 cites W1972964661 @default.
• W2092789969 cites W1982300181 @default.
• W2092789969 cites W1985257301 @default.
• W2092789969 cites W1992057754 @default.
• W2092789969 cites W1999876886 @default.
• W2092789969 cites W2001351457 @default.
• W2092789969 cites W2005946349 @default.
• W2092789969 cites W2006088867 @default.
• W2092789969 cites W2006802875 @default.
• W2092789969 cites W2013658691 @default.
• W2092789969 cites W2017431020 @default.
• W2092789969 cites W2019715926 @default.
• W2092789969 cites W2024499940 @default.
• W2092789969 cites W2042631941 @default.
• W2092789969 cites W2046491869 @default.
• W2092789969 cites W2057332181 @default.
• W2092789969 cites W2060163537 @default.
• W2092789969 cites W2061352113 @default.
• W2092789969 cites W2062571588 @default.
• W2092789969 cites W2065036109 @default.
• W2092789969 cites W2072644588 @default.
• W2092789969 cites W2072898572 @default.
• W2092789969 cites W2076746680 @default.
• W2092789969 cites W2086306949 @default.
• W2092789969 cites W2095065893 @default.
• W2092789969 cites W2100837269 @default.
• W2092789969 cites W2101108802 @default.
• W2092789969 cites W2117816495 @default.
• W2092789969 cites W2146662639 @default.
• W2092789969 cites W2151802894 @default.
• W2092789969 cites W2168908700 @default.
• W2092789969 cites W2274594089 @default.
• W2092789969 cites W2431785334 @default.
• W2092789969 cites W2461366102 @default.
• W2092789969 cites W876372620 @default.
• W2092789969 cites W1579461087 @default.
• W2092789969 doi "https://doi.org/10.1210/endo-129-2-970" @default.
• W2092789969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1649753" @default.
• W2092789969 hasPublicationYear "1991" @default.
• W2092789969 type Work @default.
• W2092789969 sameAs 2092789969 @default.
• W2092789969 citedByCount "92" @default.
• W2092789969 countsByYear W20927899692013 @default.
• W2092789969 countsByYear W20927899692014 @default.
• W2092789969 countsByYear W20927899692015 @default.
• W2092789969 countsByYear W20927899692016 @default.
• W2092789969 countsByYear W20927899692017 @default.
• W2092789969 countsByYear W20927899692018 @default.
• W2092789969 countsByYear W20927899692019 @default.
• W2092789969 crossrefType "journal-article" @default.
• W2092789969 hasAuthorship W2092789969A5002562057 @default.
• W2092789969 hasAuthorship W2092789969A5003497148 @default.
• W2092789969 hasAuthorship W2092789969A5009417920 @default.
• W2092789969 hasAuthorship W2092789969A5015071746 @default.
• W2092789969 hasBestOaLocation W20927899691 @default.
• W2092789969 hasConcept C104317684 @default.
• W2092789969 hasConcept C126322002 @default.
• W2092789969 hasConcept C134018914 @default.
• W2092789969 hasConcept C181199279 @default.
• W2092789969 hasConcept C185592680 @default.
• W2092789969 hasConcept C2776260934 @default.
• W2092789969 hasConcept C2776719974 @default.
• W2092789969 hasConcept C2778938436 @default.
• W2092789969 hasConcept C526171541 @default.
• W2092789969 hasConcept C55493867 @default.
• W2092789969 hasConcept C555283112 @default.
• W2092789969 hasConcept C62231903 @default.
• W2092789969 hasConcept C71924100 @default.
• W2092789969 hasConcept C86803240 @default.
• W2092789969 hasConcept C87644729 @default.
• W2092789969 hasConceptScore W2092789969C104317684 @default.
• W2092789969 hasConceptScore W2092789969C126322002 @default.
• W2092789969 hasConceptScore W2092789969C134018914 @default.
• W2092789969 hasConceptScore W2092789969C181199279 @default.
• W2092789969 hasConceptScore W2092789969C185592680 @default.
• W2092789969 hasConceptScore W2092789969C2776260934 @default.
• W2092789969 hasConceptScore W2092789969C2776719974 @default.
• W2092789969 hasConceptScore W2092789969C2778938436 @default.
• W2092789969 hasConceptScore W2092789969C526171541 @default.
• W2092789969 hasConceptScore W2092789969C55493867 @default.

• next