Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092802479> ?p ?o ?g. }
- W2092802479 endingPage "640" @default.
- W2092802479 startingPage "627" @default.
- W2092802479 abstract "Recent brain imaging studies have indicated that schizophrenia is associated with increased amphetamine-induced dopamine release in the striatum. It has long been hypothesized that dysregulation of subcortical dopamine systems in schizophrenia might result from a failure of the prefrontal cortex (PFC) to adequately control subcortical dopaminergic function. The activity of midbrain dopaminergic neurons is regulated, in part, by glutamatergic projections from the PFC acting via glutamatergic N-methyl-D-aspartate (NMDA) receptors. The goal of this study was to test the hypothesis that a pharmacologically induced disruption of NMDA transmission leads to an increase in amphetamine-induced dopamine release in humans.In eight healthy volunteers, we compared striatal amphetamine-induced (0.25 mg/kg) dopamine release under control conditions and under sustained disruption of NMDA transmission induced by infusion of the noncompetitive NMDA antagonist ketamine (0.2 mg/kg intravenous bolus followed by 0.4 mg/kg/hour intravenous infusion for 4 hours). Amphetamine-induced dopamine release was determined with single photon emission computed tomography, as the reduction in the binding potential (BP) of the radiolabeled D(2) receptor antagonist [(123)I]IBZM.Ketamine significantly enhanced the amphetamine-induced decrease in [(123)I]IBZM BP, from -5.5% +/- 3.5% under control conditions to -12. 8% +/- 8.8% under ketamine pretreatment (repeated-measures analysis of variance, p =.023).The increase in amphetamine-induced dopamine release induced by ketamine (greater than twofold) was comparable in magnitude to the exaggerated response seen in patients with schizophrenia. These data are consistent with the hypothesis that the alteration of dopamine release revealed by amphetamine challenge in schizophrenia results from a disruption of glutamatergic neuronal systems regulating dopaminergic cell activity." @default.
- W2092802479 created "2016-06-24" @default.
- W2092802479 creator A5022050377 @default.
- W2092802479 creator A5027146487 @default.
- W2092802479 creator A5030014983 @default.
- W2092802479 creator A5038932065 @default.
- W2092802479 creator A5058205666 @default.
- W2092802479 creator A5072395467 @default.
- W2092802479 creator A5077060587 @default.
- W2092802479 creator A5084979953 @default.
- W2092802479 creator A5087635866 @default.
- W2092802479 date "2000-10-01" @default.
- W2092802479 modified "2023-10-15" @default.
- W2092802479 title "Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia" @default.
- W2092802479 cites W1579194285 @default.
- W2092802479 cites W1589353809 @default.
- W2092802479 cites W1914381346 @default.
- W2092802479 cites W1920051648 @default.
- W2092802479 cites W192936045 @default.
- W2092802479 cites W1964804335 @default.
- W2092802479 cites W1965138269 @default.
- W2092802479 cites W1965792012 @default.
- W2092802479 cites W1968940836 @default.
- W2092802479 cites W1969761142 @default.
- W2092802479 cites W1970814820 @default.
- W2092802479 cites W1971851906 @default.
- W2092802479 cites W1972253384 @default.
- W2092802479 cites W1972300132 @default.
- W2092802479 cites W1978196348 @default.
- W2092802479 cites W1981860820 @default.
- W2092802479 cites W1982556596 @default.
- W2092802479 cites W1982835775 @default.
- W2092802479 cites W1983138582 @default.
- W2092802479 cites W1984733445 @default.
- W2092802479 cites W1988836643 @default.
- W2092802479 cites W1990005524 @default.
- W2092802479 cites W1992894736 @default.
- W2092802479 cites W1995362640 @default.
- W2092802479 cites W1996327177 @default.
- W2092802479 cites W1997763966 @default.
- W2092802479 cites W1999084893 @default.
- W2092802479 cites W2003927131 @default.
- W2092802479 cites W2005622831 @default.
- W2092802479 cites W2006122360 @default.
- W2092802479 cites W2007135845 @default.
- W2092802479 cites W2009195573 @default.
- W2092802479 cites W2009447429 @default.
- W2092802479 cites W2011301983 @default.
- W2092802479 cites W2011434472 @default.
- W2092802479 cites W2013886916 @default.
- W2092802479 cites W2016179289 @default.
- W2092802479 cites W2016723993 @default.
- W2092802479 cites W2020844317 @default.
- W2092802479 cites W2027437909 @default.
- W2092802479 cites W2028884770 @default.
- W2092802479 cites W2029925498 @default.
- W2092802479 cites W2030160228 @default.
- W2092802479 cites W2034966218 @default.
- W2092802479 cites W2035803376 @default.
- W2092802479 cites W2038409107 @default.
- W2092802479 cites W2040737559 @default.
- W2092802479 cites W2041474029 @default.
- W2092802479 cites W2042391150 @default.
- W2092802479 cites W2043354652 @default.
- W2092802479 cites W2048024033 @default.
- W2092802479 cites W2051054399 @default.
- W2092802479 cites W2052903757 @default.
- W2092802479 cites W2054153218 @default.
- W2092802479 cites W2054230322 @default.
- W2092802479 cites W2055069006 @default.
- W2092802479 cites W2056348249 @default.
- W2092802479 cites W2057192614 @default.
- W2092802479 cites W2060040098 @default.
- W2092802479 cites W2061506085 @default.
- W2092802479 cites W2068216696 @default.
- W2092802479 cites W2070410596 @default.
- W2092802479 cites W2076704115 @default.
- W2092802479 cites W2077609442 @default.
- W2092802479 cites W2077726925 @default.
- W2092802479 cites W2080319756 @default.
- W2092802479 cites W2082055276 @default.
- W2092802479 cites W2084760609 @default.
- W2092802479 cites W2085360366 @default.
- W2092802479 cites W2086630929 @default.
- W2092802479 cites W2087057931 @default.
- W2092802479 cites W2088728916 @default.
- W2092802479 cites W2089319733 @default.
- W2092802479 cites W2089543570 @default.
- W2092802479 cites W2091155334 @default.
- W2092802479 cites W2091449747 @default.
- W2092802479 cites W2092902644 @default.
- W2092802479 cites W2093248761 @default.
- W2092802479 cites W2094572426 @default.
- W2092802479 cites W2099078941 @default.
- W2092802479 cites W2099208652 @default.
- W2092802479 cites W2104208215 @default.
- W2092802479 cites W2110143119 @default.
- W2092802479 cites W2113941649 @default.