Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092807284> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2092807284 endingPage "190" @default.
- W2092807284 startingPage "189" @default.
- W2092807284 abstract "Ezetimibe is a cholesterol absorption inhibitors that blocks the intestinal absorption of cholesterol and biliary cholesterol without affecting the uptake of triglyceride or fat-soluble vitamins. The co-administration of ezetimibe with statin has been shown to produce significant incremental reduction in LDL-C beyond that achieved with statin therapy alone. The efficacy and safety of this strategy has been studied in a several trials in a great number of patients. The mean difference between treatments significantly favoured the ezetimibe/statin combination over placebo/statin for total cholesterol (p < 0.0001), LDL-C (p < 0.0001) and HDL-C (p < 0.0001). The probability of reaching the LDL-C treatment goal was significantly higher for patients on ezetimibe/statin relative to those on placebo/ statin (p < 0.0001). Elevations in creatine kinase, alanine aminotransferase or aspartate aminotransferase that were considered as an adverse effect did not differ significantly between treatments. Ezetimibe co-administered with ongoing statin therapy provides significant additional lipid-lowering in patients not at LDL-C goal on statin therapy alone, allowing more patients to reach their LDL-C goal with no increment in the side-effects. Keywords: Ezetimibe, statins, cholesterol, LDL, HDL, meta-analysis, safety" @default.
- W2092807284 created "2016-06-24" @default.
- W2092807284 creator A5003779770 @default.
- W2092807284 creator A5045127783 @default.
- W2092807284 date "2008-06-01" @default.
- W2092807284 modified "2023-10-18" @default.
- W2092807284 title "Combination Therapy of Statins with Ezetimibe" @default.
- W2092807284 doi "https://doi.org/10.2174/187152208784587953" @default.
- W2092807284 hasPublicationYear "2008" @default.
- W2092807284 type Work @default.
- W2092807284 sameAs 2092807284 @default.
- W2092807284 citedByCount "0" @default.
- W2092807284 crossrefType "journal-article" @default.
- W2092807284 hasAuthorship W2092807284A5003779770 @default.
- W2092807284 hasAuthorship W2092807284A5045127783 @default.
- W2092807284 hasConcept C126322002 @default.
- W2092807284 hasConcept C134018914 @default.
- W2092807284 hasConcept C142724271 @default.
- W2092807284 hasConcept C197934379 @default.
- W2092807284 hasConcept C204787440 @default.
- W2092807284 hasConcept C27081682 @default.
- W2092807284 hasConcept C2776839432 @default.
- W2092807284 hasConcept C2776999253 @default.
- W2092807284 hasConcept C2777482532 @default.
- W2092807284 hasConcept C2778163477 @default.
- W2092807284 hasConcept C2778657065 @default.
- W2092807284 hasConcept C2778913445 @default.
- W2092807284 hasConcept C2780499067 @default.
- W2092807284 hasConcept C36880943 @default.
- W2092807284 hasConcept C71924100 @default.
- W2092807284 hasConcept C90924648 @default.
- W2092807284 hasConcept C98274493 @default.
- W2092807284 hasConceptScore W2092807284C126322002 @default.
- W2092807284 hasConceptScore W2092807284C134018914 @default.
- W2092807284 hasConceptScore W2092807284C142724271 @default.
- W2092807284 hasConceptScore W2092807284C197934379 @default.
- W2092807284 hasConceptScore W2092807284C204787440 @default.
- W2092807284 hasConceptScore W2092807284C27081682 @default.
- W2092807284 hasConceptScore W2092807284C2776839432 @default.
- W2092807284 hasConceptScore W2092807284C2776999253 @default.
- W2092807284 hasConceptScore W2092807284C2777482532 @default.
- W2092807284 hasConceptScore W2092807284C2778163477 @default.
- W2092807284 hasConceptScore W2092807284C2778657065 @default.
- W2092807284 hasConceptScore W2092807284C2778913445 @default.
- W2092807284 hasConceptScore W2092807284C2780499067 @default.
- W2092807284 hasConceptScore W2092807284C36880943 @default.
- W2092807284 hasConceptScore W2092807284C71924100 @default.
- W2092807284 hasConceptScore W2092807284C90924648 @default.
- W2092807284 hasConceptScore W2092807284C98274493 @default.
- W2092807284 hasIssue "2" @default.
- W2092807284 hasLocation W20928072841 @default.
- W2092807284 hasOpenAccess W2092807284 @default.
- W2092807284 hasPrimaryLocation W20928072841 @default.
- W2092807284 hasRelatedWork W2024710754 @default.
- W2092807284 hasRelatedWork W2026291721 @default.
- W2092807284 hasRelatedWork W2032483368 @default.
- W2092807284 hasRelatedWork W2119209291 @default.
- W2092807284 hasRelatedWork W2149237513 @default.
- W2092807284 hasRelatedWork W2498434420 @default.
- W2092807284 hasRelatedWork W2520240505 @default.
- W2092807284 hasRelatedWork W2606761003 @default.
- W2092807284 hasRelatedWork W2904558057 @default.
- W2092807284 hasRelatedWork W3091855412 @default.
- W2092807284 hasVolume "8" @default.
- W2092807284 isParatext "false" @default.
- W2092807284 isRetracted "false" @default.
- W2092807284 magId "2092807284" @default.
- W2092807284 workType "article" @default.