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- W2092808103 abstract "Benincasa hispida in Korea was used mainly diabetes and diuresis diseases. This study was carried out to evaluate anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor found in various tumors. In this study, we found that the seed extract of Benincasa hispida Cogniaux decreased bFGF-induced endothelial cell proliferation and tube formation in a dose-dependent manner. Besides, Benincasa hispida seed extract showed no cytotoxicity on HUVECs and normal fibroblast cells. Furthermore, the seed extract of Benincasa hispida showed a potent inhibitory effect on bFGF-induced angiogenesis in vivo. These results suggest that the seed extract of Benincasa hispida inhibits the proliferation of endothelial cells induced by bFGF, which may explain its anti-angiogenic properties." @default.
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- W2092808103 date "2005-03-01" @default.
- W2092808103 modified "2023-10-13" @default.
- W2092808103 title "Anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux" @default.
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- W2092808103 doi "https://doi.org/10.1016/j.jep.2004.12.008" @default.
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