Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092808141> ?p ?o ?g. }
- W2092808141 endingPage "617" @default.
- W2092808141 startingPage "607" @default.
- W2092808141 abstract "Synthetic alkylphospholipids (APLs), exhibit similarity to the platelet-activating factor (PAF). These compounds have antiproliferative effects on tumour cells and can therefore be regarded as a new class of drugs. Unlike classic cytostatic agents, synthetic alkylphospholipids do not interfere with the DNA or the mitotic spindle apparatus. Instead, due to their aliphatic character, alkylphospholipids accumulate in cell membranes, where they have an impact on lipid metabolism and lipid-dependent signalling pathways which leads to inhibition of proliferation and induction of apoptosis in malignant cells. Normal cells remain unaffected by these compounds. Glycosidated phospholipids, are a novel class of alkylphospholipids, in which carbohydrates or carbohydrate-related molecules are introduced in the chemical lead of PAF. These hybrid alkylphospholipids also exhibit anti-proliferative capacity. Furthermore, members of this subfamily also modulate cell adhesion, differentiation, apoptosis and migration of tumour cells. Among the members of this group, Inositol-C2-platelet-activating factor (Ino-C2-PAF) is the most effective compound developed so far. Recently, we also showed that Ino-C2-PAF exhibited the strongest impact on the gene expression levels of immortalised keratinocytes in comparison to edelfosine and another glycosidated alkylphospholipid, Glucose-platelet-activating factor (Glc-PAF). Furthermore, Ino-C2-PAF reduced the expression of genes encoding proteins associated with inflammation and the innate and acquired immune responses." @default.
- W2092808141 created "2016-06-24" @default.
- W2092808141 creator A5009731881 @default.
- W2092808141 creator A5075850310 @default.
- W2092808141 creator A5086599742 @default.
- W2092808141 creator A5091371762 @default.
- W2092808141 date "2014-04-01" @default.
- W2092808141 modified "2023-10-02" @default.
- W2092808141 title "Glycosidated Phospholipids – a Promising Group of Anti-Tumour Lipids" @default.
- W2092808141 cites W11768824 @default.
- W2092808141 cites W12170387 @default.
- W2092808141 cites W1491401160 @default.
- W2092808141 cites W1557259482 @default.
- W2092808141 cites W1561474071 @default.
- W2092808141 cites W1561554950 @default.
- W2092808141 cites W1568678089 @default.
- W2092808141 cites W1573008064 @default.
- W2092808141 cites W1575938373 @default.
- W2092808141 cites W1602490654 @default.
- W2092808141 cites W1607999229 @default.
- W2092808141 cites W1608445399 @default.
- W2092808141 cites W1773841220 @default.
- W2092808141 cites W1849452663 @default.
- W2092808141 cites W1905780755 @default.
- W2092808141 cites W1965990791 @default.
- W2092808141 cites W1974381618 @default.
- W2092808141 cites W1978760295 @default.
- W2092808141 cites W1979073481 @default.
- W2092808141 cites W1980815474 @default.
- W2092808141 cites W1984961720 @default.
- W2092808141 cites W1985426569 @default.
- W2092808141 cites W1986030520 @default.
- W2092808141 cites W1988546147 @default.
- W2092808141 cites W1990065094 @default.
- W2092808141 cites W1992925022 @default.
- W2092808141 cites W1993274199 @default.
- W2092808141 cites W1999536886 @default.
- W2092808141 cites W2001225313 @default.
- W2092808141 cites W2002718216 @default.
- W2092808141 cites W2003933642 @default.
- W2092808141 cites W2004538436 @default.
- W2092808141 cites W2006209880 @default.
- W2092808141 cites W2007201800 @default.
- W2092808141 cites W2009007155 @default.
- W2092808141 cites W2011246962 @default.
- W2092808141 cites W2012967999 @default.
- W2092808141 cites W2014960095 @default.
- W2092808141 cites W2017607160 @default.
- W2092808141 cites W2022574738 @default.
- W2092808141 cites W2028919673 @default.
- W2092808141 cites W2029065481 @default.
- W2092808141 cites W2029172172 @default.
- W2092808141 cites W2034065256 @default.
- W2092808141 cites W2034138609 @default.
- W2092808141 cites W2034714262 @default.
- W2092808141 cites W2035006492 @default.
- W2092808141 cites W2038685526 @default.
- W2092808141 cites W2042503869 @default.
- W2092808141 cites W2043819590 @default.
- W2092808141 cites W2044895919 @default.
- W2092808141 cites W2045802427 @default.
- W2092808141 cites W2047250342 @default.
- W2092808141 cites W2047558995 @default.
- W2092808141 cites W2049619479 @default.
- W2092808141 cites W2050536087 @default.
- W2092808141 cites W2051017409 @default.
- W2092808141 cites W2051808238 @default.
- W2092808141 cites W2052546028 @default.
- W2092808141 cites W2055330678 @default.
- W2092808141 cites W2055718756 @default.
- W2092808141 cites W2057434487 @default.
- W2092808141 cites W2059846269 @default.
- W2092808141 cites W2060666137 @default.
- W2092808141 cites W2062491316 @default.
- W2092808141 cites W2063638849 @default.
- W2092808141 cites W2071164030 @default.
- W2092808141 cites W2073933243 @default.
- W2092808141 cites W2074337275 @default.
- W2092808141 cites W2074690339 @default.
- W2092808141 cites W2076146195 @default.
- W2092808141 cites W2076635537 @default.
- W2092808141 cites W2080368711 @default.
- W2092808141 cites W2085304257 @default.
- W2092808141 cites W2085381842 @default.
- W2092808141 cites W2086068665 @default.
- W2092808141 cites W2086296240 @default.
- W2092808141 cites W2092121384 @default.
- W2092808141 cites W2093779834 @default.
- W2092808141 cites W2099110265 @default.
- W2092808141 cites W2100982243 @default.
- W2092808141 cites W2101667293 @default.
- W2092808141 cites W2102145679 @default.
- W2092808141 cites W2107550595 @default.
- W2092808141 cites W2112006376 @default.
- W2092808141 cites W2122057254 @default.
- W2092808141 cites W2126107341 @default.
- W2092808141 cites W2130838656 @default.
- W2092808141 cites W2141941251 @default.