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• W2092812602 abstract "Emerging resistance against well-established anti-malaria drugs warrants the introduction of new therapeutic agents with original mechanisms of action. Inhibition of membrane-based phospholipid biosynthesis, which is crucial for the parasite, has thus been proposed as a novel and promising therapeutic strategy. This review compiles literature concerning the design and study of choline analogues and related cation derivatives as potential anti-malarials. It covers advances achieved over the last two decades and describes: the concept validation, the design and selection of a clinical candidate (Albitiazolium), back-up derivatives while also providing insight into the development of prodrug approaches." @default.
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• W2092812602 date "2012-01-01" @default.
• W2092812602 modified "2023-10-09" @default.
• W2092812602 title "Choline Analogues in Malaria Chemotherapy" @default.
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• W2092812602 doi "https://doi.org/10.2174/138161212801327338" @default.
• W2092812602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3480700" @default.
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