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• W2092813388 abstract "Our recent study of the microRNA expression signature of prostate cancer (PCa) revealed that microRNA-224 (miR-224) is significantly downregulated in PCa tissues. Here, we found that restoration of miR-224 significantly inhibits PCa cell migration and invasion. Additionally, we found that oncogenic TPD52 is a direct target of miR-224 regulation. Silencing of the TPD52 gene significantly inhibits cancer cell migration and invasion. Moreover, TPD52 expression is upregulated in cancer tissues and negatively correlates with miR-224 expression. We conclude that loss of tumour-suppressive miR-224 enhances cancer cell migration and invasion in PCa through direct regulation of oncogenic TPD52." @default.
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• W2092813388 date "2014-04-24" @default.
• W2092813388 modified "2023-10-12" @default.
• W2092813388 title "Tumour-suppressive<i>microRNA-224</i>inhibits cancer cell migration and invasion via targeting oncogenic<i>TPD52</i>in prostate cancer" @default.
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• W2092813388 doi "https://doi.org/10.1016/j.febslet.2014.04.020" @default.
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