Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092822223> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2092822223 endingPage "2548" @default.
- W2092822223 startingPage "2543" @default.
- W2092822223 abstract "It was found previously that alphaB-crystallin, a small heat-shock protein, was overexpressed in a metastatic variant of the GI101A human breast carcinoma cell line. The objective of the current study was to determine whether the expression of alphaB-crystallin in primary breast carcinomas was associated with lymph node metastasis and survival.Expression of alphaB-crystallin was measured in human breast carcinoma cell lines by immunoblotting. Expression in human breast carcinomas was evaluated by immunohistochemical staining of tissue microarrays that contained samples from 317 patients with lymph node-negative breast carcinoma and 291 patients with lymph node-positive breast carcinoma.It was found that alphaB-crystallin was expressed constitutively in certain breast carcinoma cell lines, including those that were capable of metastasizing in immunodeficient mice. Expression of alphaB-crystallin in human tissue samples was associated strongly with lymph node involvement (P < 0.0001; chi-square test) and, to a lesser degree, with high nuclear grade (P = 0.05). Increased intensity of expression was correlated with shorter survival (P = 0.0091; log-rank test). Multivariate analysis indicated that alphaB-crystallin expression was not independent of lymph node status as a predictor of survival.The data obtained in the current study revealed a strong association between high expression levels of alphaB-crystallin in primary breast carcinoma specimens and lymph node involvement. Further studies will be needed to prospectively elucidate the role of this novel tumor marker as a clinical prognostic marker in local and locally advanced breast carcinoma as well as its potential status as a new target for therapy in patients with breast carcinoma." @default.
- W2092822223 created "2016-06-24" @default.
- W2092822223 creator A5001175430 @default.
- W2092822223 creator A5027326018 @default.
- W2092822223 creator A5034278269 @default.
- W2092822223 creator A5053016054 @default.
- W2092822223 creator A5061144291 @default.
- W2092822223 date "2004-01-01" @default.
- W2092822223 modified "2023-09-23" @default.
- W2092822223 title "?B-crystallin as a marker of lymph node involvement in breast carcinoma" @default.
- W2092822223 cites W1577757266 @default.
- W2092822223 cites W1683598352 @default.
- W2092822223 cites W1949238489 @default.
- W2092822223 cites W1964338529 @default.
- W2092822223 cites W1998297552 @default.
- W2092822223 cites W2019175855 @default.
- W2092822223 cites W2034269086 @default.
- W2092822223 cites W2035531438 @default.
- W2092822223 cites W2049596750 @default.
- W2092822223 cites W2061500777 @default.
- W2092822223 cites W2067100741 @default.
- W2092822223 cites W2092721181 @default.
- W2092822223 cites W2128985829 @default.
- W2092822223 cites W2148982122 @default.
- W2092822223 cites W2164060511 @default.
- W2092822223 cites W2168561598 @default.
- W2092822223 doi "https://doi.org/10.1002/cncr.20304" @default.
- W2092822223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15197794" @default.
- W2092822223 hasPublicationYear "2004" @default.
- W2092822223 type Work @default.
- W2092822223 sameAs 2092822223 @default.
- W2092822223 citedByCount "66" @default.
- W2092822223 countsByYear W20928222232012 @default.
- W2092822223 countsByYear W20928222232013 @default.
- W2092822223 countsByYear W20928222232014 @default.
- W2092822223 countsByYear W20928222232015 @default.
- W2092822223 countsByYear W20928222232016 @default.
- W2092822223 countsByYear W20928222232019 @default.
- W2092822223 countsByYear W20928222232020 @default.
- W2092822223 countsByYear W20928222232022 @default.
- W2092822223 countsByYear W20928222232023 @default.
- W2092822223 crossrefType "journal-article" @default.
- W2092822223 hasAuthorship W2092822223A5001175430 @default.
- W2092822223 hasAuthorship W2092822223A5027326018 @default.
- W2092822223 hasAuthorship W2092822223A5034278269 @default.
- W2092822223 hasAuthorship W2092822223A5053016054 @default.
- W2092822223 hasAuthorship W2092822223A5061144291 @default.
- W2092822223 hasBestOaLocation W20928222231 @default.
- W2092822223 hasConcept C121608353 @default.
- W2092822223 hasConcept C126322002 @default.
- W2092822223 hasConcept C142724271 @default.
- W2092822223 hasConcept C143998085 @default.
- W2092822223 hasConcept C193270364 @default.
- W2092822223 hasConcept C204232928 @default.
- W2092822223 hasConcept C2777546739 @default.
- W2092822223 hasConcept C2780849966 @default.
- W2092822223 hasConcept C3018521938 @default.
- W2092822223 hasConcept C502942594 @default.
- W2092822223 hasConcept C530470458 @default.
- W2092822223 hasConcept C71924100 @default.
- W2092822223 hasConceptScore W2092822223C121608353 @default.
- W2092822223 hasConceptScore W2092822223C126322002 @default.
- W2092822223 hasConceptScore W2092822223C142724271 @default.
- W2092822223 hasConceptScore W2092822223C143998085 @default.
- W2092822223 hasConceptScore W2092822223C193270364 @default.
- W2092822223 hasConceptScore W2092822223C204232928 @default.
- W2092822223 hasConceptScore W2092822223C2777546739 @default.
- W2092822223 hasConceptScore W2092822223C2780849966 @default.
- W2092822223 hasConceptScore W2092822223C3018521938 @default.
- W2092822223 hasConceptScore W2092822223C502942594 @default.
- W2092822223 hasConceptScore W2092822223C530470458 @default.
- W2092822223 hasConceptScore W2092822223C71924100 @default.
- W2092822223 hasIssue "12" @default.
- W2092822223 hasLocation W20928222231 @default.
- W2092822223 hasLocation W20928222232 @default.
- W2092822223 hasOpenAccess W2092822223 @default.
- W2092822223 hasPrimaryLocation W20928222231 @default.
- W2092822223 hasRelatedWork W1974154390 @default.
- W2092822223 hasRelatedWork W2050140073 @default.
- W2092822223 hasRelatedWork W2092822223 @default.
- W2092822223 hasRelatedWork W2143691587 @default.
- W2092822223 hasRelatedWork W2338318399 @default.
- W2092822223 hasRelatedWork W2357701734 @default.
- W2092822223 hasRelatedWork W2358565899 @default.
- W2092822223 hasRelatedWork W2758845789 @default.
- W2092822223 hasRelatedWork W3121824331 @default.
- W2092822223 hasRelatedWork W4239151826 @default.
- W2092822223 hasVolume "100" @default.
- W2092822223 isParatext "false" @default.
- W2092822223 isRetracted "false" @default.
- W2092822223 magId "2092822223" @default.
- W2092822223 workType "article" @default.