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• W2092825274 endingPage "12953" @default.
• W2092825274 startingPage "12945" @default.
• W2092825274 abstract "Abstract The preparation of thermoresponsive drug carriers with a self‐destruction property is presented. These drug carriers were fabricated by incorporation of drug molecules and thermoresponsive copolymer, poly( N ‐isopropylacrylamide‐ co ‐acrylamide), into silica nanoparticles in a one‐pot preparation process. The enhanced drug release was primarily attributed to faster molecule diffusion resulting from the particle decomposition triggered by phase transformation of the copolymer upon the temperature change. The decomposition of the drug carriers into small fragments should benefit their fast excretion from the body. In addition, the resulting drug‐loaded nanoparticles showed faster drug release in an acidic environment (pH 5) than in a neutral one. The controlled drug release of methylene blue and doxorubicin hydrochloride and the self‐decomposition of the drug carriers were successfully characterized by using TEM, UV/Vis spectroscopy, and confocal microscopy. Together with the nontoxicity and excellent biocompatibility of the copolymer/SiO 2 composite, the features of controlled drug release and simultaneous carrier self‐destruction provided a promising opportunity for designing various novel drug‐delivery systems." @default.
• W2092825274 created "2016-06-24" @default.
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• W2092825274 date "2014-08-08" @default.
• W2092825274 modified "2023-10-18" @default.
• W2092825274 title "Thermoresponsive Copolymer/SiO₂Nanoparticles with Dual Functions of Thermally Controlled Drug Release and Simultaneous Carrier Decomposition" @default.
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• W2092825274 doi "https://doi.org/10.1002/chem.201402836" @default.
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• W2092825274 hasPublicationYear "2014" @default.
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