FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092828305> ?p ?o ?g. }

• W2092828305 endingPage "21" @default.
• W2092828305 startingPage "11" @default.
• W2092828305 abstract "The metabolic effects of methylenecyclopropanepyruvate and methylenecyclopropaneacetate have been investigated. Both are formed in rat liver from the toxic compound l-α-amino-β-methylenecyclopropanepropionic acid (hypoglycin) which is present in the fruits of Blighia sapida König. 1. The production of CO2in vivo in hypoglycin-poisoned rats is diminished, mainly due to a reduction in palmitate oxidation. 2. Methylenecyclopropanepyruvate slightly inhibits the decarboxylation of 1-14C pyruvate in mitochondria whereas methylenecyclopropaneacetate does not affect the oxidation of 2-14C pyruvate. 3. Methylenecyclopropaneacetate inhibits in mitochondria the oxidation of C12- to C18-fatty acids but not that of C4- to C10-fatty acids. 4. Oxidative phosphorylation in mitochondria is uncoupled and respiration inhibited by methylenecyclopropaneacetate. No uncoupling effect is observed in submitochondrial digitonin particles. 5. Acetoacetate production from palmitate in mitochondria is inhibited by methylenecyclopropaneacetate at concentrations which do not affect fatty acid oxidation. 6. The incorporation of acetate into cholesterol is inhibited, whereas that of mevalonate is unimpaired in the presence of methylenecyclopropaneacetate. 7. It is suggested that hypoglycin toxicity is due to the formation of methylenecyclopropaneacetate which inhibits the oxidation of fatty acids. Their accumulation decreases respiration and uncouples phosphorylation." @default.
• W2092828305 created "2016-06-24" @default.
• W2092828305 creator A5017433553 @default.
• W2092828305 creator A5024420098 @default.
• W2092828305 creator A5038174579 @default.
• W2092828305 date "1966-08-01" @default.
• W2092828305 modified "2023-09-27" @default.
• W2092828305 title "Metabolic effects of hypoglycin and methylenecyclopropaneacetic acid" @default.
• W2092828305 cites W126864726 @default.
• W2092828305 cites W139435559 @default.
• W2092828305 cites W1487338389 @default.
• W2092828305 cites W1500243384 @default.
• W2092828305 cites W1593480024 @default.
• W2092828305 cites W163715235 @default.
• W2092828305 cites W1966132808 @default.
• W2092828305 cites W1970479313 @default.
• W2092828305 cites W1973047931 @default.
• W2092828305 cites W1976113751 @default.
• W2092828305 cites W198887605 @default.
• W2092828305 cites W1996843726 @default.
• W2092828305 cites W2005735000 @default.
• W2092828305 cites W2010798811 @default.
• W2092828305 cites W2018681000 @default.
• W2092828305 cites W2029402191 @default.
• W2092828305 cites W2068957735 @default.
• W2092828305 cites W2071647319 @default.
• W2092828305 cites W2073316804 @default.
• W2092828305 cites W2088515555 @default.
• W2092828305 cites W2089043896 @default.
• W2092828305 cites W2120203612 @default.
• W2092828305 cites W2129345264 @default.
• W2092828305 cites W2313308587 @default.
• W2092828305 cites W2321259617 @default.
• W2092828305 cites W2322440080 @default.
• W2092828305 cites W2334728399 @default.
• W2092828305 cites W2396614243 @default.
• W2092828305 cites W2408764159 @default.
• W2092828305 cites W2409833084 @default.
• W2092828305 cites W2410366896 @default.
• W2092828305 cites W2433732665 @default.
• W2092828305 cites W48316491 @default.
• W2092828305 doi "https://doi.org/10.1016/0005-2760(66)90139-1" @default.
• W2092828305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5968584" @default.
• W2092828305 hasPublicationYear "1966" @default.
• W2092828305 type Work @default.
• W2092828305 sameAs 2092828305 @default.
• W2092828305 citedByCount "74" @default.
• W2092828305 countsByYear W20928283052012 @default.
• W2092828305 countsByYear W20928283052015 @default.
• W2092828305 countsByYear W20928283052017 @default.
• W2092828305 countsByYear W20928283052018 @default.
• W2092828305 countsByYear W20928283052023 @default.
• W2092828305 crossrefType "journal-article" @default.
• W2092828305 hasAuthorship W2092828305A5017433553 @default.
• W2092828305 hasAuthorship W2092828305A5024420098 @default.
• W2092828305 hasAuthorship W2092828305A5038174579 @default.
• W2092828305 hasConcept C161790260 @default.
• W2092828305 hasConcept C181199279 @default.
• W2092828305 hasConcept C185592680 @default.
• W2092828305 hasConcept C2778389096 @default.
• W2092828305 hasConcept C2778920010 @default.
• W2092828305 hasConcept C2779634684 @default.
• W2092828305 hasConcept C2780595602 @default.
• W2092828305 hasConcept C28859421 @default.
• W2092828305 hasConcept C543025807 @default.
• W2092828305 hasConcept C55493867 @default.
• W2092828305 hasConcept C57600042 @default.
• W2092828305 hasConcept C60538801 @default.
• W2092828305 hasConcept C82714985 @default.
• W2092828305 hasConceptScore W2092828305C161790260 @default.
• W2092828305 hasConceptScore W2092828305C181199279 @default.
• W2092828305 hasConceptScore W2092828305C185592680 @default.
• W2092828305 hasConceptScore W2092828305C2778389096 @default.
• W2092828305 hasConceptScore W2092828305C2778920010 @default.
• W2092828305 hasConceptScore W2092828305C2779634684 @default.
• W2092828305 hasConceptScore W2092828305C2780595602 @default.
• W2092828305 hasConceptScore W2092828305C28859421 @default.
• W2092828305 hasConceptScore W2092828305C543025807 @default.
• W2092828305 hasConceptScore W2092828305C55493867 @default.
• W2092828305 hasConceptScore W2092828305C57600042 @default.
• W2092828305 hasConceptScore W2092828305C60538801 @default.
• W2092828305 hasConceptScore W2092828305C82714985 @default.
• W2092828305 hasIssue "1" @default.
• W2092828305 hasLocation W20928283051 @default.
• W2092828305 hasLocation W20928283052 @default.
• W2092828305 hasOpenAccess W2092828305 @default.
• W2092828305 hasPrimaryLocation W20928283051 @default.
• W2092828305 hasRelatedWork W1942677777 @default.
• W2092828305 hasRelatedWork W1978344098 @default.
• W2092828305 hasRelatedWork W2023285574 @default.
• W2092828305 hasRelatedWork W2038620413 @default.
• W2092828305 hasRelatedWork W2045818454 @default.
• W2092828305 hasRelatedWork W2056669242 @default.
• W2092828305 hasRelatedWork W2092828305 @default.
• W2092828305 hasRelatedWork W2126075295 @default.
• W2092828305 hasRelatedWork W3101537 @default.
• W2092828305 hasRelatedWork W81788848 @default.
• W2092828305 hasVolume "125" @default.

• next