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- W2092829197 abstract "The hypocholesterolemic effect of 2-methoxyestrone (2-MeOE1), 2-methoxyestriol (2-MeOE3) and estradiol-17β (E2-17β) was investigated in 2 experimental systems of normocholesterolemic and dietary hypercholesterolemic rats that had been oopho-rectomized. Each compound was subcutaneously administered for 10 consecutive days at a dose of 10 μg per day in the former, and for 6 consecutive days at a dose of 300 μg per day in the latter. The hypocholesterolemic effect was as follows; 2-MeOE3=E2-17β>2-MeOE1. In the latter system, the serum total cholesterol level of the individual rats in both 2-MeOE3- and E2-17β-administered groups returned to normal. These hormones caused an increase of α-lipoprotein, with an inversely proportional decrease of β-lipoprotein, and the β-/α-lipoprotein ratio was in an inverse correlation with the hypocholesterolemic effect. The uterotrophic activity was detected with neither 2-MeOE1 nor 2-MeOE3, while E2-17β exhibited an anomalous activity. 2-MeOE1 and 2-MeOE3 had no effect on body weight, while E2-17β reduced it slightly. The results suggest that catecholestrogen 2-monomethyl ether plays an important role in lipid metabolism through estrogen receptor-independent mechanisms, and has a pharmacologically important effect on hyperlipidemia and atherosclerosis." @default.
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- W2092829197 date "2010-05-24" @default.
- W2092829197 modified "2023-09-27" @default.
- W2092829197 title "Effects of Catecholestrogen 2-Monomethyl Ether on Serum Cholesterol and Lipoprotein Levels" @default.
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- W2092829197 doi "https://doi.org/10.1111/j.1447-0756.1988.tb00123.x" @default.
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