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- W2092836050 abstract "Differential gene expression largely accounts for the coordinated manifestation of the genetic programme underlying embryonic development and cell differentiation. The 3′ untranslated region (3′-UTR) of eukaryotic genes can contain motifs involved in regulation of gene expression at the post-transcriptional level. In the 3′-UTR of dmrt1 , a key gene that functions in gonad development and differentiation, an 11-bp protein-binding motif was identified that mediates gonad-specific mRNA localization during embryonic and larval development of fish. Mutations that disrupt the 11-bp motif leading to in vitro protein-binding loss and selective transcript stabilization failure indicate a role for this motif in RNA stabilization through protein binding. The sequence motif was found to be conserved in most of the dmrt1 homologous genes from flies to humans suggesting a widespread conservation of this specific mechanism." @default.
- W2092836050 created "2016-06-24" @default.
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- W2092836050 date "2009-01-12" @default.
- W2092836050 modified "2023-10-16" @default.
- W2092836050 title "A highly conserved cis -regulatory motif directs differential gonadal synexpression of Dmrt1 transcripts during gonad development" @default.
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- W2092836050 doi "https://doi.org/10.1093/nar/gkn1065" @default.
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