Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092837900> ?p ?o ?g. }
- W2092837900 endingPage "77" @default.
- W2092837900 startingPage "70" @default.
- W2092837900 abstract "We analysed the type and/or subtype of 5-hydroxytryptamine (5-HT) receptors involved in the inhibitory mechanisms of 5-HT on the pressor responses induced by stimulation of sympathetic vasopressor outflow in long-term diabetic pithed rats. Diabetes was induced in male Wistar rats by a single subcutaneous injection of alloxan. Eight weeks later, rats were anaesthetized, pre-treated with atropine, and pithed. The effect of 5-HT on the pressor responses elicited by stimulation of the sympathetic outflow was analysed in eight-week alloxan-induced diabetic pithed rats. 5-HT (20 microg/kg/min) reduced the pressor action obtained by electrical stimulation of the sympathetic outflow. However, there was no effect on exogenous noradrenaline-induced pressor responses. 5-CT (5 microg/kg/min), 8-OH-DPAT (5 microg/kg/min), and alpha-methyl-5-HT (5 microg/kg/min), selective 5-HT(1), 5-HT(1A) and 5-HT(2) receptor agonists, respectively, reproduced the 5-HT inhibitory action. Nevertheless, infusion of 5 microg/kg/min of 1-phenylbiguanide, CGS-12066B, L-694,247, BW273C86 or MK212 (5-HT(3), 5-HT(1B), 5-HT(1D), 5-HT(2B) and 5-HT(2C) receptor agonists, respectively) had no effect on the pressor responses elicited by stimulation of the sympathetic outflow. Methiothepin (100 microg/kg) and a cocktail of WAY-100,635 (100 microg/kg) and spiperone (125 microg/kg) blocked the 5-HT inhibitory effect on the pressor action obtained by sympathetic stimulation. Moreover, WAY-100, 635 abolished the 8-OH-DPAT inhibitory effect and spiperone blocked alpha-methyl-5-HT action. In conclusion, this study revealed that long-term experimental diabetes induces changes in the receptor type/subtype involved in the 5-HT inhibitory action on the sympathetic pressor responses produced by electrical stimulation. This is mainly mediated by pre-junctional 5-HT(1A) and 5-HT(2A) receptors." @default.
- W2092837900 created "2016-06-24" @default.
- W2092837900 creator A5005513572 @default.
- W2092837900 creator A5007455462 @default.
- W2092837900 creator A5015175818 @default.
- W2092837900 creator A5041765697 @default.
- W2092837900 creator A5063198022 @default.
- W2092837900 creator A5085303195 @default.
- W2092837900 date "2010-09-01" @default.
- W2092837900 modified "2023-10-18" @default.
- W2092837900 title "Pharmacological profile of 5-hydroxytryptamine-induced inhibition on the pressor effect elicited by sympathetic stimulation in long-term diabetic pithed rats" @default.
- W2092837900 cites W1972232167 @default.
- W2092837900 cites W1973651880 @default.
- W2092837900 cites W1975494566 @default.
- W2092837900 cites W1987295255 @default.
- W2092837900 cites W1989400268 @default.
- W2092837900 cites W1990737931 @default.
- W2092837900 cites W1997005814 @default.
- W2092837900 cites W2006096816 @default.
- W2092837900 cites W2006192526 @default.
- W2092837900 cites W2007880055 @default.
- W2092837900 cites W2009845352 @default.
- W2092837900 cites W2011260230 @default.
- W2092837900 cites W2012989387 @default.
- W2092837900 cites W2014416688 @default.
- W2092837900 cites W2019368901 @default.
- W2092837900 cites W2021710039 @default.
- W2092837900 cites W2022931431 @default.
- W2092837900 cites W2024078613 @default.
- W2092837900 cites W2025981875 @default.
- W2092837900 cites W2028910646 @default.
- W2092837900 cites W2031024202 @default.
- W2092837900 cites W2036040729 @default.
- W2092837900 cites W2036764053 @default.
- W2092837900 cites W2038620688 @default.
- W2092837900 cites W2039609563 @default.
- W2092837900 cites W2041262227 @default.
- W2092837900 cites W2044756207 @default.
- W2092837900 cites W2051877191 @default.
- W2092837900 cites W2054174944 @default.
- W2092837900 cites W2057275071 @default.
- W2092837900 cites W2058501253 @default.
- W2092837900 cites W2059612248 @default.
- W2092837900 cites W2069420129 @default.
- W2092837900 cites W2074498996 @default.
- W2092837900 cites W2078589865 @default.
- W2092837900 cites W2080491963 @default.
- W2092837900 cites W2081396232 @default.
- W2092837900 cites W2083095953 @default.
- W2092837900 cites W2092621112 @default.
- W2092837900 cites W2103044440 @default.
- W2092837900 cites W2103880802 @default.
- W2092837900 cites W2116033979 @default.
- W2092837900 cites W2141198202 @default.
- W2092837900 cites W2156249695 @default.
- W2092837900 cites W2165162787 @default.
- W2092837900 cites W2166683822 @default.
- W2092837900 cites W4251761896 @default.
- W2092837900 doi "https://doi.org/10.1016/j.ejphar.2010.06.013" @default.
- W2092837900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20547148" @default.
- W2092837900 hasPublicationYear "2010" @default.
- W2092837900 type Work @default.
- W2092837900 sameAs 2092837900 @default.
- W2092837900 citedByCount "17" @default.
- W2092837900 countsByYear W20928379002012 @default.
- W2092837900 countsByYear W20928379002013 @default.
- W2092837900 countsByYear W20928379002014 @default.
- W2092837900 countsByYear W20928379002015 @default.
- W2092837900 countsByYear W20928379002016 @default.
- W2092837900 countsByYear W20928379002017 @default.
- W2092837900 countsByYear W20928379002019 @default.
- W2092837900 countsByYear W20928379002020 @default.
- W2092837900 countsByYear W20928379002021 @default.
- W2092837900 countsByYear W20928379002022 @default.
- W2092837900 countsByYear W20928379002023 @default.
- W2092837900 crossrefType "journal-article" @default.
- W2092837900 hasAuthorship W2092837900A5005513572 @default.
- W2092837900 hasAuthorship W2092837900A5007455462 @default.
- W2092837900 hasAuthorship W2092837900A5015175818 @default.
- W2092837900 hasAuthorship W2092837900A5041765697 @default.
- W2092837900 hasAuthorship W2092837900A5063198022 @default.
- W2092837900 hasAuthorship W2092837900A5085303195 @default.
- W2092837900 hasConcept C126322002 @default.
- W2092837900 hasConcept C134018914 @default.
- W2092837900 hasConcept C170493617 @default.
- W2092837900 hasConcept C17077164 @default.
- W2092837900 hasConcept C185592680 @default.
- W2092837900 hasConcept C24998067 @default.
- W2092837900 hasConcept C2775864247 @default.
- W2092837900 hasConcept C2777785214 @default.
- W2092837900 hasConcept C53910766 @default.
- W2092837900 hasConcept C71924100 @default.
- W2092837900 hasConceptScore W2092837900C126322002 @default.
- W2092837900 hasConceptScore W2092837900C134018914 @default.
- W2092837900 hasConceptScore W2092837900C170493617 @default.
- W2092837900 hasConceptScore W2092837900C17077164 @default.
- W2092837900 hasConceptScore W2092837900C185592680 @default.
- W2092837900 hasConceptScore W2092837900C24998067 @default.