Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092844218> ?p ?o ?g. }
- W2092844218 endingPage "187" @default.
- W2092844218 startingPage "179" @default.
- W2092844218 abstract "Information on the clinicopathologic characteristics of invasive carcinomas arising from mucinous cystic neoplasms (MCNs) is limited, because in many early studies they were lumped and analyzed together with noninvasive MCNs. Even more importantly, many of the largest prior studies did not require ovarian-type stroma (OTS) for diagnosis. We analyzed 178 MCNs, all strictly defined by the presence of OTS, 98% of which occurred in perimenopausal women (mean age, 47 y) and arose in the distal pancreas. Twenty-nine (16%) patients had associated invasive carcinoma, and all were female with a mean age of 53. Invasion was far more common in tumors with grossly visible intracystic papillary nodule formation ≥1.0 cm (79.3% vs. 8.7%, P=0.000) as well as in larger tumors (mean cyst size: 9.4 vs. 5.4 cm, P=0.006); only 4/29 (14%) invasive carcinomas occurred in tumors that were <5 cm; however, none were <3 cm. Increased serum CA19-9 level (>37 U/L) was also more common in the invasive tumors (64% vs. 23%, P=0.011). Most invasive carcinomas (79%) were of tubular type, and the remainder (5 cases) were mostly undifferentiated carcinoma (2, with osteoclast-like giant cells), except for 1 with papillary features. Interestingly, there were no colloid carcinomas; 2 patients had nodal metastasis at the time of diagnosis, and both died of disease at 10 and 35 months, respectively. While noninvasive MCNs had an excellent prognosis (100% at 5 y), tumors with invasion often had an aggressive clinical course with 3- and 5-year survival rates of 44% and 26%, respectively (P=0.000). The pT2 (>2 cm) invasive tumors had a worse prognosis than pT1 (≤2 cm) tumors (P=0.000), albeit 3 patients with T1a (<0.5 cm) disease also died of disease. In conclusion, invasive carcinomas are seen in 16% of MCNs and are mostly of tubular (pancreatobiliary) type; colloid carcinoma is not seen in MCNs. Serum CA19-9 is often higher in invasive carcinomas, and invasion is typically seen in OTS-depleted areas with lower progesterone receptor expression. Invasion is not seen in small tumors (<3 cm) and those lacking intracystic papillary (mural) nodules of ≥1 cm, thus making the current branch-duct intraductal papillary mucinous neoplasm management protocols also applicable to MCNs." @default.
- W2092844218 created "2016-06-24" @default.
- W2092844218 creator A5001840708 @default.
- W2092844218 creator A5014264787 @default.
- W2092844218 creator A5020547158 @default.
- W2092844218 creator A5023965369 @default.
- W2092844218 creator A5034683497 @default.
- W2092844218 creator A5040284861 @default.
- W2092844218 creator A5042273117 @default.
- W2092844218 creator A5062557528 @default.
- W2092844218 creator A5066972494 @default.
- W2092844218 creator A5069873105 @default.
- W2092844218 creator A5070241434 @default.
- W2092844218 creator A5080230233 @default.
- W2092844218 creator A5091392056 @default.
- W2092844218 date "2015-02-01" @default.
- W2092844218 modified "2023-10-14" @default.
- W2092844218 title "Clinicopathologic Characteristics of 29 Invasive Carcinomas Arising in 178 Pancreatic Mucinous Cystic Neoplasms With Ovarian-type Stroma" @default.
- W2092844218 cites W11936812 @default.
- W2092844218 cites W1517721845 @default.
- W2092844218 cites W1581154960 @default.
- W2092844218 cites W1967003831 @default.
- W2092844218 cites W1967197732 @default.
- W2092844218 cites W1968263164 @default.
- W2092844218 cites W1971852262 @default.
- W2092844218 cites W1980717136 @default.
- W2092844218 cites W1982479615 @default.
- W2092844218 cites W1990288931 @default.
- W2092844218 cites W1992595813 @default.
- W2092844218 cites W1992868024 @default.
- W2092844218 cites W2004382928 @default.
- W2092844218 cites W2010054000 @default.
- W2092844218 cites W2012055544 @default.
- W2092844218 cites W2031586352 @default.
- W2092844218 cites W2034923693 @default.
- W2092844218 cites W2041894239 @default.
- W2092844218 cites W2042954848 @default.
- W2092844218 cites W2049579872 @default.
- W2092844218 cites W2060774930 @default.
- W2092844218 cites W2065762338 @default.
- W2092844218 cites W2069751597 @default.
- W2092844218 cites W2077929220 @default.
- W2092844218 cites W2079912108 @default.
- W2092844218 cites W2086207147 @default.
- W2092844218 cites W2092021191 @default.
- W2092844218 cites W2099429654 @default.
- W2092844218 cites W2134226456 @default.
- W2092844218 cites W2135212503 @default.
- W2092844218 cites W2137245405 @default.
- W2092844218 cites W2148560417 @default.
- W2092844218 cites W2150048207 @default.
- W2092844218 cites W2163459778 @default.
- W2092844218 cites W2333027375 @default.
- W2092844218 cites W2417939891 @default.
- W2092844218 cites W2569618912 @default.
- W2092844218 cites W70276085 @default.
- W2092844218 doi "https://doi.org/10.1097/pas.0000000000000357" @default.
- W2092844218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4460193" @default.
- W2092844218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25517958" @default.
- W2092844218 hasPublicationYear "2015" @default.
- W2092844218 type Work @default.
- W2092844218 sameAs 2092844218 @default.
- W2092844218 citedByCount "96" @default.
- W2092844218 countsByYear W20928442182015 @default.
- W2092844218 countsByYear W20928442182016 @default.
- W2092844218 countsByYear W20928442182017 @default.
- W2092844218 countsByYear W20928442182018 @default.
- W2092844218 countsByYear W20928442182019 @default.
- W2092844218 countsByYear W20928442182020 @default.
- W2092844218 countsByYear W20928442182021 @default.
- W2092844218 countsByYear W20928442182022 @default.
- W2092844218 countsByYear W20928442182023 @default.
- W2092844218 crossrefType "journal-article" @default.
- W2092844218 hasAuthorship W2092844218A5001840708 @default.
- W2092844218 hasAuthorship W2092844218A5014264787 @default.
- W2092844218 hasAuthorship W2092844218A5020547158 @default.
- W2092844218 hasAuthorship W2092844218A5023965369 @default.
- W2092844218 hasAuthorship W2092844218A5034683497 @default.
- W2092844218 hasAuthorship W2092844218A5040284861 @default.
- W2092844218 hasAuthorship W2092844218A5042273117 @default.
- W2092844218 hasAuthorship W2092844218A5062557528 @default.
- W2092844218 hasAuthorship W2092844218A5066972494 @default.
- W2092844218 hasAuthorship W2092844218A5069873105 @default.
- W2092844218 hasAuthorship W2092844218A5070241434 @default.
- W2092844218 hasAuthorship W2092844218A5080230233 @default.
- W2092844218 hasAuthorship W2092844218A5091392056 @default.
- W2092844218 hasBestOaLocation W20928442182 @default.
- W2092844218 hasConcept C121608353 @default.
- W2092844218 hasConcept C126322002 @default.
- W2092844218 hasConcept C142724271 @default.
- W2092844218 hasConcept C204232928 @default.
- W2092844218 hasConcept C2777546739 @default.
- W2092844218 hasConcept C2778764654 @default.
- W2092844218 hasConcept C2779013556 @default.
- W2092844218 hasConcept C2780597408 @default.
- W2092844218 hasConcept C2780964533 @default.
- W2092844218 hasConcept C2781182431 @default.
- W2092844218 hasConcept C52124034 @default.