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• W2092854186 abstract "We demonstrate the cytotoxic potential of the Schiff base iron complex [FeIII(salophene)Cl] in vitro and ex vivo and illustrate its ability to overcome multiple drug resistance in vincristine and daunorubicine resistant leukemic cells (Nalm-6). Treatment of lymphoma cells (BJAB) with [FeIII(salophene)Cl] led to the exclusion of unspecific necrosis, a concentration-dependent inhibition of proliferation and a specific apoptotic cell death. We further detected a significant loss of the mitochondrial membrane potential in lymphoma cells and an up- and downregulation of various apoptosis relevant genes, respectively, indicating the involvement of the intrinsic mitochondrial pathway." @default.
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• W2092854186 date "2011-03-01" @default.
• W2092854186 modified "2023-10-11" @default.
• W2092854186 title "[FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells" @default.
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• W2092854186 doi "https://doi.org/10.1016/j.leukres.2010.11.007" @default.
• W2092854186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21131047" @default.
• W2092854186 hasPublicationYear "2011" @default.
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