FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092859122> ?p ?o ?g. }

• W2092859122 endingPage "775" @default.
• W2092859122 startingPage "769" @default.
• W2092859122 abstract "Summary Context The GHRH–protein kinase A (PKA) signalling pathway is essential for cell proliferation and GH synthesis/secretion in somatotrophs. An inactivating mutation of PRKAR1A is one of the causes of somatotrophinoma in Carney complex (CNC). The basal PKA activity of somatotroph adenoma cells from CNC has not been evaluated because of a limited amount of available tissue. Objective This study examined how the PRKAR1A mutation affects the PKA signalling pathway in a human somatotrophinoma with a PRKAR1A mutation. Design and setting Somatotrophinoma cells from a 40‐year‐old male patient with CNC were used. The patient had a novel somatic heterozygous germline frameshift mutation (227delT) in PRKAR1A leading to a premature stop codon. The tumour showed loss of heterozygosity (LOH) at 17q23–24. Primary cultured adenoma cells were subjected to electrophysiological experiments to evaluate PKA signalling in individual cells. Results GHRH did not increase the nonselective cation current or the voltage‐gated calcium current in these adenoma cells, in contrast to nonadenomatous somatotroph cells in which these currents increase through the PKA pathway. Application of a PKA inhibitor inhibited the basal currents in these adenoma cells, results that were not observed in nonadenomatous somatotrophs. These data indicate that the basal currents are already increased and cannot be further increased by GHRH. Conclusions The results demonstrate that PKA is activated at the basal state in these adenoma cells. The data also show that both the nonselective cation current and the voltage‐gated calcium current, vital regulators of GH secretion downstream of PKA, are maximally increased in these cells. These maximally increased currents probably account for the excessive GH secretion." @default.
• W2092859122 created "2016-06-24" @default.
• W2092859122 creator A5005530967 @default.
• W2092859122 creator A5039282044 @default.
• W2092859122 creator A5045425439 @default.
• W2092859122 creator A5049262522 @default.
• W2092859122 creator A5073046727 @default.
• W2092859122 creator A5077935582 @default.
• W2092859122 creator A5080266991 @default.
• W2092859122 creator A5089863705 @default.
• W2092859122 date "2009-03-31" @default.
• W2092859122 modified "2023-10-15" @default.
• W2092859122 title "Evidence that PKA activity is constitutively activated in human GH-secreting adenoma cells in a patient with Carney complex harbouring a<i>PRKAR1A</i>mutation" @default.
• W2092859122 cites W1544637912 @default.
• W2092859122 cites W1876974170 @default.
• W2092859122 cites W1987145801 @default.
• W2092859122 cites W1991573872 @default.
• W2092859122 cites W2016572879 @default.
• W2092859122 cites W2021421238 @default.
• W2092859122 cites W2021593686 @default.
• W2092859122 cites W2045663795 @default.
• W2092859122 cites W2045715489 @default.
• W2092859122 cites W2052998894 @default.
• W2092859122 cites W2057662724 @default.
• W2092859122 cites W2064533401 @default.
• W2092859122 cites W2117535295 @default.
• W2092859122 cites W2124127909 @default.
• W2092859122 cites W2132424280 @default.
• W2092859122 cites W2162702275 @default.
• W2092859122 cites W2171966399 @default.
• W2092859122 cites W2313361205 @default.
• W2092859122 cites W2336211344 @default.
• W2092859122 cites W2337777109 @default.
• W2092859122 cites W4242551257 @default.
• W2092859122 cites W4244889046 @default.
• W2092859122 cites W4247623842 @default.
• W2092859122 doi "https://doi.org/10.1111/j.1365-2265.2008.03457.x" @default.
• W2092859122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19178533" @default.
• W2092859122 hasPublicationYear "2009" @default.
• W2092859122 type Work @default.
• W2092859122 sameAs 2092859122 @default.
• W2092859122 citedByCount "5" @default.
• W2092859122 countsByYear W20928591222015 @default.
• W2092859122 countsByYear W20928591222018 @default.
• W2092859122 countsByYear W20928591222019 @default.
• W2092859122 countsByYear W20928591222022 @default.
• W2092859122 crossrefType "journal-article" @default.
• W2092859122 hasAuthorship W2092859122A5005530967 @default.
• W2092859122 hasAuthorship W2092859122A5039282044 @default.
• W2092859122 hasAuthorship W2092859122A5045425439 @default.
• W2092859122 hasAuthorship W2092859122A5049262522 @default.
• W2092859122 hasAuthorship W2092859122A5073046727 @default.
• W2092859122 hasAuthorship W2092859122A5077935582 @default.
• W2092859122 hasAuthorship W2092859122A5080266991 @default.
• W2092859122 hasAuthorship W2092859122A5089863705 @default.
• W2092859122 hasConcept C104317684 @default.
• W2092859122 hasConcept C11960822 @default.
• W2092859122 hasConcept C126322002 @default.
• W2092859122 hasConcept C134018914 @default.
• W2092859122 hasConcept C13514818 @default.
• W2092859122 hasConcept C2777108446 @default.
• W2092859122 hasConcept C2777428134 @default.
• W2092859122 hasConcept C2777658017 @default.
• W2092859122 hasConcept C501734568 @default.
• W2092859122 hasConcept C502942594 @default.
• W2092859122 hasConcept C54355233 @default.
• W2092859122 hasConcept C71315377 @default.
• W2092859122 hasConcept C71924100 @default.
• W2092859122 hasConcept C86803240 @default.
• W2092859122 hasConcept C94984642 @default.
• W2092859122 hasConcept C95444343 @default.
• W2092859122 hasConcept C97029542 @default.
• W2092859122 hasConceptScore W2092859122C104317684 @default.
• W2092859122 hasConceptScore W2092859122C11960822 @default.
• W2092859122 hasConceptScore W2092859122C126322002 @default.
• W2092859122 hasConceptScore W2092859122C134018914 @default.
• W2092859122 hasConceptScore W2092859122C13514818 @default.
• W2092859122 hasConceptScore W2092859122C2777108446 @default.
• W2092859122 hasConceptScore W2092859122C2777428134 @default.
• W2092859122 hasConceptScore W2092859122C2777658017 @default.
• W2092859122 hasConceptScore W2092859122C501734568 @default.
• W2092859122 hasConceptScore W2092859122C502942594 @default.
• W2092859122 hasConceptScore W2092859122C54355233 @default.
• W2092859122 hasConceptScore W2092859122C71315377 @default.
• W2092859122 hasConceptScore W2092859122C71924100 @default.
• W2092859122 hasConceptScore W2092859122C86803240 @default.
• W2092859122 hasConceptScore W2092859122C94984642 @default.
• W2092859122 hasConceptScore W2092859122C95444343 @default.
• W2092859122 hasConceptScore W2092859122C97029542 @default.
• W2092859122 hasIssue "5" @default.
• W2092859122 hasLocation W20928591221 @default.
• W2092859122 hasLocation W20928591222 @default.
• W2092859122 hasOpenAccess W2092859122 @default.
• W2092859122 hasPrimaryLocation W20928591221 @default.
• W2092859122 hasRelatedWork W1981021342 @default.
• W2092859122 hasRelatedWork W2014606351 @default.
• W2092859122 hasRelatedWork W2023511739 @default.
• W2092859122 hasRelatedWork W2234628122 @default.

• next