FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092860295> ?p ?o ?g. }

• W2092860295 endingPage "1258" @default.
• W2092860295 startingPage "1250" @default.
• W2092860295 abstract "Summary Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder caused by maternal antibodies against fetal/neonatal platelets. FNAIT is also linked with miscarriages, although the incidence and mechanisms of fetal death have not been well studied. Integrin αIIbβ3 (GPIIbIIIa) and the GPIbα complex are major glycoproteins expressed on platelets and are also major antigens targeted in autoimmune thrombocytopenia (ITP), but reported cases of anti-GPIb-mediated FNAIT are rare. Bacterial and viral infections have been causally linked with the pathogenesis of immune-mediated thrombocytopenia (ITP); however, it is unknown whether these infections contribute to the severity of FNAIT. Here, immune responses against platelet antigens were examined by transfusing wild-type (WT) mouse platelets into β3-/- or GPIbα-/- mice. To mimic bacterial or viral infections, lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (Poly I:C) were injected intraperitoneally following platelet transfusions. The FNAIT model was established by breeding the immunised female mice with WT male mice. We demonstrated for the first time that the platelet GPIbα has lower immunogenicity compared to β3 integrin. Interestingly, co-stimulation with LPS or Poly I:C markedly enhanced the immune response against platelet GPIbα and caused severe pathology of FNAIT (i.e. miscarriages). LPS or Poly I:C also enhanced the immune response against platelet β3 integrin. Our data suggest that bacterial and viral infections facilitate the anti-platelet GPIbα response, which may lead to a severe non-classical FNAIT (i.e. miscarriage but not neonatal bleeding) that has not been adequately reported in humans." @default.
• W2092860295 created "2016-06-24" @default.
• W2092860295 creator A5005738493 @default.
• W2092860295 creator A5011480176 @default.
• W2092860295 creator A5011976722 @default.
• W2092860295 creator A5031271425 @default.
• W2092860295 creator A5038856208 @default.
• W2092860295 creator A5050268815 @default.
• W2092860295 creator A5064339156 @default.
• W2092860295 creator A5076606324 @default.
• W2092860295 date "2013-01-01" @default.
• W2092860295 modified "2023-10-16" @default.
• W2092860295 title "Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia" @default.
• W2092860295 cites W138570360 @default.
• W2092860295 cites W1481853573 @default.
• W2092860295 cites W1531681292 @default.
• W2092860295 cites W1561591381 @default.
• W2092860295 cites W1602182436 @default.
• W2092860295 cites W1960939533 @default.
• W2092860295 cites W1971987125 @default.
• W2092860295 cites W1978671391 @default.
• W2092860295 cites W1979543372 @default.
• W2092860295 cites W1985705917 @default.
• W2092860295 cites W1986167289 @default.
• W2092860295 cites W1987191514 @default.
• W2092860295 cites W1987350718 @default.
• W2092860295 cites W1990625704 @default.
• W2092860295 cites W1994604751 @default.
• W2092860295 cites W1997213286 @default.
• W2092860295 cites W2001630759 @default.
• W2092860295 cites W2005347097 @default.
• W2092860295 cites W2007290046 @default.
• W2092860295 cites W2009720281 @default.
• W2092860295 cites W2011734277 @default.
• W2092860295 cites W2026624464 @default.
• W2092860295 cites W2036912261 @default.
• W2092860295 cites W2039881470 @default.
• W2092860295 cites W2044052575 @default.
• W2092860295 cites W2061033958 @default.
• W2092860295 cites W2061514779 @default.
• W2092860295 cites W2064117411 @default.
• W2092860295 cites W2064882706 @default.
• W2092860295 cites W2075018860 @default.
• W2092860295 cites W2075041376 @default.
• W2092860295 cites W2076153582 @default.
• W2092860295 cites W2087702773 @default.
• W2092860295 cites W2091803695 @default.
• W2092860295 cites W2097591338 @default.
• W2092860295 cites W2110320870 @default.
• W2092860295 cites W2123558747 @default.
• W2092860295 cites W2123992009 @default.
• W2092860295 cites W2150693754 @default.
• W2092860295 cites W2157711480 @default.
• W2092860295 cites W2158608092 @default.
• W2092860295 cites W2167199751 @default.
• W2092860295 cites W2341709626 @default.
• W2092860295 cites W2462430545 @default.
• W2092860295 cites W83303467 @default.
• W2092860295 doi "https://doi.org/10.1160/th13-04-0354" @default.
• W2092860295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24067944" @default.
• W2092860295 hasPublicationYear "2013" @default.
• W2092860295 type Work @default.
• W2092860295 sameAs 2092860295 @default.
• W2092860295 citedByCount "19" @default.
• W2092860295 countsByYear W20928602952015 @default.
• W2092860295 countsByYear W20928602952016 @default.
• W2092860295 countsByYear W20928602952017 @default.
• W2092860295 countsByYear W20928602952018 @default.
• W2092860295 countsByYear W20928602952019 @default.
• W2092860295 countsByYear W20928602952020 @default.
• W2092860295 countsByYear W20928602952021 @default.
• W2092860295 countsByYear W20928602952023 @default.
• W2092860295 crossrefType "journal-article" @default.
• W2092860295 hasAuthorship W2092860295A5005738493 @default.
• W2092860295 hasAuthorship W2092860295A5011480176 @default.
• W2092860295 hasAuthorship W2092860295A5011976722 @default.
• W2092860295 hasAuthorship W2092860295A5031271425 @default.
• W2092860295 hasAuthorship W2092860295A5038856208 @default.
• W2092860295 hasAuthorship W2092860295A5050268815 @default.
• W2092860295 hasAuthorship W2092860295A5064339156 @default.
• W2092860295 hasAuthorship W2092860295A5076606324 @default.
• W2092860295 hasConcept C147483822 @default.
• W2092860295 hasConcept C159654299 @default.
• W2092860295 hasConcept C172680121 @default.
• W2092860295 hasConcept C203014093 @default.
• W2092860295 hasConcept C26828662 @default.
• W2092860295 hasConcept C2778754761 @default.
• W2092860295 hasConcept C2779234561 @default.
• W2092860295 hasConcept C2779989375 @default.
• W2092860295 hasConcept C2780868878 @default.
• W2092860295 hasConcept C3018697912 @default.
• W2092860295 hasConcept C54355233 @default.
• W2092860295 hasConcept C71924100 @default.
• W2092860295 hasConcept C86803240 @default.
• W2092860295 hasConcept C8891405 @default.
• W2092860295 hasConcept C89560881 @default.
• W2092860295 hasConceptScore W2092860295C147483822 @default.
• W2092860295 hasConceptScore W2092860295C159654299 @default.

• next