FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092861683> ?p ?o ?g. }

• W2092861683 endingPage "446" @default.
• W2092861683 startingPage "441" @default.
• W2092861683 abstract "Background and objectives The aim of the study was to replace the 1st World Health Organization International Standard for parvovirus B19 DNA for nucleic acid amplification technique (NAT)-based assays (code 99/800). Two lyophilized preparations (coded 99/800 and 99/802) had been evaluated in the original collaborative study. The present study re-evaluates these two preparations in terms of potency, stability and encapsidation of virus DNA. Materials and methods The 1st International Standard (99/800) and 99/802 were re-coded as Samples 1 and 2, respectively. The samples were distributed to six laboratories and assayed on four separate occasions. Accelerated thermal degradation samples of the two preparations were examined after storage at 20°C for 7 years. Nuclease treatment was used to investigate the encapsidation of virus DNA. Results Data were returned from a total of six different quantitative NAT-based assays. The results of the present study confirm those of the original, with no significant differences found in estimated international units (IU)/ml for the 1st International Standard (Sample 1 in this study) and the proposed replacement preparation, Sample 2 (99/802). Accelerated thermal degradation studies demonstrate that both samples are very stable, with no loss of potency after storage at 20°C for 7 years. Both lyophilized preparations contained the majority of B19V DNA encapsidated in virions. Conclusions On the basis of the data presented in this collaborative study, Sample 2 (code number 99/802) was established as the 2nd International Standard for parvovirus B19 DNA for NAT-based assays with a potency of 106 IU/ml (500 000 IU/vial)." @default.
• W2092861683 created "2016-06-24" @default.
• W2092861683 creator A5003949764 @default.
• W2092861683 creator A5017393643 @default.
• W2092861683 creator A5038647047 @default.
• W2092861683 creator A5041315222 @default.
• W2092861683 creator A5041454171 @default.
• W2092861683 creator A5041801725 @default.
• W2092861683 creator A5077841485 @default.
• W2092861683 date "2010-04-01" @default.
• W2092861683 modified "2023-09-27" @default.
• W2092861683 title "Collaborative study to establish a replacement World Health Organization International Standard for parvovirus B19 DNA nucleic acid amplification technology (NAT)-based assays" @default.
• W2092861683 cites W1865473837 @default.
• W2092861683 cites W1968643368 @default.
• W2092861683 cites W1969615035 @default.
• W2092861683 cites W1972113102 @default.
• W2092861683 cites W1980841244 @default.
• W2092861683 cites W1987059443 @default.
• W2092861683 cites W1999144882 @default.
• W2092861683 cites W1999402293 @default.
• W2092861683 cites W2000236737 @default.
• W2092861683 cites W2004636633 @default.
• W2092861683 cites W2009543146 @default.
• W2092861683 cites W2013638726 @default.
• W2092861683 cites W2028693568 @default.
• W2092861683 cites W2090099466 @default.
• W2092861683 cites W2136676455 @default.
• W2092861683 cites W2150937648 @default.
• W2092861683 cites W2151205499 @default.
• W2092861683 doi "https://doi.org/10.1111/j.1423-0410.2009.01288.x" @default.
• W2092861683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20003130" @default.
• W2092861683 hasPublicationYear "2010" @default.
• W2092861683 type Work @default.
• W2092861683 sameAs 2092861683 @default.
• W2092861683 citedByCount "12" @default.
• W2092861683 countsByYear W20928616832012 @default.
• W2092861683 countsByYear W20928616832013 @default.
• W2092861683 countsByYear W20928616832015 @default.
• W2092861683 countsByYear W20928616832016 @default.
• W2092861683 countsByYear W20928616832018 @default.
• W2092861683 countsByYear W20928616832019 @default.
• W2092861683 crossrefType "journal-article" @default.
• W2092861683 hasAuthorship W2092861683A5003949764 @default.
• W2092861683 hasAuthorship W2092861683A5017393643 @default.
• W2092861683 hasAuthorship W2092861683A5038647047 @default.
• W2092861683 hasAuthorship W2092861683A5041315222 @default.
• W2092861683 hasAuthorship W2092861683A5041454171 @default.
• W2092861683 hasAuthorship W2092861683A5041801725 @default.
• W2092861683 hasAuthorship W2092861683A5077841485 @default.
• W2092861683 hasConcept C159047783 @default.
• W2092861683 hasConcept C182516595 @default.
• W2092861683 hasConcept C185592680 @default.
• W2092861683 hasConcept C24107716 @default.
• W2092861683 hasConcept C2522874641 @default.
• W2092861683 hasConcept C2779630601 @default.
• W2092861683 hasConcept C31258907 @default.
• W2092861683 hasConcept C41008148 @default.
• W2092861683 hasConcept C552990157 @default.
• W2092861683 hasConcept C55493867 @default.
• W2092861683 hasConcept C71924100 @default.
• W2092861683 hasConceptScore W2092861683C159047783 @default.
• W2092861683 hasConceptScore W2092861683C182516595 @default.
• W2092861683 hasConceptScore W2092861683C185592680 @default.
• W2092861683 hasConceptScore W2092861683C24107716 @default.
• W2092861683 hasConceptScore W2092861683C2522874641 @default.
• W2092861683 hasConceptScore W2092861683C2779630601 @default.
• W2092861683 hasConceptScore W2092861683C31258907 @default.
• W2092861683 hasConceptScore W2092861683C41008148 @default.
• W2092861683 hasConceptScore W2092861683C552990157 @default.
• W2092861683 hasConceptScore W2092861683C55493867 @default.
• W2092861683 hasConceptScore W2092861683C71924100 @default.
• W2092861683 hasIssue "3p2" @default.
• W2092861683 hasLocation W20928616831 @default.
• W2092861683 hasLocation W20928616832 @default.
• W2092861683 hasOpenAccess W2092861683 @default.
• W2092861683 hasPrimaryLocation W20928616831 @default.
• W2092861683 hasRelatedWork W1979807665 @default.
• W2092861683 hasRelatedWork W1992198206 @default.
• W2092861683 hasRelatedWork W2088521468 @default.
• W2092861683 hasRelatedWork W2125817292 @default.
• W2092861683 hasRelatedWork W2292930107 @default.
• W2092861683 hasRelatedWork W2324500592 @default.
• W2092861683 hasRelatedWork W2342106670 @default.
• W2092861683 hasRelatedWork W2372432390 @default.
• W2092861683 hasRelatedWork W30612849 @default.
• W2092861683 hasRelatedWork W4213193147 @default.
• W2092861683 hasVolume "98" @default.
• W2092861683 isParatext "false" @default.
• W2092861683 isRetracted "false" @default.
• W2092861683 magId "2092861683" @default.
• W2092861683 workType "article" @default.