FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092862007> ?p ?o ?g. }

• W2092862007 endingPage "266" @default.
• W2092862007 startingPage "257" @default.
• W2092862007 abstract "LMP2A is consistently detected in Hodgkin's lymphoma, nasopharyngeal carcinoma and has also been detected in Burkitt's lymphoma. Interestingly, LMP2A is detected in the absence of the transcriptional activator EBNA2, suggesting that an alternative mechanism is responsible for LMP2A expression. The intracellular domain of Notch (Notch-IC) and EBNA2 are functional homologs and recent microarray analysis indicates that LMP2A may constitutively activate the Notch pathway in vivo. Coupled with evidence that Notch-IC can bind to and activate the LMP2A promoter, we hypothesized that expression of LMP2A results in the constitutive activation of the Notch pathway to auto-regulate its promoter. Our data indicate that LMP2A constitutively activates the Notch pathway in B cells and epithelial cells. Expression of LMP2A alone is sufficient to activate its own expression and the amino-terminal signaling domain is required as LMP2B is unable to activate the LMP2A promoter. In addition, point mutations in tyrosines 31, 101 and 112 each results in a significant decrease in LMP2A promoter activation. Deletion of the RBP-Jkappa consensus sequences results in a significant decrease in promoter activity. The observation that LMP2A activates its own promoter suggests that LMP2A exploits the Notch pathway in order to control its own expression and may explain EBNA2-independent expression of LMP2A in EBV-associated malignancies." @default.
• W2092862007 created "2016-06-24" @default.
• W2092862007 creator A5009157428 @default.
• W2092862007 creator A5011262485 @default.
• W2092862007 date "2008-02-01" @default.
• W2092862007 modified "2023-10-15" @default.
• W2092862007 title "An auto-regulatory loop for EBV LMP2A involves activation of Notch" @default.
• W2092862007 cites W1531345299 @default.
• W2092862007 cites W1600425139 @default.
• W2092862007 cites W1657159422 @default.
• W2092862007 cites W1660631781 @default.
• W2092862007 cites W1699631922 @default.
• W2092862007 cites W1753716921 @default.
• W2092862007 cites W1850316869 @default.
• W2092862007 cites W1910448222 @default.
• W2092862007 cites W1918536345 @default.
• W2092862007 cites W1941789860 @default.
• W2092862007 cites W1968710367 @default.
• W2092862007 cites W1968916768 @default.
• W2092862007 cites W1970269101 @default.
• W2092862007 cites W1978047615 @default.
• W2092862007 cites W1979401674 @default.
• W2092862007 cites W1981298981 @default.
• W2092862007 cites W1982859277 @default.
• W2092862007 cites W1988115626 @default.
• W2092862007 cites W1996168666 @default.
• W2092862007 cites W2007400424 @default.
• W2092862007 cites W2012913175 @default.
• W2092862007 cites W2015010828 @default.
• W2092862007 cites W2015693481 @default.
• W2092862007 cites W2016141331 @default.
• W2092862007 cites W2018338402 @default.
• W2092862007 cites W2037500777 @default.
• W2092862007 cites W2042610645 @default.
• W2092862007 cites W2043216348 @default.
• W2092862007 cites W2062043644 @default.
• W2092862007 cites W2066784330 @default.
• W2092862007 cites W2068284531 @default.
• W2092862007 cites W2073618113 @default.
• W2092862007 cites W2074479811 @default.
• W2092862007 cites W2082920598 @default.
• W2092862007 cites W2089038328 @default.
• W2092862007 cites W2096351015 @default.
• W2092862007 cites W2096403595 @default.
• W2092862007 cites W2097615937 @default.
• W2092862007 cites W2099068827 @default.
• W2092862007 cites W2108246278 @default.
• W2092862007 cites W2108581914 @default.
• W2092862007 cites W2119600157 @default.
• W2092862007 cites W2120355178 @default.
• W2092862007 cites W2130081467 @default.
• W2092862007 cites W2135290063 @default.
• W2092862007 cites W2136658945 @default.
• W2092862007 cites W2140538576 @default.
• W2092862007 cites W2142338219 @default.
• W2092862007 cites W2146007990 @default.
• W2092862007 cites W2146288152 @default.
• W2092862007 cites W2150357985 @default.
• W2092862007 cites W2151909421 @default.
• W2092862007 cites W2154597953 @default.
• W2092862007 cites W2156374986 @default.
• W2092862007 cites W2159117635 @default.
• W2092862007 cites W2159147754 @default.
• W2092862007 cites W2159327683 @default.
• W2092862007 cites W2164492333 @default.
• W2092862007 cites W2166896992 @default.
• W2092862007 cites W2167183696 @default.
• W2092862007 cites W2168332137 @default.
• W2092862007 cites W2275536956 @default.
• W2092862007 cites W2316037107 @default.
• W2092862007 doi "https://doi.org/10.1016/j.virol.2007.10.009" @default.
• W2092862007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2288488" @default.
• W2092862007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17980397" @default.
• W2092862007 hasPublicationYear "2008" @default.
• W2092862007 type Work @default.
• W2092862007 sameAs 2092862007 @default.
• W2092862007 citedByCount "31" @default.
• W2092862007 countsByYear W20928620072012 @default.
• W2092862007 countsByYear W20928620072014 @default.
• W2092862007 countsByYear W20928620072015 @default.
• W2092862007 countsByYear W20928620072016 @default.
• W2092862007 countsByYear W20928620072018 @default.
• W2092862007 countsByYear W20928620072019 @default.
• W2092862007 countsByYear W20928620072020 @default.
• W2092862007 countsByYear W20928620072021 @default.
• W2092862007 countsByYear W20928620072023 @default.
• W2092862007 crossrefType "journal-article" @default.
• W2092862007 hasAuthorship W2092862007A5009157428 @default.
• W2092862007 hasAuthorship W2092862007A5011262485 @default.
• W2092862007 hasBestOaLocation W20928620071 @default.
• W2092862007 hasConcept C104317684 @default.
• W2092862007 hasConcept C150194340 @default.
• W2092862007 hasConcept C153911025 @default.
• W2092862007 hasConcept C161879069 @default.
• W2092862007 hasConcept C165864922 @default.
• W2092862007 hasConcept C202769670 @default.
• W2092862007 hasConcept C27153228 @default.
• W2092862007 hasConcept C502942594 @default.

• next