FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092867585> ?p ?o ?g. }

• W2092867585 endingPage "621" @default.
• W2092867585 startingPage "615" @default.
• W2092867585 abstract "Previous crystallographic analyses have demonstrated that proteolytic cleavage of the serpins can result in a dramatic transformation of their tertiary structure. Some 16 residues on the amino terminal side of the cleavage site are inserted into a large β-sheet to become a central strand, separating the two cleaved residues by about 70 Å. We have determined, in outline, the nature of the conformational change responsible for this transformation. After cleavage, a fragment of the protein, consisting of an α-helix and three strands of β-sheet, moves away from the rest of the structure to make the space for the new strand. This movement involves a new type of structural change: sheet residues in the small fragment slide along grooves in an α-helix that belongs to the rest of the protein. The general conservation of residues in the regions between the small fragment and the rest of the protein imply that the same mechanism will be found in all serpins that undergo this tertiary structure transformation." @default.
• W2092867585 created "2016-06-24" @default.
• W2092867585 creator A5000803234 @default.
• W2092867585 creator A5091546669 @default.
• W2092867585 date "1991-09-01" @default.
• W2092867585 modified "2023-10-11" @default.
• W2092867585 title "Serpin tertiary structure transformation" @default.
• W2092867585 cites W1508885706 @default.
• W2092867585 cites W1522561094 @default.
• W2092867585 cites W1562752364 @default.
• W2092867585 cites W1566966348 @default.
• W2092867585 cites W1589897785 @default.
• W2092867585 cites W174279387 @default.
• W2092867585 cites W1966041739 @default.
• W2092867585 cites W1979117430 @default.
• W2092867585 cites W1997950632 @default.
• W2092867585 cites W2001570522 @default.
• W2092867585 cites W2004360551 @default.
• W2092867585 cites W2006876120 @default.
• W2092867585 cites W2008405604 @default.
• W2092867585 cites W2040295790 @default.
• W2092867585 cites W2062351773 @default.
• W2092867585 cites W2066192733 @default.
• W2092867585 cites W2084465075 @default.
• W2092867585 cites W2177861138 @default.
• W2092867585 cites W2235400136 @default.
• W2092867585 cites W2252063895 @default.
• W2092867585 cites W330357786 @default.
• W2092867585 cites W4230158786 @default.
• W2092867585 doi "https://doi.org/10.1016/0022-2836(91)80076-7" @default.
• W2092867585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1920436" @default.
• W2092867585 hasPublicationYear "1991" @default.
• W2092867585 type Work @default.
• W2092867585 sameAs 2092867585 @default.
• W2092867585 citedByCount "148" @default.
• W2092867585 countsByYear W20928675852012 @default.
• W2092867585 countsByYear W20928675852013 @default.
• W2092867585 countsByYear W20928675852014 @default.
• W2092867585 countsByYear W20928675852016 @default.
• W2092867585 countsByYear W20928675852017 @default.
• W2092867585 countsByYear W20928675852018 @default.
• W2092867585 countsByYear W20928675852019 @default.
• W2092867585 countsByYear W20928675852021 @default.
• W2092867585 countsByYear W20928675852022 @default.
• W2092867585 countsByYear W20928675852023 @default.
• W2092867585 crossrefType "journal-article" @default.
• W2092867585 hasAuthorship W2092867585A5000803234 @default.
• W2092867585 hasAuthorship W2092867585A5091546669 @default.
• W2092867585 hasConcept C104317684 @default.
• W2092867585 hasConcept C12554922 @default.
• W2092867585 hasConcept C151730666 @default.
• W2092867585 hasConcept C159547669 @default.
• W2092867585 hasConcept C175156509 @default.
• W2092867585 hasConcept C185592680 @default.
• W2092867585 hasConcept C18903297 @default.
• W2092867585 hasConcept C204241405 @default.
• W2092867585 hasConcept C2777339483 @default.
• W2092867585 hasConcept C2778530040 @default.
• W2092867585 hasConcept C2778965386 @default.
• W2092867585 hasConcept C2779965526 @default.
• W2092867585 hasConcept C43369102 @default.
• W2092867585 hasConcept C47701112 @default.
• W2092867585 hasConcept C55493867 @default.
• W2092867585 hasConcept C71240020 @default.
• W2092867585 hasConcept C75599170 @default.
• W2092867585 hasConcept C8010536 @default.
• W2092867585 hasConcept C86803240 @default.
• W2092867585 hasConceptScore W2092867585C104317684 @default.
• W2092867585 hasConceptScore W2092867585C12554922 @default.
• W2092867585 hasConceptScore W2092867585C151730666 @default.
• W2092867585 hasConceptScore W2092867585C159547669 @default.
• W2092867585 hasConceptScore W2092867585C175156509 @default.
• W2092867585 hasConceptScore W2092867585C185592680 @default.
• W2092867585 hasConceptScore W2092867585C18903297 @default.
• W2092867585 hasConceptScore W2092867585C204241405 @default.
• W2092867585 hasConceptScore W2092867585C2777339483 @default.
• W2092867585 hasConceptScore W2092867585C2778530040 @default.
• W2092867585 hasConceptScore W2092867585C2778965386 @default.
• W2092867585 hasConceptScore W2092867585C2779965526 @default.
• W2092867585 hasConceptScore W2092867585C43369102 @default.
• W2092867585 hasConceptScore W2092867585C47701112 @default.
• W2092867585 hasConceptScore W2092867585C55493867 @default.
• W2092867585 hasConceptScore W2092867585C71240020 @default.
• W2092867585 hasConceptScore W2092867585C75599170 @default.
• W2092867585 hasConceptScore W2092867585C8010536 @default.
• W2092867585 hasConceptScore W2092867585C86803240 @default.
• W2092867585 hasIssue "2" @default.
• W2092867585 hasLocation W20928675851 @default.
• W2092867585 hasLocation W20928675852 @default.
• W2092867585 hasOpenAccess W2092867585 @default.
• W2092867585 hasPrimaryLocation W20928675851 @default.
• W2092867585 hasRelatedWork W141127043 @default.
• W2092867585 hasRelatedWork W1566966348 @default.
• W2092867585 hasRelatedWork W1964184975 @default.
• W2092867585 hasRelatedWork W2005557554 @default.
• W2092867585 hasRelatedWork W2056718503 @default.
• W2092867585 hasRelatedWork W2062744088 @default.
• W2092867585 hasRelatedWork W2110573698 @default.

• next